Urumin
| Names | |
|---|---|
| Other names
IPLRGAFINGRWDSQCHRFSNGAIACA; H-Ile-Pro-Leu-Arg-Gly-Ala-Phe-Ile-Asn-Gly-Arg-Trp-Asp-Ser-Gln-Cys-His-Arg-Phe-Ser-Asn-Gly-Ala-Ile-Ala-Cys-Ala-OH | |
| Identifiers | |
| Properties | |
| C129H198N42O35S2 | |
| Molar mass | 2961.37 g/mol |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Urumin is a naturally occurring 27-amino acid virucidal host defense peptide against the human influenza A virus.[1] It is produced by the skin of Hydrophylax bahuvistara, a species of frog found in South India, and was discovered and isolated in 2017.[1] The peptide specifically targets the evolutionarily conserved H1 hemagglutinin stalk region of H1-containing influenza A viruses.[1] It is effective against drug-resistant influenza A viruses, physically destroying influenza A virions, and is able to protect naive mice from fatal influenza A infection.[1] Because of its specific targeting of the hemagglutinin stalk region of the influenza A virus, the mechanism of action of urumin is similar to that of antibodies induced in the body by universal influenza vaccines.[1] As such, urumin may represent the basis for a potential first-line antiviral treatment against influenza A, particularly in the context of influenza outbreaks.[1]
References
- 1 2 3 4 5 6 Holthausen DJ, Lee SH, Kumar VT, Bouvier NM, Krammer F, Ellebedy AH, Wrammert J, Lowen AC, George S, Pillai MR, Jacob J (2017). "An Amphibian Host Defense Peptide Is Virucidal for Human H1 Hemagglutinin-Bearing Influenza Viruses". Immunity. 46 (4): 587–595. PMID 28423338. doi:10.1016/j.immuni.2017.03.018.