Xian Jun Loh

Xian Jun Loh
Born Xian Jun Loh
1981
Singapore
Residence Singapore
Nationality Singaporean
Fields Thermogelling polymers, Drug Delivery Systems
Institutions Institute of Materials Research and Engineering (IMRE),
Agency for Science, Technology and Research (A*Star)
Alma mater National University of Singapore
Doctoral advisor Jun Li[1]
Known for Thermogelling polymers
Xian Jun Loh delivering Rising Star Award lecture at the Symposium on Innovative Polymers for Controlled Delivery (SIPCD) 2016 in Suzhou, China

Xian Jun Loh (Chinese: 罗贤俊; pinyin: Lúo Xián Jùn; born 1981) is a polymer chemist and author working in the inter-disciplinary field of biomaterials. He is an assistant professor at the National University of Singapore and a senior scientist at the Agency for Science, Technology and Research's Institute of Materials Research and Engineering (A*STAR's IMRE).[2][3] He has published more than 150 papers in journals such as Journal of the American Chemical Society, Advanced Materials, Chemical Communications and Biomaterials (a total of over 5400 citations, h-index of 41, and i-10 index of 100).[4]He has given numerous talks throughout Asia, the US, and Europe. Passionate about passing his experience on to younger scientists, he participated as a speaker at an event titled “Research Tracks in A*STAR” as a part of their Career Development Symposium series organized by the A*PECSS (A*STAR Postdoc and Early Career Scientist Society). He mentioned that "A*STAR is the best place to be in terms of career development".[5] His work has been used and applied in biomedical, household care and cosmetic industries.[6][7]

Education

Xian Jun Loh received his first class honors degree in Applied Chemistry from the National University of Singapore in 2006.[8] He received his PhD from the National University of Singapore and graduated in 2009 with a paper entitled “Smart Biomaterials”.[9]

Awards

Research Work

Xian Jun Loh's work is primarily on supramolecular hydrogels and thermogels. In 2012, he has been credited together with Oren Scherman and Eric Appel with the development of a cucurbituril containing supramolecular hydrogel that has been shown to sustain the release of drugs for up to six months in the lab.[17][18] He has also developed a thermogelling polymer based on polyhydroxybutyrate. This new biodegradable injectable system is able to encapsulate drugs for a period of three months and can be locally delivered to "a rodent model of hepatocarcinoma".[19][20] He has also recently developed a dual responsive gelling polymer which is responsive to both light and heat. This new material is able to stiffen upon exposure to elevated temperatures or UV light.[21][22] He is also working on a drug-delivery system for the delivery of a dengue vaccine with experts at the Singapore Immunology Network.[23] He is also credited with leading the development of an antimicrobial polymer that is 30 times more effective than conventional drugs.[24] Together with Prof Yoshihiro Ito from RIKEN, he has successfully pioneered a new method of cell detachment using a novel temperature-sensitive biomaterial. While the conventional process needs complicated fabrication methods, the new approach uses an easy “Drop-and-Dry” coating method which is useful for non-chemists to develop their own temperature responsive cell culture surface.[25] He also designed injectable supramolecular hydrogels based on MPEG-PCL-PEI/α-CD for the sustained delivery of a genetic material that can effectively inhibit tumor growth in mice.[26]

Books

Editorial Board

References

  1. ↑ "Department of Biomedical Engineering, National University of Singapore".
  2. ↑ "Institute of Materials Research and Engineering (IMRE) > Talent".
  3. ↑ "Department of Materials Science and Engineering - NUS".
  4. ↑ "Xian Jun Loh - Google Scholar Citations". Retrieved 2017-05-01.
  5. ↑ "[Media Coverage] Career Development Platforms within A*STAR – Research Tracks in A*STAR". 15 April 2015.
  6. ↑ "A*STAR & LION To Develop New Anti-Microbial Products". 23 May 2014.
  7. ↑ "ESTETICA USHERS IN A NEW ERA AFTER 35 YEARS IN THE BEAUTY BUSINESS - FLiPTV ASIA". 1 April 2015.
  8. ↑ "LOH Xian Jun - Department of Materials Science and Engineering - NUS". National University of Singapore. Retrieved 2017-05-01.
  9. ↑ "LOH Xian Jun - Department of Materials Science and Engineering - NUS". National University of Singapore. Retrieved 2017-05-01.
  10. 1 2 "Student Awards". Singapore National Institute of Chemistry. Retrieved 2017-05-01.
  11. ↑ "Anti-cancer Smart ‘Bomb’ Scientist Elected Fellow at Fitzwilliam > Agency for Science Technology and Research (A*STAR)".
  12. ↑ "Institute of Materials Research and Engineering Talent Page > Agency for Science Technology and Research (A*STAR)".
  13. ↑ "Institute of Materials Research and Engineering Talent Page > Agency for Science Technology and Research (A*STAR)". Retrieved 2017-05-01.
  14. ↑ "Institute of Materials Research and Engineering Talent Page > Agency for Science Technology and Research (A*STAR)". Retrieved 2017-05-01.
  15. ↑ "Symposium on Innovative Polymers for Controlled Delivery - Rising Stars Announced> 4th Symposium on Innovative Polymers for Controlled Delivery". Retrieved 2017-05-01.
  16. ↑ "Institute of Materials Research and Engineering Talent Page > Agency for Science Technology and Research (A*STAR)". Retrieved 2017-06-07.
  17. ↑ "New technology delivers sustained release of drugs for up to six months - Cambridge Enterprise". University of Cambridge. Retrieved 2017-05-01.
  18. ↑ "New tech could free diabetics from daily jabs". Millennium Post. Retrieved 2017-05-01.
  19. ↑ "Injectable hydrogels for precise chemotherapy - Advanced Science News". Wiley-VCH. Retrieved 2017-05-01.
  20. ↑ Wu, Y.-L., Wang, H., Qiu, Y.-K., Liow, S. S., Li, Z. and Loh, X. J. (2016), PHB-Based Gels as Delivery Agents of Chemotherapeutics for the Effective Shrinkage of Tumors. Adv. Healthcare Mater., 5: 2679–2685.doi: 10.1002/adhm.201600723
  21. ↑ "Dual Responsive Gelling Polymer". Wiley-VCH. Retrieved 2017-05-01.
  22. ↑ Dou, Q., Liow, S. S., Weng, W. and Loh, X. J. (2016), Dual-responsive reversible photo/thermogelling polymers exhibiting high modulus change. J. Polym. Sci. Part A: Polym. Chem., 54: 2837–2844.doi: 10.1002/pola.28191
  23. ↑ "Creating opportunities for scientists to 'collide'". 20 October 2015.
  24. ↑ "本地研发 伤口抗菌新材料 效用高30倍". 12 September 2016.
  25. ↑ "A*STAR and RIKEN celebrate 10 years of research collaboration". 3 August 2015.
  26. ↑ "Cover Art – Featuring Cancer Therapy, Angiogenesis and Tissue Engineering". 15 June 2017.
  27. ↑ "Polymeric and Self Assembled Hydrogels". 19 November 2012. doi:10.1039/9781849735629.
  28. ↑ "In-Situ Gelling Polymers - For Biomedical Applications - Xian Jun Loh - Springer".
  29. ↑ "Polymers for Personal Care Products and Cosmetics". 28 July 2016. doi:10.1039/9781782623984.
  30. ↑ "Gels - Editorial Board". MDPI. Retrieved 2017-05-01.
  31. ↑ "Materials - Associate Editors". Royal Society of Chemistry. Retrieved 2017-05-01.
  32. ↑ "Editorial Advisory Panel and Editorial Board". Nature Publishing Group. Retrieved 2017-05-01.
  33. ↑ "10 - Heliyon - Editorial board". Elsevier. Retrieved 2017-05-01.
  34. ↑ "Materials Science and Engineering: C Editorial Board". Elsevier. Retrieved 2017-05-01.
  35. ↑ "Material Chemistry Frontier". RSC. Retrieved 2017-06-27.
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