Thorpe reaction

The Thorpe reaction is a chemical reaction described as a self-condensation of aliphatic nitriles catalyzed by base to form enamines.[1][2][3] The reaction was discovered by Jocelyn Field Thorpe.

Thorpe–Ziegler reaction

The Thorpe–Ziegler reaction (named after Jocelyn Field Thorpe and Karl Ziegler), or Ziegler method, is the intramolecular modification with a dinitrile as a reactant and a cyclic ketone as the final reaction product after acidic hydrolysis. The reaction is conceptually related to the Dieckmann condensation.[3]


References

  1. ↑ Baron, Harold; Remfry, Frederick George Percy; Thorpe, Jocelyn Field (1904). "CLXXV.—The formation and reactions of imino-compounds. Part I. Condensation of ethyl cyanoacetate with its sodium derivative". J. Chem. Soc., Trans. 85 (0): 1726–1761. ISSN 0368-1645. doi:10.1039/CT9048501726.
  2. ↑ Ziegler, K.; Eberle, H.; Ohlinger, H. (1933). "Über vielgliedrige Ringsysteme. I. Die präparativ ergiebige Synthese der Polymethylenketone mit mehr als 6 Ringgliedern". Justus Liebig's Annalen der Chemie (in German). 504 (1): 94–130. ISSN 0075-4617. doi:10.1002/jlac.19335040109.
  3. 1 2 Schaefer, John P.; Bloomfield, Jordan J. (2011). "The Dieckmann Condensation (Including the Thorpe-Ziegler Condensation)": 1–203. doi:10.1002/0471264180.or015.01.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.