ZIP9

SLC39A9
Identifiers
AliasesSLC39A9, ZIP-9, ZIP9, solute carrier family 39 member 9
External IDsMGI: 1914820 HomoloGene: 6935 GeneCards: SLC39A9
Gene location (Human)
Chr.Chromosome 14 (human)[1]
BandNo data availableStart69,398,015 bp[1]
End69,462,388 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

55334

328133

Ensembl

ENSG00000029364

ENSMUSG00000048833

UniProt

Q9NUM3

Q8BFU1

RefSeq (mRNA)

NM_026244

RefSeq (protein)

NP_080520

Location (UCSC)Chr 14: 69.4 – 69.46 MbChr 14: 80.64 – 80.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zrt- and Irt-like protein 9 (ZIP9), also known as solute carrier family 39 member 9 (SLC39A9), is a protein which is encoded by the SLC39A9 gene.[5] It is a membrane androgen receptor (mAR) coupled to G proteins and a zinc transporter protein.[5][6][7] Through activation of ZIP9, testosterone has been found to increase intracellular zinc levels in breast cancer, prostate cancer, and ovarian follicle cells and to induce apoptosis in these cells, an action which may be mediated partially or fully by increased zinc concentrations.[5][8]

In contrast to testosterone, which has high affinity for ZIP9 with a Kd of 14 nM, the other endogenous androgens dihydrotestosterone (DHT) and androstenedione show low affinity for the receptor with less than 1% of that of testosterone, although DHT is still effective in activating the receptor at sufficiently high concentrations.[5] Moreover, the synthetic androgens mibolerone and metribolone (R-1881), the endogenous androgen 11-ketotestoterone, and the other steroid hormones estradiol and cortisol are all ineffective competitors for the receptor.[5] As such, mibolerone and metribolone could potentially be employed to differentiate between androgen receptor- and ZIP9-mediated responses of testosterone.[5]

See also

References



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