ZFYVE27

ZFYVE27
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesZFYVE27, PROTRUDIN, SPG33, zinc finger FYVE-type containing 27
External IDsMGI: 1919602 HomoloGene: 16939 GeneCards: ZFYVE27
Gene location (Human)
Chr.Chromosome 10 (human)[1]
BandNo data availableStart97,737,121 bp[1]
End97,760,907 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

118813

319740

Ensembl

ENSG00000155256

ENSMUSG00000018820

UniProt

Q5T4F4

Q3TXX3

RefSeq (mRNA)

NM_001164531
NM_177319

RefSeq (protein)

NP_001158003
NP_796293

Location (UCSC)Chr 10: 97.74 – 97.76 MbChr 10: 42.16 – 42.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger, FYVE domain containing 27 is a protein that in humans is encoded by the ZFYVE27 gene.[5]

Function

This gene encodes a protein with several Transmembrane domains, a Rab11-binding domain and a lipid-binding FYVE finger domain. The encoded protein appears to promote Neuriteformation. A mutation in this gene has been reported to be associated with Hereditary spastic paraplegia, however the Pathogenicity of the mutation, which may simply represent a Polymorphism (biology), is unclear. [provided by RefSeq, Mar 2010].

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000155256 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018820 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: Zinc finger, FYVE domain containing 27".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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