UQCRC1

Identifiers

UQCRC1, D3S3191, QCR1, UQCR1, ubiquinol-cytochrome c reductase core protein I

External IDs

MGI: 107876 HomoloGene: 2525 GeneCards: UQCRC1

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	No data available	Start	48,599,002 bp^[1]
Band	No data available	End	48,610,976 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	No data available	Start	108,936,633 bp^[2]
Band	No data available	End	108,949,623 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• ubiquinol-cytochrome-c reductase activity • protein complex binding • zinc ion binding • metal ion binding • catalytic activity • metalloendopeptidase activity • ubiquitin protein ligase binding • protein binding
Cellular component	• mitochondrial respiratory chain complex III • membrane • myelin sheath • mitochondrion • mitochondrial respiratory chain • mitochondrial inner membrane • respiratory chain • cytosol
Biological process	• protein processing • response to activity • aerobic respiration • oxidative phosphorylation • response to alkaloid • oxidation-reduction process • mitochondrial electron transport, ubiquinol to cytochrome c • hydrogen ion transmembrane transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


7384


22273

Ensembl


ENSG00000010256


n/a

UniProt


P31930


Q9CZ13

RefSeq (mRNA)


NM_003365


NM_025407

RefSeq (protein)


NP_003356


NP_079683

Location (UCSC)

Chr 3: 48.6 – 48.61 Mb

Chr 3: 108.94 – 108.95 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Cytochrome b-c1 complex subunit 1, mitochondrial is a protein that in humans is encoded by the UQCRC1 gene.^[5]^[6]

Its gene product is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase (UQCR, Complex III or Cytochrome bc1 complex), which consists of the products of one mitochondrially encoded gene, MTCYTB (mitochondrial cytochrome b) and ten nuclear genes: UQCRC1, UQCRC2, Cytochrome c1, UQCRFS1 (Rieske protein), UQCRB, "11kDa protein", UQCRH (cyt c1 Hinge protein), Rieske Protein presequence, "cyt. c1 associated protein", and Rieske-associated protein.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000010256 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: n/a - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Hoffman GG, Lee S, Christiano AM, Chung-Honet LC, Cheng W, Katchman S, Uitto J, Greenspan DS (Nov 1993). "Complete coding sequence, intron/exon organization, and chromosomal location of the gene for the core I protein of human ubiquinol-cytochrome c reductase". J Biol Chem. 268 (28): 21113–9. PMID 8407948.
↑ "Entrez Gene: UQCRC1 ubiquinol-cytochrome c reductase core protein I".

Suzuki H, Hosokawa Y, Nishikimi M, Ozawa T (1991). "Existence of common homologous elements in the transcriptional regulatory regions of human nuclear genes and mitochondrial gene for the oxidative phosphorylation system.". J. Biol. Chem. 266 (4): 2333–8. PMID 1846623.
Broger C, Nałecz MJ, Azzi A (1980). "Interaction of cytochrome c with cytochrome bc1 complex of the mitochondrial respiratory chain.". Biochim. Biophys. Acta. 592 (3): 519–27. PMID 6251869. doi:10.1016/0005-2728(80)90096-1.
Islam MM, Tanaka M, Suzuki H, et al. (1994). "A complete cDNA sequence for core I protein subunit of human ubiquinol-cytochrome c reductase". Biochem. Mol. Biol. Int. 33 (2): 410. PMID 7951059.
Islam MM, Tanaka M, Suzuki H, et al. (1995). "A complete cDNA sequence for core I protein subunit of human ubiquinol-cytochrome c reductase". Biochem. Mol. Biol. Int. 33 (4): 815. PMID 7981668.
Islam MM, Tanaka M, Suzuki H, et al. (1994). "A complete cDNA sequence for core I protein subunit of human ubiquinol-cytochrome c reductase". Biochem. Mol. Biol. Int. 32 (5): 797–805. PMID 8069229.
Hughes GJ, Frutiger S, Paquet N, et al. (1994). "Human liver protein map: update 1993". Electrophoresis. 14 (11): 1216–22. PMID 8313870. doi:10.1002/elps.11501401181.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. PMID 8889549. doi:10.1101/gr.6.9.807.
Valnot I, Kassis J, Chretien D, et al. (1999). "A mitochondrial cytochrome b mutation but no mutations of nuclearly encoded subunits in ubiquinol cytochrome c reductase (complex III) deficiency". Hum. Genet. 104 (6): 460–6. PMID 10453733. doi:10.1007/s004390050988.
Hu WH, Hausmann ON, Yan MS, et al. (2002). "Identification and characterization of a novel Nogo-interacting mitochondrial protein (NIMP)". J. Neurochem. 81 (1): 36–45. PMID 12067236. doi:10.1046/j.1471-4159.2002.00788.x.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Aboulaich N, Vainonen JP, Strålfors P, Vener AV (2005). "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes". Biochem. J. 383 (Pt 2): 237–48. PMC 1134064 . PMID 15242332. doi:10.1042/BJ20040647.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Wen JJ, Garg N (2005). "Oxidative modification of mitochondrial respiratory complexes in response to the stress of Trypanosoma cruzi infection". Free Radic. Biol. Med. 37 (12): 2072–81. PMID 15544925. doi:10.1016/j.freeradbiomed.2004.09.011.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209.
Kulawiec M, Arnouk H, Desouki MM, et al. (2007). "Proteomic analysis of mitochondria-to-nucleus retrograde response in human cancer". Cancer Biol. Ther. 5 (8): 967–75. PMID 16775426. doi:10.4161/cbt.5.8.2880.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. PMC 1847948 . PMID 17353931. doi:10.1038/msb4100134.

PDB gallery

1be3: CYTOCHROME BC1 COMPLEX FROM BOVINE

1bgy: CYTOCHROME BC1 COMPLEX FROM BOVINE

1l0l: structure of bovine mitochondrial cytochrome bc1 complex with a bound fungicide famoxadone

1l0n: native structure of bovine mitochondrial cytochrome bc1 complex

1ntk: Crystal Structure of Mitochondrial Cytochrome bc1 in Complex with Antimycin A1

1ntm: Crystal Structure of Mitochondrial Cytochrome bc1 Complex at 2.4 Angstrom

1ntz: Crystal Structure of Mitochondrial Cytochrome bc1 Complex Bound with Ubiquinone

1nu1: Crystal Structure of Mitochondrial Cytochrome bc1 Complexed with 2-nonyl-4-hydroxyquinoline N-oxide (NQNO)

1pp9: Bovine cytochrome bc1 complex with stigmatellin bound

1ppj: Bovine cytochrome bc1 complex with stigmatellin and antimycin

1qcr: CRYSTAL STRUCTURE OF BOVINE MITOCHONDRIAL CYTOCHROME BC1 COMPLEX, ALPHA CARBON ATOMS ONLY

1sqq: Crystal Structure Analysis of Bovine Bc1 with Methoxy Acrylate Stilbene (MOAS)

1sqv: Crystal Structure Analysis of Bovine Bc1 with UHDBT

1sqx: Crystal Structure Analysis of Bovine Bc1 with Stigmatellin A

2a06: Bovine cytochrome bc1 complex with stigmatellin bound

2fyu: Crystal structure of bovine heart mitochondrial bc1 with jg144 inhibitor

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UQCRC1

References

Further reading