USP8

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1WHB, 2A9U, 2GFO, 2GWF, 3N3K

Identifiers

Aliases

USP8, HumORF8, SPG59, UBPY, ubiquitin specific peptidase 8

External IDs

MGI: 1934029 HomoloGene: 3782 GeneCards: USP8

Gene location (Human)

Chr.	Chromosome 15 (human)^[1]

Band	No data available	Start	50,424,380 bp^[1]
Band	No data available	End	50,514,419 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	No data available	Start	126,707,328 bp^[2]
Band	No data available	End	126,759,297 bp^[2]

Gene ontology
Molecular function	• cysteine-type peptidase activity • SH3 domain binding • thiol-dependent ubiquitinyl hydrolase activity • peptidase activity • protein binding • thiol-dependent ubiquitin-specific protease activity • cysteine-type endopeptidase activity • hydrolase activity • cadherin binding
Cellular component	• cytoplasm • cytosol • endosome • membrane • plasma membrane • extrinsic component of endosome membrane • midbody • early endosome • endosome membrane • extrinsic component of plasma membrane • nucleus • postsynaptic density of dendrite • dendritic spine
Biological process	• protein K48-linked deubiquitination • ubiquitin-dependent protein catabolic process • mitotic cytokinesis • endosome organization • proteolysis • protein K63-linked deubiquitination • cell cycle • cell proliferation • protein deubiquitination
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9101


84092

Ensembl


ENSG00000138592


ENSMUSG00000027363

UniProt


P40818


Q80U87

RefSeq (mRNA)


NM_001128610 NM_001128611 NM_001283049 NM_005154


NM_001252580 NM_019729

RefSeq (protein)


NP_001122082 NP_001269978 NP_005145


NP_001239509 NP_062703

Location (UCSC)

Chr 15: 50.42 – 50.51 Mb

Chr 15: 126.71 – 126.76 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Ubiquitin carboxyl-terminal hydrolase 8 is an enzyme that in humans is encoded by the USP8 gene.^[5]^[6]^[7]

Interactions

USP8 has been shown to interact with RNF41^[8] and STAM2.^[9]^[10]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000138592 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027363 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (July 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. PMID 12838346. doi:10.1038/nrg1111.
↑ Janssen JW, Schleithoff L, Bartram CR, Schulz AS (May 1998). "An oncogenic fusion product of the phosphatidylinositol 3-kinase p85beta subunit and HUMORF8, a putative deubiquitinating enzyme". Oncogene. 16 (13): 1767–72. PMID 9582025. doi:10.1038/sj.onc.1201695.
↑ "Entrez Gene: USP8 ubiquitin specific peptidase 8".
↑ Wu, Xiuli; Yen Lily; Irwin Lisa; Sweeney Colleen; Carraway Kermit L (September 2004). "Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8". Mol. Cell. Biol. United States. 24 (17): 7748–57. ISSN 0270-7306. PMC 506982 . PMID 15314180. doi:10.1128/MCB.24.17.7748-7757.2004.
↑ Kaneko, Tomonori; Kumasaka Takashi; Ganbe Tadashi; Sato Takao; Miyazawa Keiji; Kitamura Naomi; Tanaka Nobuo (November 2003). "Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain". J. Biol. Chem. United States. 278 (48): 48162–8. ISSN 0021-9258. PMID 13129930. doi:10.1074/jbc.M306677200.
↑ Kato, M; Miyazawa K; Kitamura N (December 2000). "A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP". J. Biol. Chem. UNITED STATES. 275 (48): 37481–7. ISSN 0021-9258. PMID 10982817. doi:10.1074/jbc.M007251200.

D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators.". Crit. Rev. Biochem. Mol. Biol. 33 (5): 337–52. PMID 9827704. doi:10.1080/10409239891204251.
Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 1 (5): 223–9. PMID 7584044. doi:10.1093/dnares/1.5.223.
Naviglio S, Mattecucci C, Matoskova B, et al. (1998). "UBPY: a growth-regulated human ubiquitin isopeptidase.". EMBO J. 17 (12): 3241–50. PMC 1170662 . PMID 9628861. doi:10.1093/emboj/17.12.3241.
Kato M, Miyazawa K, Kitamura N (2001). "A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP.". J. Biol. Chem. 275 (48): 37481–7. PMID 10982817. doi:10.1074/jbc.M007251200.
Gnesutta N, Ceriani M, Innocenti M, et al. (2001). "Cloning and characterization of mouse UBPy, a deubiquitinating enzyme that interacts with the ras guanine nucleotide exchange factor CDC25(Mm)/Ras-GRF1.". J. Biol. Chem. 276 (42): 39448–54. PMID 11500497. doi:10.1074/jbc.M103454200.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Kaneko T, Kumasaka T, Ganbe T, et al. (2004). "Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain.". J. Biol. Chem. 278 (48): 48162–8. PMID 13129930. doi:10.1074/jbc.M306677200.
Soares L, Seroogy C, Skrenta H, et al. (2004). "Two isoforms of otubain 1 regulate T cell anergy via GRAIL.". Nat. Immunol. 5 (1): 45–54. PMID 14661020. doi:10.1038/ni1017.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Wu X, Yen L, Irwin L, et al. (2004). "Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8.". Mol. Cell. Biol. 24 (17): 7748–57. PMC 506982 . PMID 15314180. doi:10.1128/MCB.24.17.7748-7757.2004.
Berruti G, Martegani E (2005). "The deubiquitinating enzyme mUBPy interacts with the sperm-specific molecular chaperone MSJ-1: the relation with the proteasome, acrosome, and centrosome in mouse male germ cells.". Biol. Reprod. 72 (1): 14–21. PMID 15342353. doi:10.1095/biolreprod.104.030866.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.". Mol. Cell Proteomics. 4 (6): 785–95. PMID 15778465. doi:10.1074/mcp.M500021-MCP200.
Row PE, Prior IA, McCullough J, et al. (2006). "The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation.". J. Biol. Chem. 281 (18): 12618–24. PMID 16520378. doi:10.1074/jbc.M512615200.
Mizuno E, Kobayashi K, Yamamoto A, et al. (2006). "A deubiquitinating enzyme UBPY regulates the level of protein ubiquitination on endosomes.". Traffic. 7 (8): 1017–31. PMID 16771824. doi:10.1111/j.1600-0854.2006.00452.x.
Avvakumov GV, Walker JR, Xue S, et al. (2007). "Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8).". J. Biol. Chem. 281 (49): 38061–70. PMID 17035239. doi:10.1074/jbc.M606704200.

PDB gallery

1whb: Solution structure of the Rhodanese-like domain in human ubiquitin specific protease 8 (UBP8)

2a9u: Structure of the N-terminal domain of Human Ubiquitin carboxyl-terminal hydrolase 8 (USP8)

2gfo: Structure of the Catalytic Domain of Human Ubiquitin Carboxyl-terminal Hydrolase 8

2gwf: Structure of a USP8-NRDP1 complex

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USP8

Interactions

References

Further reading