Von Hippel–Lindau binding protein 1

von Hippel-Lindau binding protein 1
Identifiers
Symbol VBP1
Entrez 7411
HUGO 12662
OMIM 300133
RefSeq NM_003372
UniProt P61758
Other data
Locus Chr. X q28

Von Hippel–Lindau binding protein 1 (VBP1), also known as "prefoldin 3", is a chaperone protein that binds to von Hippel–Lindau protein and transports it from perinuclear granules to the nucleus or cytoplasm inside the cell.[1] It is also involved in transporting nascent polypeptides to cytosolic chaperonins for post-translational folding.[2]

VBP1 is a 197–amino acid heterohexamer comprising two prefoldin-α and four prefoldin-β subunits,[2] and is a member of the prefoldin-α subunit family.[3] It is ubiquitously expressed in tissues, and is located in the cell in the nucleus and cytoplasm.[3] The VBP1 gene is located at Xq28.[4] Homologues are known to exist between human VBP1 and proteins in mice, Drosophila and C. elegans.[2]

See also

References

  1. ↑ Tsuchiya H, Iseda T & Hino O (1996). "Identification of a novel protein (VBP-1) binding to the von Hippel–Lindau (VHL) tumor suppressor gene product". Cancer Research. 56 (13): 2881–5. PMID 8674032.
  2. 1 2 3 "GenAtlas report: VBP1". 2003-01-17. Retrieved 2007-07-17.
  3. 1 2 "NiceProt report: P61758 (Prefoldin 3, human)". 2007-07-10. Retrieved 2007-07-17.
  4. ↑ Brinke A, Green PM & Giannelli F (1997). "Characterization of the gene (VBP1) and transcript for the von Hippel–Lindau binding protein and isolation of the highly conserved murine homologue". Genomics. 45 (1): 105–12. PMID 9339366. doi:10.1006/geno.1997.4902.



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