Urea carboxylase
| urea carboxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 6.3.4.6 | ||||||||
| CAS number | 9058-98-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
| |||||||||
In enzymology, an urea carboxylase (EC 6.3.4.6) is an enzyme that catalyzes the chemical reaction
- ATP + urea + HCO3- ADP + phosphate + urea-1-carboxylate
The 3 substrates of this enzyme are ATP, urea, and HCO3-, whereas its 3 products are ADP, phosphate, and urea-1-carboxylate (allophanate).
This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is urea:carbon-dioxide ligase (ADP-forming). Other names in common use include urease (ATP-hydrolysing), urea carboxylase (hydrolysing), ATP-urea amidolyase, urea amidolyase, UALase, and UCA. This enzyme participates in urea cycle and metabolism of amino groups. It employs one cofactor, biotin.
See also
References
- Roon RJ; Levenberg B (1970). "ATP-Urea amidolyase (ADP) (Candida utilis)". Methods Enzymol. 17A: 317–324. doi:10.1016/0076-6879(71)17204-7.
- Roon RJ, Levenberg B (1972). "Urea amidolyase. I. Properties of the enzyme from Candida utilis". J. Biol. Chem. 247 (13): 4107–13. PMID 4556303.
- Sumrada RA, Cooper TG (1982). "Urea carboxylase and allophanate hydrolase are components of a multifunctional protein in yeast". J. Biol. Chem. 257 (15): 9119–27. PMID 6124544.
- Kanamori T, Kanou N, Atomi H, Imanaka T (2004). "Enzymatic characterization of a prokaryotic urea carboxylase". J. Bacteriol. 186 (9): 2532–9. PMC 387783
. PMID 15090492. doi:10.1128/JB.186.9.2532-2539.2004.
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