ZHX1
Zinc fingers and homeoboxes protein 1 is a protein that in humans is encoded by the ZHX1 gene.[5][6]
The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 1 of this gene family. In addition to forming homodimers, this protein heterodimerizes with members 2 and 3 of the zinc fingers and homeoboxes family. Alternative splicing results in multiple transcript variants encoding the same protein.[6]
Interactions
ZHX1 has been shown to interact with NFYA.[5][7]
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000165156 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022361 - Ensembl, May 2017
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- 1 2 Yamada K, Printz RL, Osawa H, Granner DK (Sep 1999). "Human ZHX1: cloning, chromosomal location, and interaction with transcription factor NF-Y". Biochem Biophys Res Commun. 261 (3): 614–21. PMID 10441475. doi:10.1006/bbrc.1999.1087.
- 1 2 "Entrez Gene: ZHX1 zinc fingers and homeoboxes 1".
- ↑ Yamada, K; Osawa H; Granner D K (Oct 1999). "Identification of proteins that interact with NF-YA". FEBS Lett. NETHERLANDS. 460 (1): 41–5. ISSN 0014-5793. PMID 10571058. doi:10.1016/S0014-5793(99)01311-3.
Further reading
- Yamada K, Osawa H, Granner DK (1999). "Identification of proteins that interact with NF-YA.". FEBS Lett. 460 (1): 41–5. PMID 10571058. doi:10.1016/S0014-5793(99)01311-3.
- Hirano S, Yamada K, Kawata H, et al. (2002). "Rat zinc-fingers and homeoboxes 1 (ZHX1), a nuclear factor-YA-interacting nuclear protein, forms a homodimer.". Gene. 290 (1–2): 107–14. PMID 12062805. doi:10.1016/S0378-1119(02)00553-X.
- Yamada K, Kawata H, Matsuura K, et al. (2002). "Functional analysis and the molecular dissection of zinc-fingers and homeoboxes 1 (ZHX1).". Biochem. Biophys. Res. Commun. 297 (2): 368–74. PMID 12237128. doi:10.1016/S0006-291X(02)02203-9.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241
. PMID 12477932. doi:10.1073/pnas.242603899. - Yamada K, Kawata H, Shou Z, et al. (2003). "Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3.". Biochem. J. 373 (Pt 1): 167–78. PMC 1223464 . PMID 12659632. doi:10.1042/BJ20021866.
- Kawata H, Yamada K, Shou Z, et al. (2003). "Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor.". Biochem. J. 373 (Pt 3): 747–57. PMC 1223552 . PMID 12741956. doi:10.1042/BJ20030171.
- Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.". Genomics. 83 (1): 153–67. PMID 14667819. doi:10.1016/S0888-7543(03)00235-0.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
- Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. PMID 15146197. doi:10.1038/nbt971.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. PMC 514446 . PMID 15302935. doi:10.1073/pnas.0404720101.
- Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.". Mol. Cell. 15 (6): 853–65. PMID 15383276. doi:10.1016/j.molcel.2004.09.016.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell. 122 (6): 957–68. PMID 16169070. doi:10.1016/j.cell.2005.08.029.
- Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell. 125 (4): 801–14. PMID 16713569. doi:10.1016/j.cell.2006.03.032.
- Liu G, Clement LC, Kanwar YS, et al. (2007). "ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome.". J. Biol. Chem. 281 (51): 39681–92. PMID 17056598. doi:10.1074/jbc.M606664200.
- Kim SH, Park J, Choi MC, et al. (2007). "Zinc-fingers and homeoboxes 1 (ZHX1) binds DNA methyltransferase (DNMT) 3B to enhance DNMT3B-mediated transcriptional repression.". Biochem. Biophys. Res. Commun. 355 (2): 318–23. PMID 17303076. doi:10.1016/j.bbrc.2007.01.187.
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