ULK2

unc-51-like kinase 2 (C. elegans)
Identifiers
Symbol ULK2
Entrez 9706
HUGO 13480
OMIM 608650
RefSeq NM_014683
UniProt Q8IYT8
Other data
EC number 2.7.11.1
Locus Chr. 17 p11.2

Unc-51-like kinase 2 (C. elegans) also known as ULK2 is an enzyme which in humans is encoded by the ULK2 gene.[1] The gene is located within the Smith-Magenis syndrome region on chromosome 17.

Structure and function

This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain.[2] ULK2 and the GTPase activating protein SynGAP function cooperatively in axon formation.[3]

References

  1. ↑ Yan J, Kuroyanagi H, Tomemori T, Okazaki N, Asato K, Matsuda Y, Suzuki Y, Ohshima Y, Mitani S, Masuho Y, Shirasawa T, Muramatsu M (October 1999). "Mouse ULK2, a novel member of the UNC-51-like protein kinases: unique features of functional domains". Oncogene. 18 (43): 5850–9. PMID 10557072. doi:10.1038/sj.onc.1202988.
  2. ↑ "Entrez Gene: ULK2".
  3. ↑ Tomoda T, Kim JH, Zhan C, Hatten ME (March 2004). "Role of Unc51.1 and its binding partners in CNS axon outgrowth". Genes Dev. 18 (5): 541–58. PMC 374236 Freely accessible. PMID 15014045. doi:10.1101/gad.1151204.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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