ZNF202

ZNF202
Identifiers
AliasesZNF202, ZKSCAN10, ZSCAN42, zinc finger protein 202
External IDsMGI: 1933401 HomoloGene: 68317 GeneCards: ZNF202
Gene location (Human)
Chr.Chromosome 11 (human)[1]
BandNo data availableStart123,724,177 bp[1]
End123,741,675 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

7753

80902

Ensembl

ENSG00000166261

ENSMUSG00000025602

UniProt

O95125

n/a

RefSeq (mRNA)

NM_001301779
NM_001301780
NM_001301819
NM_003455

NM_030713

RefSeq (protein)

NP_001288708
NP_001288709
NP_001288748
NP_003446

n/a

Location (UCSC)Chr 11: 123.72 – 123.74 MbChr 11: 40.19 – 40.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger protein 202 is a transcription factor first associated with breast cancer. It is a protein that, in humans, is encoded by the ZNF202 gene.[5][6]

Clinical significance

Variants of this protein have been discovered to be strongly associated with coronary heart disease and atherosclerosis.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000166261 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025602 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Monaco C, Helmer Citterich M, Caprini E, Vorechovsky I, Russo G, Croce CM, Barbanti-Brodano G, Negrini M (Sep 1998). "Molecular cloning and characterization of ZNF202: a new gene at 11q23.3 encoding testis-specific zinc finger proteins". Genomics. 52 (3): 358–62. PMID 9790754. doi:10.1006/geno.1998.5419.
  6. ↑ "Entrez Gene: ZNF202 zinc finger protein 202".

Further reading

  • Iuchi, Shiro; Kuldell, Natalie (2005). Zinc finger proteins: from atomic contact to cellular function. Molecular biology intelligence unit. シュプリンガー・ジャパン株式会社. p. 161. ISBN 0-306-48229-0. 
  • Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ (Nov 1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". International Journal of Cancer. Journal International Du Cancer. 83 (4): 456–64. PMID 10508479. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. 
  • Schumacher C, Wang H, Honer C, Ding W, Koehn J, Lawrence Q, Coulis CM, Wang LL, Ballinger D, Bowen BR, Wagner S (Jun 2000). "The SCAN domain mediates selective oligomerization". The Journal of Biological Chemistry. 275 (22): 17173–9. PMID 10747874. doi:10.1074/jbc.M000119200. 
  • Wagner S, Hess MA, Ormonde-Hanson P, Malandro J, Hu H, Chen M, Kehrer R, Frodsham M, Schumacher C, Beluch M, Honer C, Skolnick M, Ballinger D, Bowen BR (May 2000). "A broad role for the zinc finger protein ZNF202 in human lipid metabolism". The Journal of Biological Chemistry. 275 (21): 15685–90. PMID 10748193. doi:10.1074/jbc.M910152199. 
  • Porsch-Ozcurumez M, Langmann T, Heimerl S, Borsukova H, Kaminski WE, Drobnik W, Honer C, Schumacher C, Schmitz G (Apr 2001). "The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux". The Journal of Biological Chemistry. 276 (15): 12427–33. PMID 11279031. doi:10.1074/jbc.M100218200. 
  • Babb R, Bowen BR (Mar 2003). "SDP1 is a peroxisome-proliferator-activated receptor gamma 2 co-activator that binds through its SCAN domain". The Biochemical Journal. 370 (Pt 2): 719–27. PMC 1223195 Freely accessible. PMID 12444922. doi:10.1042/BJ20021378. 
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209. 
  • Stene MC, Frikke-Schmidt R, Nordestgaard BG, Steffensen R, Schnohr P, Tybjaerg-Hansen A (Sep 2006). "Zinc Finger Protein 202: a new candidate gene for ischemic heart disease: The Copenhagen City Heart Study". Atherosclerosis. 188 (1): 43–50. PMID 16289551. doi:10.1016/j.atherosclerosis.2005.10.014. 
  • Stene MC, Frikke-Schmidt R, Nordestgaard BG, Tybjaerg-Hansen A (May 2006). "Zinc Finger Protein 202, genetic variation, and HDL cholesterol in the general population". Journal of Lipid Research. 47 (5): 944–52. PMID 16467280. doi:10.1194/jlr.M500521-JLR200. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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