Xiaoliang Sunney Xie

Xiaoliang Sunney Xie

Born	(1962-06-24) June 24, 1962 Beijing, China
Fields	Biophysical Chemistry, Optical Imaging, Genomics
Institutions	Harvard University Peking University
Education	BSc in Chemistry from Peking University PhD in Physical Chemistry from UC San Diego
Known for	Single Molecule Enzymology, Coherent Raman Imaging, Single Cell Genomics
Notable awards	Albany Prize in Medicine and Biomedical Research 2015, Peter Debye Award in Physical Chemistry 2015, Ellis R. Lippincott Award 2013, Biophysical Society Founders Award 2012

Professor Xiaoliang Sunney Xie (Chinese: 谢晓亮; born 1962 in Beijing, China) is considered a founding father of single-molecule biophysical chemistry and single-molecule enzymology.^[1] He received his B.Sc. in Chemistry from Peking University in 1984, and his Ph.D. in Physical Chemistry in 1990 from University of California at San Diego. After a brief postdoctoral appointment at University of Chicago, he joined Pacific Northwest National Laboratory, where he rose from Senior Research Scientist to Chief Scientist. In 1998, he became the first tenured professor at Harvard University among Chinese Scholars who came to the United States since the Reform in China.

As a pioneer of single-molecule biophysical chemistry, coherent Raman scattering microscopy, and single-cell genomics, he made major contributions to the emergence of these fields. Furthermore, he has made significant advances on medical applications of label-free optical imaging and single-cell genomics. In particular, his inventions in single-cell genomics have been used in in vitro fertilization to benefit hundreds of couples in China by avoiding the transmission of monogenic diseases to their newborns.

Currently, Xie is the Mallinckrodt Professor of Chemistry and Chemical Biology at Harvard University. He is also the Director of Biodynamics Optical Imaging Center (BIOPIC) since 2010, and the Director of Beijing Advanced Innovation Center for Genomics (ICG) since 2016, both at Peking University.

As of April 2017, Xie has published over 210 papers. More than forty of his students and post-doctorates have become professors at major universities around the world, and two are co-founders of start-up companies.

Professor Xie’s current research interests include the following scientific, technological, and medical areas:

Scientific: Single-molecule enzymology, Single-molecule biophysical chemistry, Gene expression and regulation, Epigenetics, Mechanism of cell differentiation and reprogramming, Chromosome structure and dynamics, and Genomic instability;
Technological: Single-molecule imaging, Single-cell genomics, Coherent Raman scattering microscopy, DNA sequencing;
Medical: Preimplantation genetic testing in in vitro fertilization, and Early cancer diagnosis

Honors and awards

2016: Member of the National Academy of Medicine^[2]
2015: Albany Medical Center Prize^[3]
2015: Peter Debye Award in Physical Chemistry, American Chemical Society^[4]
2014: Fellow of the Optical Society of America
2013: NIH Director's Pioneer Award^[5]
2013: Ellis R. Lippincott Award, Optical Society of America and Society for Applied Spectroscopy^[6]
2012: Harrison Howe Award, Rochester Section of the American Chemical Society
2012: Fellow of the American Academy of Microbiology
2012: Biophysical Society Founders Award
2011: Member of the National Academy of Sciences
2009: Ernest Orlando Lawrence Award
2008: Fellow of the American Physical Society
2008: Berthold Leibinger Zukunftspreis for Applied Laser Technology^[7]
2008: Fellow of the American Academy of Arts and Sciences
2007: Willis E. Lamb Award for Laser Sciences and Quantum Optics^[8]
2006: Fellow of Biophysical Society
2006: Fellow of the American Association for the Advancement of Science
2004: NIH Director's Pioneer Award^[9]
2003: Raymond and Beverly Sackler Prize in the Physical Sciences
1996: Coblentz Award

Selected Literature

Single-Cell Genomics

Chen, Chongyi; Xing, Dong; Tan, Longzhi; Li, Heng; Zhou, Guangyu; Huang, Lei; Xie, X. Sunney. "Single-cell whole-genome analyses by Linear Amplification via Transposon Insertion (LIANTI)," Science 356, 189-194. (2017)
Yan, Liying; Huang, Lei; Xu, Liya; Huang, Jin; Ma, Fei; Zhu, Xiaohui; Tang, Yaqiong; Liu, Mingshan; Lian, Ying; Liu, Ping; Li, Rong; Lu, Sijia; Tang, Fuchou; Qiao, Jie; Xie, X Sunney. "Live births after simultaneous avoidance of monogenic diseases and chromosome abnormality by next-generation sequencing with linkage analyses," Proc Natl Acad Sci USA, 112(52), 15964-15969 (2015).
Hou, Yu; Fan, Wei; Yan, Liying; Li, Rong; Lian, Ying; Huang, Jin; Li, Jinsen; Xu, Liya; Tang, Fuchou; Xie, X. Sunney; Qiao, Jie. "Genome Analyses of Single Human Oocytes," Cell 155, 1492-1506 (2013)
Zong, Chenghang; Lu, Sijia; Chapman, Alec R.; Xie, X. Sunney. "Genome-Wide Detection of Single-Nucleotide and Copy-Number Variations of a Single Human Cell" Science 338, 1622-1626 (2012).

Gene Expression and Regulation

Chong, Shasha; Chen, Chongyi; Ge, Hao; Xie X. Sunney. “Mechanism of Transcriptional Bursting in Bacteria,” Cell 158, 314-326 (2014).
Taniguchi, Yuichi; Choi, Paul J.; Li, Gene-Wei; Chen, Huiyi; Babu, Mohan; Hearn, Jeremy; Emili, Andrew; Xie, X. Sunney. "Quantifying E. coli Proteome and Transcriptome with Single-Molecule Sensitivity in Single Cells," Science 329: 533-538 (2010).
Choi, Paul J.; Cai, Long; Frieda, Kirsten; Xie, X. Sunney. "A Stochastic Single-Molecule Event Triggers Phenotype Switching of a Bacterial Cell," Science 322, 442-446 (2008).
Elf, Johan; Li, Gene-Wei; Xie, X. Sunney. "Probing Transcription Factor Dynamics at the Single-Molecule Level in a Living Cell," Science 316, 1191-1194 (2007).
Yu, Ji; Xiao, Jie; Ren, Xiaojia; Lao, Kaiqin; Xie, X. Sunney. "Probing Gene Expression in Live Cells, One Protein Molecule at a Time," Science 311, 1600-1603 (2006).
Cai, Long; Friedman, Nir; Xie, X. Sunney. "Stochastic Protein Expression in Individual Cells at the Single Molecule Level," Nature 440, 358-362 (2006).

Single Molecule Enzymology

Chong, Shasha; Chen, Chongyi; Ge, Hao; Xie X. Sunney. “Mechanism of Transcriptional Bursting in Bacteria,” Cell 158, 314-326 (2014).
Kim, Sangjin; Broströmer, Erik, Xing, Dong; Jin, Jianshi; Chong, Shasha; Ge, Hao, Wang, Siyuan; Gu, Chan; Yang, Lijiang; Gao, Yiqin; Su, Xiao-dong; Sun, Yujie; Xie, X. Sunney. “Probing Allostery Through DNA,” Science, 339: 816-819 (2013).
English, Brian P.; Min, Wei; van Oijen, Antoine M.; Lee, Kang Taek; Luo, Guobin; Sun, Hongye; Cherayil, Binny J.; Kou, S.C.; Xie, X. Sunney. "Ever-Fluctuating Single Enzyme Molecules: Michaelis-Menten Equation Revisited" Nat Chem Bio 2: 87-94 (2006).
Yang, Haw; Luo, Guobin; Karnchanaphanurach, Pallop; Louie, Tai-Man; Rech, Ivan; Cova, Sergio; Xun, Luying; Xie, X. Sunney. "Protein Conformational Dynamics Probed by Single-Molecule Electron Transfer," Science 302, 262-266 (2003).
Lu, H. Peter; Xun, Luying; Xie, X. Sunney. "Single-Molecule Enzymatic Dynamics," Science 282: 1877-1882 (1998).

Coherent Raman Imaging

Ji, Minbiao; Orringer, Daniel A.; Freudiger, Christian W.; Ramkissoon, Shakti; Liu, Xiaohui; Lau, Darryl; Golby, Alexandra J.; Norton, Isaiah; Hayashi, Marika; Agar, Nathalie Y. R.; Young, Geoffrey S.; Spino, Cathie; Santagata, Sandro; Camelo-Piragua, Sandra; Ligon, Keith L.; Sagher, Oren; Xie, X. Sunney. "Rapid, Label-Free Detection of Brain Tumors with Stimulated Raman Scattering Microscopy," Science Translational Medicine 5, 201ra119 (2013).
Wang, Meng C.; Min, Wei; Freudiger, Christian W.; Ruvkun, Gary; Xie, X. Sunney. "RNAi Screening for Fat Regulatory Genes with SRS Microscopy," Nat Methods 8, 135-138 (2011).
Saar, Brian G.; Freudiger, Christian W.; Reichman, Jay; Stanley, C. Michael; Holtom, Gary R.; Xie, X. Sunney. "Video-Rate Molecular Imaging in Vivo with Stimulated Raman Scattering," Science 330, 1368-1370 (2010).
Freudiger, Christian W.; Min, Wei; Saar, Brian G.; Lu, Sijia; Holtom, Gary R.; He, Chengwei; Tsai, Jason C.; Kang, Jing X.; Xie, X. Sunney. "Label-Free Biomedical Imaging with High sensitivity by Stimulated Raman Scattering Microscopy," Science 322, 1857-1860 (2008).
Evans, Conor L.; Potma, Eric O.; Puoris'haag, Mehron; Côté, Daniel; Lin, Charles P.; Xie, X. Sunney. "Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy" Proc Nat. Aca Sci 102, 16807-16812 (2005
Zumbusch, Andreas; Holtom, Gary R.; Xie, X. Sunney. "Vibrational Microscopy Using Coherent Anti-Stokes Raman Scattering," Phys Rev Lett 82, 4142-4145 (1999).

Single Molecule Imaging

Zhou, Yuexin; Wang, Ping ; Tian, Feng; Gao, Ge; Huang, Lei; Wei, Wensheng; Xie, X. Sunney. "Painting a specific chromosome with CRISPR/Cas9 for live-cell imaging," Cell Res doi:10.1038/cr.2017.9 (2017).
Chong, Shasha; Min, Wei; Xie, X. Sunney. "Ground-State Depletion Microscopy:Detection Sensitivity of Single-Molecule Optical Absorption at Room Temperature,"J Phys Chem Lett 1, 3316-3322 (2010).
Min, Wei; Lu, Sijia; Chong, Shasha; Roy, Rahul; Holtom, Gary R.; Xie, X. Sunney. "Imaging Chromophores with Undetectable Fluorescence by Stimulated Emission Microscopy," Nature 461, 1105-1109 (2009).
Sánchez, Erik J.; Novotny, Lukas; Xie, X. Sunney. "Near-field Fluorescence Microscopy Based on Two-photon Excitation with Metal Tips," Phys Rev Lett 82, 4014-4017 (1999).
Sánchez, Erik J.; Novotny, Lukas; Holtom, G.R.; Xie, X. Sunney. "Room-Temperature Fluorescence Imaging and Spectroscopy of Single Molecules by Two-Photon Excitation," J Phys Chem A 101, 7019-7023 (1997).
Xie, X. Sunney; Dunn, Robert C. "Probing Single Molecule Dynamics," Science 265, 361-364 (1994).

References

External links

Homepage of the Xie Group at Harvard

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