UNC45A

UNC45A

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2DBA

Identifiers

UNC45A, GC-UNC45, GCUNC-45, GCUNC45, IRO039700, SMAP-1, SMAP1, UNC-45A, unc-45 myosin chaperone A

External IDs

MGI: 2142246 HomoloGene: 32423 GeneCards: UNC45A

Gene location (Human)

Chr.	Chromosome 15 (human)^[1]

Band	No data available	Start	90,930,180 bp^[1]
Band	No data available	End	90,954,093 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	No data available	Start	80,325,292 bp^[2]
Band	No data available	End	80,341,005 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• Hsp90 protein binding • protein binding • cadherin binding
Cellular component	• cytoplasm • perinuclear region of cytoplasm • nucleus • Golgi apparatus • cytosol • nuclear speck
Biological process	• multicellular organism development • cell differentiation • muscle organ development • chaperone-mediated protein folding
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


55898


101869


ENSG00000140553


ENSMUSG00000030533


Q9H3U1


Q99KD5

RefSeq (mRNA)

NM_001039675 NM_017979 NM_018671 NM_001323619 NM_001323620
NM_001323621


NM_133952

RefSeq (protein)


NP_001034764 NP_001310548 NP_001310549 NP_001310550 NP_061141


NP_598713

Location (UCSC)

Chr 15: 90.93 – 90.95 Mb

Chr 15: 80.33 – 80.34 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Protein unc-45 homolog A is a protein that in humans is encoded by the UNC45A gene.^[5]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000140553 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030533 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Price MG, Landsverk ML, Barral JM, Epstein HF (Oct 2002). "Two mammalian UNC-45 isoforms are related to distinct cytoskeletal and muscle-specific functions". J Cell Sci. 115 (Pt 21): 4013–23. PMID 12356907. doi:10.1242/jcs.00108.
↑ "Entrez Gene: UNC45A unc-45 homolog A (C. elegans)".

Further reading

Bazzaro M, Santillan A, Lin Z, et al. (2008). "Myosin II Co-Chaperone General Cell UNC-45 Overexpression Is Associated with Ovarian Cancer, Rapid Proliferation, and Motility". Am. J. Pathol. 171 (5): 1640–9. PMC 2043524 . PMID 17872978. doi:10.2353/ajpath.2007.070325.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. PMC 1847948 . PMID 17353931. doi:10.1038/msb4100134.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. PMID 17081983. doi:10.1016/j.cell.2006.09.026.
Chadli A, Graham JD, Abel MG, et al. (2006). "GCUNC-45 Is a Novel Regulator for the Progesterone Receptor/hsp90 Chaperoning Pathway". Mol. Cell. Biol. 26 (5): 1722–30. PMC 1430258 . PMID 16478993. doi:10.1128/MCB.26.5.1722-1730.2006.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. PMC 442148 . PMID 15231748. doi:10.1101/gr.2334104.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.

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