WNT1

WNT1
Identifiers
AliasesWNT1, BMND16, INT1, OI15, Wnt family member 1
External IDsMGI: 98953 HomoloGene: 3963 GeneCards: WNT1
Gene location (Human)
Chr.Chromosome 12 (human)[1]
BandNo data availableStart48,978,453 bp[1]
End48,981,676 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

7471

22408

Ensembl

ENSG00000125084

ENSMUSG00000022997

UniProt

P04628

P04426

RefSeq (mRNA)

NM_005430

NM_021279

RefSeq (protein)

NP_005421

NP_067254

Location (UCSC)Chr 12: 48.98 – 48.98 MbChr 12: 98.79 – 98.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Proto-oncogene protein Wnt-1 is a protein that in humans is encoded by the WNT1 gene.[5][6]

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region.[7]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000125084 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022997 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ van Ooyen A, Kwee V, Nusse R (Jan 1986). "The nucleotide sequence of the human int-1 mammary oncogene; evolutionary conservation of coding and non-coding sequences". EMBO J. 4 (11): 2905–9. PMC 554596 Freely accessible. PMID 2998762.
  6. ↑ Arheden K, Mandahl N, Strombeck B, Isaksson M, Mitelman F (May 1988). "Chromosome localization of the human oncogene INT1 to 12q13 by in situ hybridization". Cytogenet Cell Genet. 47 (1–2): 86–87. PMID 3281802. doi:10.1159/000132513.
  7. ↑ "Entrez Gene: WNT1 wingless-type MMTV integration site family, member 1".

Further reading

  • McMahon AP, Moon RT (1990). "int-1--a proto-oncogene involved in cell signalling". Development. 107 Suppl: 161–7. PMID 2534596. 
  • Chance PF, Cavalier L, Satran D, et al. (1999). "Clinical nosologic and genetic aspects of Joubert and related syndromes". J. Child Neurol. 14 (10): 660–666. PMID 10511339. doi:10.1177/088307389901401007. 
  • De Ferrari GV, Moon RT (2007). "The ups and downs of Wnt signaling in prevalent neurological disorders". Oncogene. 25 (57): 7545–7553. PMID 17143299. doi:10.1038/sj.onc.1210064. 
  • Thomas KR, Capecchi MR (1990). "Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development". Nature. 346 (6287): 847–850. PMID 2202907. doi:10.1038/346847a0. 
  • Turc-Carel C, Pietrzak E, Kakati S, et al. (1988). "The human int-1 gene is located at chromosome region 12q12-12q13 and is not rearranged in myxoid liposarcoma with t(12;16) (q13;p11)". Oncogene Res. 1 (4): 397–405. PMID 3329717. 
  • Wang YK, Samos CH, Peoples R, et al. (1997). "A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23". Hum. Mol. Genet. 6 (3): 465–472. PMID 9147651. doi:10.1093/hmg/6.3.465. 
  • Bafico A, Gazit A, Pramila T, et al. (1999). "Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling". J. Biol. Chem. 274 (23): 16180–16187. PMID 10347172. doi:10.1074/jbc.274.23.16180. 
  • Gazit A, Yaniv A, Bafico A, et al. (1999). "Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response". Oncogene. 18 (44): 5959–5966. PMID 10557084. doi:10.1038/sj.onc.1202985. 
  • Lee CS, Buttitta LA, May NR, et al. (2000). "SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm". Development. 127 (1): 109–18. PMID 10654605. 
  • Tanaka K, Okabayashi K, Asashima M, et al. (2000). "The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family". Eur. J. Biochem. 267 (13): 4300–4311. PMID 10866835. doi:10.1046/j.1432-1033.2000.01478.x. 
  • Tamai K, Semenov M, Kato Y, et al. (2000). "LDL-receptor-related proteins in Wnt signal transduction". Nature. 407 (6803): 530–535. PMID 11029007. doi:10.1038/35035117. 
  • Mao J, Wang J, Liu B, et al. (2001). "Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway". Mol. Cell. 7 (4): 801–809. PMID 11336703. doi:10.1016/S1097-2765(01)00224-6. 
  • Kirikoshi H, Sekihara H, Katoh M (2001). "WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly coexpressed in SW480 cells". Biochem. Biophys. Res. Commun. 283 (4): 798–805. PMID 11350055. doi:10.1006/bbrc.2001.4855. 
  • Semënov MV, Tamai K, Brott BK, et al. (2001). "Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6". Curr. Biol. 11 (12): 951–961. PMID 11448771. doi:10.1016/S0960-9822(01)00290-1. 
  • Mizushima T, Nakagawa H, Kamberov YG, et al. (2002). "Wnt-1 but not epidermal growth factor induces beta-catenin/T-cell factor-dependent transcription in esophageal cancer cells". Cancer Res. 62 (1): 277–82. PMID 11782388. 
  • Tice DA, Szeto W, Soloviev I, et al. (2002). "Synergistic induction of tumor antigens by Wnt-1 signaling and retinoic acid revealed by gene expression profiling". J. Biol. Chem. 277 (16): 14329–14335. PMID 11832495. doi:10.1074/jbc.M200334200. 


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