University of Texas Southwestern Medical Center

The University of Texas Southwestern Medical Center

Type	Public
Established	1943
Endowment	$1.01 billion (April 2017) [1]
President	Daniel K. Podolsky, M.D.
Dean	J. Gregory Fitz, M.D.
Academic staff	3691 (1,394 full-time, 402 part-time, 1,755 voluntary, 110 faculty associates, and 30 administrators)
Administrative staff	7103
Postgraduates	3255
Location	Dallas, Texas, US 32°48′45″N 96°50′18″W / 32.8126058°N 96.8384102°W / 32.8126058; -96.8384102Coordinates: 32°48′45″N 96°50′18″W / 32.8126058°N 96.8384102°W / 32.8126058; -96.8384102
Campus	Urban, 231 acres (0.9 km2)
Website	www.utsouthwestern.edu

The University of Texas Southwestern Medical Center (UT Southwestern) is a medical education and biomedical research institution in the United States. It is located in the Southwestern Medical District, a 1,000 plus-acre campus in Dallas that incorporates three degree-granting institutions – UT Southwestern Medical School, UT Southwestern Graduate School of Biomedical Sciences, UT Southwestern School of Health Professions – along with four affiliated hospitals: Parkland Hospital, Children’s Health℠, Zale Lipshy University Hospital, and William P. Clements Jr. University Hospital.

One of the largest medical schools in the country, UT Southwestern annually trains about 3,700 medical, graduate, and health-professions students, residents, and postdoctoral fellows each year. Ongoing support from federal agencies, such as the National Institutes of Health, along with foundations, individuals, and corporations, provides approximately $422.6 million per year to fund more than 5,700 research projects.

UT Southwestern faculty physicians provide patient care at UT Southwestern University Hospitals & Clinics, Parkland Health & Hospital System, Children’s Medical Center, Texas Scottish Rite Hospital for Children, VA North Texas Health Care System, and other affiliated hospitals and community clinics. Faculty and residents care for more than 100,000 hospitalized patients and oversee approximately 2.2 million outpatient visits a year, providing more than $106.7 million in unreimbursed clinical services annually.

In the spring of 2016, UT Southwestern began providing additional care through a new, clinically integrated health care network called Southwestern Health Resources, which blends the systems of Texas Health Resources and UT Southwestern to provide increased access to primary and specialized care to North Texas residents, from preventive measures to advanced interventions. The network comprises 27 hospitals, 300 clinics, and more than 2,000 physicians, spanning a 16-county service area with more than 6 million residents.

UT Southwestern is one of approximately 60 academic health centers nationwide that are members of the Clinical and Translational Science Awards (CTSA) program, a national consortium of medical research institutions funded through the National Institutes of Health’s national Center for Research Resources. CTSAs encourage collaboration across scientific disciplines, train clinical and translational researchers, and drive innovative approaches to research challenges.

With approximately 14,400 employees and an operating budget of nearly $2.5 billion, UT Southwestern is one of six medical schools in the UT System. Its three-part mission is to: educate the next generation of leaders in patient care, biomedical science, and disease prevention; conduct high-impact research; and deliver patient care that brings UTSW’s scientific advances to the bedside – focusing on quality, safety, and service.

History

Establishment

Under the leadership of Dr. Edward H. Cary and Karl Hoblitzelle, a group of prominent Dallas citizens organized Southwestern Medical Foundation in 1939 to promote medical education and research in Dallas and the region. When Baylor University elected to move its school of medicine from Dallas to Houston in 1943, the foundation formally established Southwestern Medical College as the 68th medical school in the United States. Founded during World War II, the medical school was initially housed in a handful of abandoned barracks.

Affiliation with University of Texas

When a new state medical school was proposed after World War II, leaders of Southwestern Medical Foundation offered the college's equipment, library, and certain restricted funds to the University of Texas System, provided the university would locate its new medical branch in Dallas. The Board of Regents accepted this offer from the foundation, and in 1949 the college became Southwestern Medical School of The University of Texas. In 1954 the name was changed to The University of Texas Southwestern Medical School. The present campus site on Harry Hines Boulevard was occupied in 1955 upon the completion of the Edward H. Cary Building. This placed the medical school faculty next to the then-newly built Parkland Memorial Hospital.

Reorganization

In November 1972 the name and scope of the medical school were changed with its reorganization into The University of Texas Health Science Center at Dallas. In approving the concept of a health science center, the Board of Regents provided for the continued growth of coordinated but separate medical, graduate, and undergraduate components, interacting creatively on the problems of human health and well-being.

Addition of Howard Hughes Medical Institute

In 1986 the Howard Hughes Medical Institute opened a research facility on the campus. Concentrating on molecular biology, it has brought outstanding scientists to head laboratories in their specialties. These Investigators also hold faculty positions in the basic science departments of the Medical School and Graduate School. Counted among the nation’s largest philanthropies, HHMI has provided almost $8 billion in direct support over the past decade alone for research and science education for the country’s most creative and promising scientists.

In October 1987 the UT System Board of Regents approved changing the name of the health science center to The University of Texas Southwestern Medical Center at Dallas, reconfirming its original Southwestern identity. The Medical Center encompasses three degree-granting institutions: UT Southwestern Medical School, UT Southwestern Graduate School of Biomedical Sciences, and UT Southwestern School of Health Professions.

Physical expansion

Since the late 1960s the university has added more than 6 million square feet of new construction. The 60-acre South Campus includes 20 buildings housing classrooms, laboratories, offices, the extensive University of Texas Southwestern Medical Center Library, an auditorium, and a large outpatient center. Affiliated hospitals adjacent to the campus are Zale Lipshy University Hospital, Parkland Memorial Hospital, William P. Clements Jr. University Hospital, and Children's Medical Center (Dallas).

In 1987 the John D. and Catherine T. MacArthur Foundation gave the university 30 acres (120,000 m²) near the South Campus for future expansion. A 20-year master plan for the site, called North Campus, calls for six research towers, a support-services building, an energy plant, and underground parking, in addition to the Mary Nell and Ralph B. Rogers Magnetic Resonance Center and the Moncrief Radiation Oncology Center. Three research towers and an elevated campus connector, linking the South Campus with the North Campus, were completed in the 1990s. A fourth 14-story research tower was completed in 2005, followed by a 12-story research tower in 2011. In 1999 the university purchased an additional 50 acres from the MacArthur Foundation, and a portion of the property was used to create an on-campus student-housing complex of 156 apartments. A second phase of 126 units opened in the summer of 2004. In 2008, the university purchased the 24-acre Exchange Park adjacent to the North Campus.

In 2008, UT Southwestern opened the BioCenter at Southwestern Medical District, a multitenant facility meant to help commercialize university technologies and attract biotech companies to the area. Next door to the BioCenter, UTSW will in 2017 open its Radiation Oncology center, a $66 million facility with three floors, 63,000 square feet of space, seven patient treatment rooms, and technology for targeting tumors with radiation therapy.

Clinical services

The clinical services are expanding as annual patient visits to the Medical Center’s clinics average 400,000 a year, up from 50,000 annually 15 years ago. UT Southwestern includes affiliated patient care facilities such as the UT Southwestern University Hospitals, and the Harold C. Simmons Comprehensive Cancer Center, which is a National Cancer Institute (NCI)-designated Cancer Center. There, physicians treat every cancer, from breast, urologic, gynecologic, lung, gastrointestinal, head and neck, brain, and skin to lymphomas, leukemia, and bone marrow transplantation.

UT Southwestern also is an Advanced Comprehensive Stroke Center, the highest level of certification for stroke care. UT Southwestern’s Robert D. Rogers Advanced Comprehensive Stroke Center is the only Joint Commission-certified Advanced Comprehensive Stroke Center in North Texas; it is one of only three such centers in Texas and also is certified by the American Heart Association and the American Stroke Association.

Clinicians and researchers work together to treat and to find the root causes of Parkinson’s disease, multiple sclerosis, amyotrophic lateral sclerosis, epilepsy, and peripheral nerve injuries. The Medical Center also is home to an NIH Alzheimer’s Disease Center and is a Network of Excellence in Neuroscience Clinical Trials Center.

The Doris and Harry W. Bass Jr. Clinical Center for heart, Lung, and Vascular Disease is a collaborative effort between UT Southwestern faculty and community physicians. It provides care for adult congenital heart disease patients, as well as cardiac imaging, cardiovascular and thoracic surgery, electrophysiology, general cardiology, heart failure care, heart and lung transplant, interventional cardiology, interventional radiology, lung transplant pulmonology, mechanical circulatory assistance, preventive cardiology, pulmonary hypertension care, and vascular and endovascular surgery.

UT Southwestern’s transplantation programs for heart, lung, kidney, and liver have been certified by the federal government’s Centers for Medicare & Medicaid Services. This certification ensures broad access to the full range of related fields, including surgery, infection control, immunity, and rejection. Surgeons from UT Southwestern performed North Texas’ first kidney transplant in 1964 and are responsible for many innovations that have become the accepted practice throughout the nation.

Academics

UT Southwestern is governed by the UT Board of Regents. The Medical Center includes three degree-granting institutions/schools: UT Southwestern Medical School, UT Southwestern Graduate School of Biomedical Sciences, and UT Southwestern School of Health Professions. Throughout its history, UT Southwestern has graduated approximately 20,000 physicians and other professionals in all areas of medicine. In 2016 alone, UTSW faculty is training about 3,700 medical, graduate, and health professions students, residents, and postdoctoral fellows.

UT Southwestern Medical School

UT Southwestern admits approximately 230 students each year. The average MCAT score is 34, and undergraduate GPA in 2014 was 3.88. The acceptance rate for 2014 was 5.6%.

UTSW is one of the five least-expensive public medical schools and among the top 10 largest medical schools in the United States. The school's tuition and fees are approximately $20,000 per year for in-state residents, being subsidized by the state. Admission is competitive and, by mandate of the state legislature, 90 percent of applicants admitted are from the state of Texas, in order to ensure the state a consistent source of high-quality physicians. Many out-of-state students earn competitive scholarships that make up the difference.

The Medical School’s curriculum emphasizes clinical experience and electives from the first year on. The curriculum comprises three distinct periods – Pre-Clerkship, Clerkship, and Post-Clerkship – and focuses on providing a foundation in biomedical sciences, training in clinical care, and opportunities for research.

The Medical School features six Academic Colleges that function as small learning communities, each headed by a faculty mentor. Small groups of students meet with their mentors to discuss important areas such as ethics, case-based learning, and medical professionalism, and they have the opportunity to observe their mentors in action and mirror the clinical skills, behaviors, and attitudes of experienced physicians.

Many students use their free time to participate in a variety of community service activities, such as United to Serve, which is an annual health and fun fair hosted by UT Southwestern for the surrounding community, and the weekly Monday Clinic (one of six clinics), which is organized by student volunteers and staffed by UT Southwestern physicians, providing free medical care to underserved Dallas communities. Other service opportunities include participating at Camp Sweeney, a summer camp in North Texas for children with diabetes.

Along with the M.D. degree, UT Southwestern offers options for students to pursue combined degrees and to earn special graduation distinctions. The combined degrees include:

· M.D./Ph.D. – Called the Medical Scientist Training Program (MSTP), this is one of fewer than 50 M.D./Ph.D.-granting programs nationwide that receive financial support from the National Institutes of Health. It combines dissertation work in an area of biomedical science, leading to the Ph.D., along with clinical studies, leading to the M.D.

· M.D./M.B.A. – This five-year program in conjunction with UT Dallas focuses on giving future physicians the skill sets for successfully integrating medicine and business.

· M.D./M.P.H. – UT Southwestern and UTHealth School of Public Health in Houston offer students interested in medicine and public health an opportunity to be awarded a degree in each field at the end of their four-year M.D. program.

· M.D./M.S. in Clinical Science – This program combines rigorous didactic training with a mentored clinical research project. The program concludes with submission and defense of a master’s thesis.

Students who choose to do so can graduate with an M.D. with Distinction in multiple areas, including basic research, clinical and translational research, community health, global health, medical education, biomedical innovations, and quality improvement.

UT Southwestern is ranked 25th in Research and 8th in Primary Care according to the 2017 U.S. News & World Report Medical School rankings. It is one of 23 medical institutions to be within the top 25 for both research and primary care rankings.

Graduate School of Biomedical Sciences

According to the 2015 U.S. News & World Report containing the latest ranking for graduate schools of life sciences as of 2014, UT Southwestern is ranked 19th in the nation in Biological Sciences and 41st in Chemistry.^[7]

Specialties

1. 11th in Biochemistry/Biophysics/Structural Biology

2. 10th in Cell Biology

3. 9th in Immunology/Infectious Disease

4. 10th in Molecular Biology

The 2016 Academic Ranking of World Universities placed UTSW 9th in the world for Clinical Medicine and Pharmacy and 16th for Life and Agriculture Sciences.^[2][3]

Other ranking methodologies that aim to quantify the impact of publications rank UTSW among the top five biomedical research institutions in the nation.

With an enrollment of more than 1,000 students (467 predoctoral and 564 postdoctoral), the Graduate School educates biomedical scientists, engineers, clinical researchers, and counselors. Programs lead to Doctor of Philosophy and Master of Science degrees and, in some cases, non-degree certificates.

Future scientists are trained to investigate basic life processes from the molecule to the whole animal. The Graduate School has 12 Ph.D. programs: Biological Chemistry; Biomedical Engineering; Cancer Biology; Cell and Molecular Biology; Clinical Psychology; Genetics, Development, and Disease; Immunology; Integrative Biology; Molecular Biophysics; Molecular Microbiology; Neuroscience; and Organic Chemistry.

In addition, a master's degree and a certificate are offered in Clinical Science. Postdoctoral certificates are offered in Research, Advanced Research, Cancer, Educational Techniques, Obesity and Metabolism, and Scientific Management.

M.D./Ph.D. Program

UT Southwestern runs a competitive Medical Scientist Training Program (MSTP) that offers a combined M.D./Ph.D. degree. It is one of fewer than 50 M.D./Ph.D.-granting programs nationwide that receive financial support from the National Institutes of Health. The largest source of private support for UTSW's program has been from H. Ross Perot.^[10] Dr. Michael Brown, Nobel laureate, is involved with the administration of UTSW’s program and attends the weekly "Works-in-Progress" talks given by research faculty.

The clinical training curriculum includes coursework in the elemental disciplines necessary to understand human disease at the level of cellular physiology and biochemistry. In addition, students practice and hone clinical skills at UT Southwestern’s affiliated clinical training hospitals, including Parkland Memorial Hospital and William P. Clements Jr. University Hospital.

Following summer laboratory rotations, MSTP students choose from one of 10 interdepartmental graduate programs and select a dissertation mentor from among any member of the UT Southwestern Graduate School faculty for training in intellectual and experimental strategies. During these years, the MSTP student functions as a graduate student in his or her laboratory while maintaining an awareness of clinical medicine through program activities.

Dissertation research culminates in results that significantly advance the state of biomedical knowledge.

School of Health Professions

About 340 students are enrolled in UT Southwestern’s School of Health Professions. The school confers a doctoral professional degree in Physical Therapy and master's degrees in Clinical Nutrition, Physician Assistant Studies, Prosthetics-Orthotics, and Rehabilitation Counseling. The school also has a baccalaureate certificate program in Radiation Therapy.

The Physician Assistant program was founded in 1972. For the past five years, graduates have had a 100 percent first-time pass rate on the national certifying exam. Much of the training occurs at Parkland Memorial Hospital.^[11]

Library

The Health Sciences Digital Library and Learning Center supports the information needs of UT Southwestern's research, educational, and clinical activities. The Library and Learning Center maintains a large collection of electronic information resources, print archives, rare books, and materials concerning the history of medicine. It also offers assistance and training in using these resources. The library also has a small branch library on the North Campus.^[12]

Research

UT Southwestern scientists and physician researchers actively conduct investigations into cancer, neuroscience, heart disease and stroke, arthritis, diabetes, and many other fields.

At the new Peter O’Donnell Jr. Brain Institute on campus, investigators are working to better understand the basic molecular workings of the brain and applying these discoveries to the prevention and treatment of the full range of brain diseases and injuries. The Institute’s scientists and clinicians cover neurodegenerative diseases; depression and psychiatric disorders; migraines; and spine, nerve, and muscle diseases. Also at the Institute are voice specialists, rehabilitation experts, and neuroimmunologists, plus numerous basic and translational scientists in cellular and molecular neuroscience, neurobiology, regenerative medicine, neuro-engineering, imaging, and genetics. [Source: Southwestern Medicine 2015 Annual Review]

Researchers at UTSW’s Harold C. Simmons Comprehensive Cancer Center – the only cancer center in North Texas to attain the National Cancer Institute’s comprehensive designation – are focusing on discovering drug-like chemicals that can impact processes that drive or inhibit cancer growth and deciphering mechanisms in cell regulatory networks that go awry and contribute to cancer initiation and growth. Cancer Center researchers in developmental biology, cancer biology, and stem cell biology are meanwhile shedding light on how developmental processes contribute to cancer’s progress.

UT Southwestern established the Hamon Center for Regenerative Science and Medicine in 2014 to advance human health through discoveries of the fundamental mechanisms of tissue formation and repair and to develop transformative strategies and medications to enhance tissue regeneration.

Research at UTSW’s Texas Institute for Brain Injury and Repair focuses on various types of brain injuries and conditions, including traumatic brain injury (TBI), stroke, and Alzheimer’s disease. The Institute also promotes brain injury education and prevention. The Texas Legislature provided $15 million for the current biennium – the largest allocation for a brain injury initiative in state history.

Other research currently underway at UT Southwestern includes studies on:

• Aging and Alzheimer’s – Work by Dr. Steven McKnight and colleagues identified a compound (P7C3) and demonstrated that it preserves newly created brain cells and boosts learning and memory. The study has led to further investigations into the mechanism by which P7C3 protects cells from dying and whether the compound might have any protective effect for various neurodegenerative diseases.
• Cancer/Biomarkers – Drs. John Minna and Adi Gazdar have spent the past 30 years elucidating the genetic changes associated with the development of lung cancer. Their work seeks to discover these changes and use them as biomarkers both to detect lung cancer earlier and to develop new therapies. Their approach is advancing personalized medicine, which aims to target the unique characteristics of an individual’s tumor with the best current therapies.
• Cancer/Stem Cells – A team led by Dr. Sean Morrison at the Children’s Medical Center Research Institute at UT Southwestern has identified the environment in which blood-forming stem cells survive and thrive within the body, an important step toward increasing the safety and effectiveness of bone marrow transplantation.
• Cardiology/Regeneration – Researchers, including Drs. Eric Olson and Hesham Sadek, have pinpointed a molecular mechanism needed to unleash the heart’s ability to regenerate. They found that microRNAs – tiny strands that regulate gene expression – contribute to the heart’s ability to regenerate up to one week after birth. Soon thereafter the heart loses the ability to regenerate. Identifying the heart’s natural regenerative on-off switch is a critical step toward developing eventual therapies for damage suffered following a heart attack. Dr. Olson’s lab has also used CRISPR/Cas9 methods to cure Duchenne muscular dystrophy in mice as a proof of principle for human gene therapy.
• Cholesterol – UT Southwestern researchers have identified nearly 30 disease-causing genes, including in 1983 the gene responsible for familial hypercholesterolemia, an inherited condition that causes extremely high levels of cholesterol and heart attacks at an early age. That discovery by Drs. Michael Brown and Joseph Goldstein contributed to the pair winning the 1985 Nobel Prize in Physiology or Medicine for their research uncovering the underlying mechanisms of cholesterol metabolism.
• Diabetes/Obesity – Dr. Philipp Scherer’s discovery of adiponectin, a hormone produced by fat, has helped transform the scientific concept of fat as an inert storage depot to that of an endocrine “organ” that exerts control over multiple organs. His studies have revealed adiponectin’s potent anti-diabetes effects of blocking glucose production in the liver and improving insulin sensitivity in muscle. Because adiponectin levels fall as fat levels rise, drugs that increase adiponectin may be effective in fighting diabetes and other obesity-related diseases.
• Human Genetics – Drs. Helen Hobbs and Jonathan Cohen are among the world’s leading experts on the genetic factors associated with lipid disorders. Their work, for which Dr. Hobbs received the 2016 Breakthrough Prize in Life Sciences, has led to the development of a new class of cholesterol-lowering drugs – PCSK9 antibodies – that are saving the lives of patients who do not tolerate or respond adequately to statins.
• Innate Immunity – Scientists led by Dr. Zhijian “James” Chen are exploring the mechanisms of signal transduction, namely how a cell communicates with its surroundings and within itself. They are focused on investigating how a cell detects harmful or foreign threats and mounts an appropriate response to restore homeostasis. Dr. Chen has made a number of seminal discoveries for which he was elected to the National Academy of Sciences, including the cytoplasmic DNA sensor cGAS and its product cGAMP, a novel cyclic dinucleotide second messenger involved in innate immune response. Dr. Bruce Beutler received the 2011 Nobel Prize in Physiology or Medicine for his discovery that the Toll-like receptor 4 (TLR4) is the membrane-spanning component of the mammalian lipopolysaccharide receptor complex that senses microbial infection and triggers septic shock. Dr. Beutler continues to identify components of the mammalian immune system through large-scale mouse mutagenesis screens conducted in the Center for the Genetics of Host Defense, which he leads.

Notable faculty

Six UT Southwestern faculty members have been awarded Nobel Prizes since 1985.

• In 1985, Dr. Michael Brown and Dr. Joseph Goldstein shared the Nobel Prize in Physiology or Medicine for their discovery of the basic mechanism of cholesterol metabolism. Dr. Goldstein is Chairman of Molecular Genetics at UT Southwestern, and Dr. Brown directs the Erik Jonsson Center for Research in Molecular Genetics and Human Disease.
• Dr. Johann Deisenhofer, Professor of Biochemistry and a Howard Hughes Medical Institute Investigator at UT Southwestern, shared the 1988 Nobel Prize in Chemistry for using X-ray crystallography to describe the structure of a protein involved in photosynthesis.
• The late Dr. Alfred Gilman shared the 1994 Nobel Prize in Physiology or Medicine for the discovery of G proteins and the role they play in the complex processes by which cells communicate with each other. Dr. Gilman, a Regental Professor Emeritus who died in December 2015, served in numerous leadership roles during his career, including as Chairman of Pharmacology and subsequently as Dean of UT Southwestern Medical School.
• Dr. Bruce Beutler, Director of the Center for the Genetics of Host Defense, shared the 2011 Nobel Prize in Physiology or Medicine with two other scientists for their immune system investigations. Dr. Beutler was honored for the discovery of receptor proteins that recognize disease-causing agents and activate innate immunity, the first step in the body’s immune response.
• Dr. Thomas C. Südhof, Adjunct Professor of Neuroscience and former Chair of the department at UT Southwestern, shared the 2013 Nobel Prize in Physiology or Medicine with two other scientists for their discoveries about how cellular transport systems work. Dr. Südhof, now at Stanford University School of Medicine, was recognized for his pioneering work performed at UT Southwestern on synaptic transmission, the process by which brain cells communicate with each other via chemical signals passed through the spaces, or synapses, between them.^[14]

Two current recipients of the Albert D. Lasker Award in Basic Medical Research

• 1985 Michael Brown, M.D.
• 1985 Joseph Goldstein, M.D.
• 1989 Alfred Gilman, M.D., Ph.D. (deceased)

Twenty-three current members of the National Academy of Sciences^[4]

• 1979 Ronald Estabrook, Ph.D. (deceased)

Eighteen current members of the National Academy of Medicine (formerly the Institute of Medicine^[4])

Sixteen members of the American Academy of Arts and Sciences^[4]

Thirteen current members of the Howard Hughes Medical Institute^[5]

UTSW's clinical faculty includes 58 specialists listed in" Best Doctors in America" and 230 included in "Best Doctors in America: Central Region".^[2]

Notable alumni

• James Atkins (M.D. 1967) UTSW Professor of Medicine
• Jim C. Barnett (M.D. 1949) (deceased 2013), Member of the Mississippi House of Representatives from 1992 to 2008.^[16]
• Linda B. Buck, (Ph.D. 1980) 2004 Nobel Laureate in Physiology or Medicine for work on olfactory receptors, currently an HHMI investigator at Fred Hutchinson Cancer Research Center
• Robert Cade, (M.D. 1954) (deceased 2007) professor of medicine and nephrology at the University of Florida, formulated Gatorade.
• Daniel Foster (M.D. 1955?) UTSW chairman department of medicine, holder of the UTSW John Denis McGarry, Ph.D., Distinguished Chair in Diabetes and Metabolic Research
• Norman Gant (M.D.) Former UTSW Chairman Department of Obstetrics and Gynecology
• Brett Giroir, (M.D. 1986), biomedical researcher, former Director of DARPA, current Vice Chancellor for Strategic Initiatives at the Texas A&M University System
• Joseph Goldstein, (M.D. 1966) is currently Chairman of the Department of Molecular Genetics at UTSW. In 1985, he was named Regental Professor of the University of Texas. He also holds the Paul J. Thomas Chair in Medicine and the Julie and Louis A. Beecherl Distinguished Chair in Biomedical Science. Dr. Goldstein and his colleague, Michael S. Brown, discovered the low-density lipoprotein (LDL) receptor and worked out how these receptors control cholesterol homeostasis. It helped lay the conceptual groundwork for development of statins that lower blood LDL-cholesterol and prevent heart attacks. Drs. Goldstein and Brown shared many awards for this work, including the Lasker Award in Basic Medical Research (1985), Nobel Prize in Physiology or Medicine (1985), and the National Medal of Science (1988). In recent work, Drs. Goldstein and Brown discovered the SREBP family of transcription factors and showed how these membrane-bound molecules control the synthesis of cholesterol and fatty acids through a newly described process of Regulated Intramembrane Proteolysis. For this work, Drs. Brown and Goldstein received the Albany Medical Center Prize in Medicine and Biomedical Research (2003). Dr. Goldstein is currently Chairman of the Albert Lasker Medical Research Awards Jury and is a member of the Boards of Trustees of the Howard Hughes Medical Institute and The Rockefeller University.
• Francisco Gonzalez Cigarroa, (M.D. 1983), president of the University of Texas Health Science Center at San Antonio, chancellor of the University of Texas System, chief of pediatric transplant surgery at the University of Texas Health Science Center at San Antonio.
• Norman M. Kaplan (M.D. 1955?) UTSW Clinical Professor of Medicine, author, lecturer, recipient American Heart Association lifetime achievement award
• Malcolm Perry, (M.D. 1955) (deceased 2009) while a surgery resident attended to John F. Kennedy at Parkland Memorial Hospital on November 22, 1963, chief of vascular surgery New York-Cornell Hospital 1978 to 1988, professor of surgery Texas Tech University, professor emeritus UTSW.
• Stuart Spitzer (M.D. 1971?), incoming Republican member of the Texas House of Representatives from District 4
• Richard Warshak, (Ph.D. 1979) clinical and research psychologist and author; known internationally for his expertise on divorce, child custody, and parental alienation; served as a White House consultant on family law reform; 2008 Distinguished Alumni Award
• Xiaodong Wang (Ph.D.), biomedical researcher, member of the National Academy of Science 2004, The Shaw Prize in Life Science and Medicine 2006, Director National Institute of Biological Sciences, Beijing
• Kern Wildenthal (M.D. 1964) president of the Children's Medical Center Foundation in Dallas, President Emeritus and Professor of Medicine Emeritus UTSW, president UTSW 1986-2008.
• Jean D. Wilson (M.D. 1955), Professor of Medicine UTSW, Institute of Medicine member since 1994, co-editor Harrison's Textbook of Medicine, National Academy of Sciences member since 1983, American Academy of Arts and Sciences member since 1982.

Affiliated health care institutions

Major affiliations:

• Parkland Memorial Hospital – The primary teaching institution of UT Southwestern, whose faculty is responsible for caring for all of the hospital’s patients, this 2.1 million-square-foot acute care facility has 862 single-patient rooms and is one of the busiest public hospitals in the nation, with more than 1 million patient visits each year.
• Children’s Medical Center Dallas – The primary pediatric teaching hospital for UT Southwestern, this hospital is licensed for 490 beds, has more than 50 pediatric specialty programs, and is the only pediatric hospital in North Texas with a designated Level 1 trauma center.
• Zale Lipshy University Hospital – A 148-bed specialty hospital, this facility is a dedicated neurological treatment center and a Joint Commission-certified advanced comprehensive stroke center.
• William P. Clements Jr. University Hospital – Opened in December 2014, UT Southwestern’s signature 12-floor, 460-bed hospital was designed as a physical embodiment of UTSW’s threefold mission of providing medical education, research, and patient care. The facility’s 1.3 million square feet includes 72 adult ICU rooms, 40 emergency treatment rooms, 30 neonatal ICU rooms, 16 labor and delivery rooms, 24 surgical suites, 12 interventional suites, six endoscopy suites, six X-ray suites, four CT scans, three obstetrics specialty surgical suites, two MRIs, and two nuclear medicine rooms.
• Dallas Veteran Affairs Medical Center – The U.S. Department of Veterans Affairs’ second largest health care system, the Dallas VA Medical Center serves 38 Texas counties and two counties in southern Oklahoma, providing primary, tertiary, and long-term care. The 822-bed system has a Spinal Cord Injury Center, Domiciliary Care Program, and Community Living Center with a dedicated hospice unit.
• Texas Health Presbyterian Hospital Dallas – Part of the Texas Health Resources (THR) system, this 888-bed, acute-care facility was the first hospital in Dallas to receive Cycle IV Chest Pain accreditation from the Society of Cardiovascular Patient Care, and it is also accredited for emergency stroke care by The Joint Commission. In 2016, UT Southwestern and THR launched a clinically integrated health care network called Southwestern Health Resources to provide increased access to primary and specialized care to North Texas residents, from preventive measures to advanced interventions.

Minor affiliations:

References

External links

• UT Southwestern Medical Center website
• UTSW MSTP Website
• The Immunology Database and Analysis Portal – an NIAID-funded database resource of reference and experiment data covering the entire immunology domain
• Influenza Research Database – Database of influenza genomic sequences and related information.
• Virus Pathogen Resource – Virus Pathogen Resource.