XPO5

XPO5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesXPO5, exp5, exportin 5
External IDsMGI: 1913789 HomoloGene: 69316 GeneCards: XPO5
Gene location (Human)
Chr.Chromosome 6 (human)[1]
BandNo data availableStart43,522,330 bp[1]
End43,576,075 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

57510

72322

Ensembl

ENSG00000124571

ENSMUSG00000067150

UniProt

Q9HAV4

Q924C1

RefSeq (mRNA)

NM_020750

NM_028198

RefSeq (protein)

NP_065801

NP_082474

Location (UCSC)Chr 6: 43.52 – 43.58 MbChr 6: 46.2 – 46.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Exportin-5 (XPO5) is a protein that in humans is encoded by the XPO5 gene.[5][6][7]

Exportin-5 is a member of the karyopherin family.[7] In metazoa, it is involved in transport of pre-microRNA out of the nucleus, where such molecules are generated by the Microprocessor complex, and into the cytoplasm for further processing by the Dicer enzyme.[8][9][10][11]

The plant homolog is called HASTY; although it is known to be required for the miRNA biogenesis pathway, its role in nuclear export is less clear than it is in animals.[12]

Interactions

XPO5 has been shown to interact with ILF3[5] and Ran.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000124571 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000067150 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 3 Brownawell AM, Macara IG (Jan 2002). "Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins". The Journal of Cell Biology. 156 (1): 53–64. PMC 2173575 Freely accessible. PMID 11777942. doi:10.1083/jcb.200110082.
  6. ↑ Bohnsack MT, Regener K, Schwappach B, Saffrich R, Paraskeva E, Hartmann E, Görlich D (Nov 2002). "Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm". The EMBO Journal. 21 (22): 6205–15. PMC 137205 Freely accessible. PMID 12426392. doi:10.1093/emboj/cdf613.
  7. 1 2 "Entrez Gene: XPO5 exportin 5".
  8. ↑ Yi R, Qin Y, Macara IG, Cullen BR (Dec 2003). "Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs". Genes & Development. 17 (24): 3011–6. PMC 305252 Freely accessible. PMID 14681208. doi:10.1101/gad.1158803.
  9. ↑ Wilson RC, Doudna JA (2013). "Molecular mechanisms of RNA interference". Annual Review of Biophysics. 42: 217–39. PMID 23654304. doi:10.1146/annurev-biophys-083012-130404.
  10. ↑ Siomi H, Siomi MC (May 2010). "Posttranscriptional regulation of microRNA biogenesis in animals". Molecular Cell. 38 (3): 323–32. PMID 20471939. doi:10.1016/j.molcel.2010.03.013.
  11. ↑ Macias S, Cordiner RA, Cáceres JF (Aug 2013). "Cellular functions of the microprocessor". Biochemical Society Transactions. 41 (4): 838–43. PMID 23863141. doi:10.1042/BST20130011.
  12. ↑ Voinnet O (Feb 2009). "Origin, biogenesis, and activity of plant microRNAs". Cell. 136 (4): 669–87. PMID 19239888. doi:10.1016/j.cell.2009.01.046.

Further reading

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