Y-27632

Y-27632
Names

IUPAC name (1R,4r)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide
Identifiers
CAS Number	146986-50-7^Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:75393^N
ChemSpider	20016532^Y
DrugBank	DB08756^Y
IUPHAR/BPS	5290
PubChem CID	448042
InChI InChI=1S/C14H21N3O/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13/h6-12H,2-5,15H2,1H3,(H,16,17,18)/t10-,11-,12-/m1/s1^Y Key: IYOZTVGMEWJPKR-IJLUTSLNSA-N^Y InChI=1/C14H21N3O/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13/h6-12H,2-5,15H2,1H3,(H,16,17,18)/t10-,11-,12-/m1/s1 Key: IYOZTVGMEWJPKR-IJLUTSLNBP
SMILES O=C([C@H]1CC[C@@]([C@H](N)C)([H])CC1)NC2=CC=NC=C2
Properties
Chemical formula	C₁₄H₂₁N₃O
Molar mass	247.34 g·mol⁻¹
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is ^YN ?)
Infobox references

Y-27632 is a biochemical tool used in the study of the rho-associated protein kinase (ROCK) signaling pathways.^[1] Y-27632 selectively inhibits p160ROCK.^[2]

It has been studied for its effects on corneal endothelial cells(CECs) ^[3] and cardiac stem cells (CSCs).^[4]

References

↑ Uehata, Masayoshi (1999). "Y-27632. Selective probe of ROCK/Rho-kinase". Jikken Igaku. 17 (7): 850–855.
↑ Uehata, M; Ishizaki, T; Satoh, H; Ono, T; Kawahara, T; Morishita, T; Tamakawa, H; Yamagami, K; et al. (1997). "Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension". Nature. 389 (6654): 990–4. PMID 9353125. doi:10.1038/40187.
↑ Peh, Gary S. L.; Adnan, Khadijah; George, Benjamin L.; Ang, Heng-Pei; Seah, Xin-Yi; Tan, Donald T.; Mehta, Jodhbir S. (2015-03-16). "The effects of Rho-associated kinase inhibitor Y-27632 on primary human corneal endothelial cells propagated using a dual media approach". Scientific Reports. 5. ISSN 2045-2322. PMC 4387913 . PMID 25823914. doi:10.1038/srep09167.
↑ Kan, Lijuan; Smith, Aubrie; Chen, Miao; Ledford, Benjamin T.; Fan, Huimin; Liu, Zhongmin; He, Jia-Qiang (2015-12-08). "Rho-Associated Kinase Inhibitor (Y-27632) Attenuates Doxorubicin-Induced Apoptosis of Human Cardiac Stem Cells". PLOS ONE. 10 (12): e0144513. ISSN 1932-6203. PMC 4672899 . PMID 26645568. doi:10.1371/journal.pone.0144513.

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