Mitochondrial antiviral-signaling protein

MAVS

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2MS7, 2MS8, 3J6C, 3J6J, 3RC5, 4P4H, 4Z8M, 5JEK

Identifiers

Aliases

MAVS, CARDIF, IPS-1, IPS1, VISA, mitochondrial antiviral signaling protein

External IDs

MGI: 2444773 HomoloGene: 17004 GeneCards: MAVS

Gene location (Human)

Chr.	Chromosome 20 (human)^[1]

Band	No data available	Start	3,846,799 bp^[1]
Band	No data available	End	3,876,123 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	No data available	Start	131,234,063 bp^[2]
Band	No data available	End	131,248,025 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• signal transducer activity • protein binding • CARD domain binding • protein kinase binding
Cellular component	• integral component of membrane • mitochondrial membrane • membrane • peroxisomal membrane • peroxisome • mitochondrial outer membrane • mitochondrion
Biological process	• positive regulation of type I interferon-mediated signaling pathway • positive regulation of protein phosphorylation • positive regulation of protein import into nucleus, translocation • positive regulation of interferon-alpha production • immune system process • regulation of peroxisome organization • positive regulation of sequence-specific DNA binding transcription factor activity • positive regulation of IP-10 production • positive regulation of transcription factor import into nucleus • negative regulation of viral genome replication • defense response to bacterium • defense response to virus • positive regulation of chemokine (C-C motif) ligand 5 production • positive regulation of interleukin-8 production • cellular response to exogenous dsRNA • activation of innate immune response • positive regulation of tumor necrosis factor production • positive regulation of I-kappaB kinase/NF-kappaB signaling • negative regulation of type I interferon production • innate immune response • viral process • positive regulation of type I interferon production • signal transduction • RIG-I signaling pathway • positive regulation of transcription from RNA polymerase II promoter • positive regulation of defense response to virus by host • positive regulation of interferon-beta production • protein deubiquitination • positive regulation of interferon-beta secretion • positive regulation of response to cytokine stimulus • positive regulation of interferon-alpha secretion • positive regulation of tumor necrosis factor secretion • positive regulation of interleukin-6 secretion
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


57506


228607

Ensembl


ENSG00000088888


ENSMUSG00000037523

UniProt


Q7Z434


Q8VCF0

RefSeq (mRNA)


NM_001206491 NM_020746


NM_001206382 NM_001206383 NM_001206385 NM_144888

RefSeq (protein)


NP_001193420 NP_065797


NP_001193311 NP_001193312 NP_001193314 NP_659137

Location (UCSC)

Chr 20: 3.85 – 3.88 Mb

Chr 20: 131.23 – 131.25 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Mitochondrial antiviral-signaling protein (MAVS) is a protein that in humans is encoded by the MAVS gene.^[5]^[6]^[7] The protein is also known by the names VISA (virus-induced signaling adapter), IPS-1 and Cardif. Aggregated MAVS forms protease resistant prion-like aggregates that activate IRF3 dimerization.^[8]

Function

Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 or by the cytoplasmic RNA helicases MDA5 and RIGI. These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK) and IKKB (IKBKB; MIM 603258), which activate NFKB, or TBK1 and IKBKE (IKBKE), which activate IRF3. Activated IRF3 and NFKB induce transcription of IFNβ (IFNB1). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1). For RIGI, the intermediary protein is mitochondria-bound MAVS.^[7]^[9]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000088888 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037523 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Seth RB, Sun L, Ea CK, Chen ZJ (Sep 2005). "Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3". Cell. 122 (5): 669–82. PMID 16125763. doi:10.1016/j.cell.2005.08.012.
↑ Xu LG, Wang YY, Han KJ, Li LY, Zhai Z, Shu HB (Sep 2005). "VISA is an adapter protein required for virus-triggered IFN-beta signaling". Mol Cell. 19 (6): 727–40. PMID 16153868. doi:10.1016/j.molcel.2005.08.014.
1 2 "Entrez Gene: VISA virus-induced signaling adapter".
↑ Hou F, Sun L, Zheng H, Skaug B, Jiang QX, Chen ZJ (Aug 5, 2011). "MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response.". Cell. 146 (3): 448–61. PMC 3179916 . PMID 21782231. doi:10.1016/j.cell.2011.06.041.
↑ Sen GC, Sarkar SN (2005). "Hitching RIG to action". Nat. Immunol. 6 (11): 1074–6. PMID 16239922. doi:10.1038/ni1105-1074.

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Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. PMID 16964243. doi:10.1038/nbt1240.
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Mitochondrial antiviral-signaling protein

Function

References

Further reading