VAP protein family

VAP proteins are conserved integral membrane proteins of the endoplasmic reticulum found in all eukaryotic cells.[1] VAP stands for VAMP-associated protein,[2] where VAMP stands for vesicle-associated membrane protein. Humans have two VAPs: VAPA and VAPB.[3] VAP is a useful umbrella term that can be applied to the whole family of proteins homologues in all species. For example, baker's yeast expresses two VAPs: Scs2 and Scs22.[4][5]

References

  1. ↑ Weir, M. L.; Klip, A.; Trimble, W. S. (1998-07-15). "Identification of a human homologue of the vesicle-associated membrane protein (VAMP)-associated protein of 33 kDa (VAP-33): a broadly expressed protein that binds to VAMP". The Biochemical Journal. 333 ( Pt 2): 247–251. ISSN 0264-6021. PMC 1219579 Freely accessible. PMID 9657962.
  2. ↑ Skehel, P. A.; Martin, K. C.; Kandel, E. R.; Bartsch, D. (1995-09-15). "A VAMP-binding protein from Aplysia required for neurotransmitter release". Science (New York, N.Y.). 269 (5230): 1580–1583. ISSN 0036-8075. PMID 7667638.
  3. ↑ Nishimura, Y.; Hayashi, M.; Inada, H.; Tanaka, T. (1999-01-08). "Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins". Biochemical and Biophysical Research Communications. 254 (1): 21–26. ISSN 0006-291X. PMID 9920726. doi:10.1006/bbrc.1998.9876.
  4. ↑ Nikawa, J.; Murakami, A.; Esumi, E.; Hosaka, K. (July 1995). "Cloning and sequence of the SCS2 gene, which can suppress the defect of INO1 expression in an inositol auxotrophic mutant of Saccharomyces cerevisiae". Journal of Biochemistry. 118 (1): 39–45. ISSN 0021-924X. PMID 8537323.
  5. ↑ Loewen, Christopher J. R.; Levine, Timothy P. (2005-04-08). "A highly conserved binding site in vesicle-associated membrane protein-associated protein (VAP) for the FFAT motif of lipid-binding proteins". The Journal of Biological Chemistry. 280 (14): 14097–14104. ISSN 0021-9258. PMID 15668246. doi:10.1074/jbc.M500147200.
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