VN1R1

Identifiers

VN1R1, V1RL1, VNR19I1, ZVNH1, ZVNR1, vomeronasal 1 receptor 1

External IDs

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	No data available	Start	57,454,790 bp^[1]
Band	No data available	End	57,457,142 bp^[1]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• G-protein coupled receptor activity • pheromone receptor activity • signal transducer activity
Cellular component	• integral component of membrane • plasma membrane • membrane
Biological process	• G-protein coupled receptor signaling pathway • response to pheromone • signal transduction • sensory perception of chemical stimulus
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


57191


n/a

Ensembl


ENSG00000178201


n/a

UniProt


Q9GZP7


n/a

RefSeq (mRNA)


NM_020633


n/a

RefSeq (protein)


NP_065684


n/a

Location (UCSC)

Chr 19: 57.45 – 57.46 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

Vomeronasal type-1 receptor 1 is a protein that in humans is encoded by the VN1R1 gene.^[3]^[4]

Pheromones are chemical signals that elicit specific behavioral responses and physiologic alterations in recipients of the same species. The protein encoded by this gene is similar to pheromone receptors and is primarily localized to the olfactory mucosa. An alternate splice variant of this gene is thought to exist, but its full length nature has not been determined.^[4]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000178201 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ Rodriguez I, Greer CA, Mok MY, Mombaerts P (Oct 2000). "A putative pheromone receptor gene expressed in human olfactory mucosa". Nat Genet. 26 (1): 18–9. PMID 10973240. doi:10.1038/79124.
1 2 "Entrez Gene: VN1R1 vomeronasal 1 receptor 1".

Giorgi D, Friedman C, Trask BJ, Rouquier S (2001). "Characterization of nonfunctional V1R-like pheromone receptor sequences in human". Genome Res. 10 (12): 1979–85. PMC 313059 . PMID 11116092. doi:10.1101/gr.10.12.1979.
Pantages E, Dulac C (2001). "A novel family of candidate pheromone receptors in mammals". Neuron. 28 (3): 835–45. PMID 11163270. doi:10.1016/S0896-6273(00)00157-4.
Takeda S, Kadowaki S, Haga T, et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1–3): 97–101. PMID 12044878. doi:10.1016/S0014-5793(02)02775-8.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Zhang J, Webb DM (2003). "Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates". Proc. Natl. Acad. Sci. U.S.A. 100 (14): 8337–41. PMC 166230 . PMID 12826614. doi:10.1073/pnas.1331721100.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Mitropoulos C, Papachatzopoulou A, Menounos PG, et al. (2007). "Association study of human VN1R1 pheromone receptor gene alleles and gender". Genet. Test. 11 (2): 128–32. PMID 17627382. doi:10.1089/gte.2006.0516.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Cell surface receptor: G protein–coupled receptors

Class A: Rhodopsin-like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but 5-HT3) 5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 3 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 1 2 FPRL1 OXE Prostaglandin DP (1 2), EP (1 2 3 4), FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid (CB1 CB2, GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Lactate Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Niacin (1 2) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide

B/W (1
2)
FF (1
2)
S
Y (1
2
4
5)
Neuromedin (B
U (1
2))
Neurotensin (1
2)

Other

Anaphylatoxin (C3a
C5a)
Angiotensin (1
2)
Apelin
Bombesin
- BRS3
- GRPR
- NMBR)
- Bradykinin (B1
- B2)
Chemokine
Cholecystokinin (A
B)
Endothelin
- A
- B
Formyl peptide (1
2
3)
FSH
Galanin (1
2
3)
Gonadotropin-releasing hormone (1
2)
Ghrelin
Kisspeptin
Luteinizing hormone/choriogonadotropin
MAS (1
1L
D
E
F
G
X1
X2
X3
X4)
Melanocortin (1
2
3
4
5)
MCHR (1
2)
Motilin
Opioid (Delta
Kappa
Mu
Nociceptin & Zeta, but not Sigma)
Orexin (1
2)
Oxytocin
Prokineticin (1
2)
Prolactin-releasing peptide
Relaxin (1
2
3
4)
Somatostatin (1
2
3
4
5)
Tachykinin (1
2
3)
Thyrotropin
Thyrotropin-releasing hormone
Urotensin-II
Vasopressin (1A
1B
2)

Miscellaneous

Orphan	GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42 44 45 50 52 55 61 62 63 65 68 75 77 78 81 82 83 84 85 87 88 92 101 103 109A 109B 119 120 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)
Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B: Secretin-like

Adhesion	ADGRG (1 2 3 4 5 6 7)
Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)
Other	Brain-specific angiogenesis inhibitor (1 2 3) Cadherin (1 2 3) Calcitonin CALCRL CD97 Corticotropin-releasing hormone (1 2) EMR (1 2 3) Glucagon (GR GIPR GLP1R GLP2R) Growth-hormone-releasing hormone PACAPR1 GPR Latrophilin (1 2 3 ELTD1) Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C: Metabotropic glutamate / pheromone

Taste	TAS1R (1 2 3) TAS2R (1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor)
Other	Calcium-sensing receptor GABAB (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)

Class F: Frizzled / Smoothened

Frizzled	Frizzled (1 2 3 4 5 6 7 8 9 10)
Smoothened	Smoothened

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VN1R1

References

Further reading