UIMC1

UIMC1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2MKF, 2MKG, 2RR9, 2N9E

Identifiers

UIMC1, RAP80, X2HRIP110, ubiquitin interaction motif containing 1

External IDs

MGI: 103185 HomoloGene: 9455 GeneCards: UIMC1

Gene location (Human)

Chr.	Chromosome 5 (human)^[1]

Band	No data available	Start	176,905,005 bp^[1]
Band	No data available	End	177,022,633 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 13 (mouse)^[2]

Band	No data available	Start	55,027,880 bp^[2]
Band	No data available	End	55,100,300 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• histone binding • K63-linked polyubiquitin modification-dependent protein binding • protein binding
Cellular component	• BRCA1-A complex • nucleus • nucleoplasm • nuclear body
Biological process	• response to ionizing radiation • positive regulation of DNA repair • histone H2A K63-linked deubiquitination • negative regulation of transcription, DNA-templated • double-strand break repair via nonhomologous end joining • regulation of transcription, DNA-templated • G2 DNA damage checkpoint • transcription, DNA-templated • cellular response to DNA damage stimulus • covalent chromatin modification • double-strand break repair • DNA repair • protein deubiquitination
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


51720


20184


ENSG00000087206


ENSMUSG00000025878


Q96RL1


Q5U5Q9

RefSeq (mRNA)


NM_001199297 NM_001199298 NM_016290 NM_001317961


NM_001293660 NM_011307

RefSeq (protein)


NP_001186226 NP_001186227 NP_001304890 NP_057374


NP_001280589 NP_035437

Location (UCSC)

Chr 5: 176.91 – 177.02 Mb

Chr 5: 55.03 – 55.1 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

BRCA1-A complex subunit RAP80 is a protein that in humans is encoded by the UIMC1 gene.^[5]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000087206 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025878 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Yan Z, Kim YS, Jetten AM (Aug 2002). "RAP80, a novel nuclear protein that interacts with the retinoid-related testis-associated receptor". J Biol Chem. 277 (35): 32379–88. PMID 12080054. doi:10.1074/jbc.M203475200.
↑ "Entrez Gene: UIMC1 ubiquitin interaction motif containing 1".

Further reading

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Kim YS, Nakanishi G, Oudes AJ, et al. (2004). "Tsp57: a novel gene induced during a specific stage of spermatogenesis.". Biol. Reprod. 70 (1): 106–13. PMID 12954732. doi:10.1095/biolreprod.103.018465.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. PMC 442148 . PMID 15231748. doi:10.1101/gr.2334104.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. PMC 514446 . PMID 15302935. doi:10.1073/pnas.0404720101.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell. 127 (3): 635–48. PMID 17081983. doi:10.1016/j.cell.2006.09.026.
Wang B, Matsuoka S, Ballif BA, et al. (2007). "Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response.". Science. 316 (5828): 1194–8. PMC 3573690 . PMID 17525340. doi:10.1126/science.1139476.
Sobhian B, Shao G, Lilli DR, et al. (2007). "RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites.". Science. 316 (5828): 1198–202. PMC 2706583 . PMID 17525341. doi:10.1126/science.1139516.
Kim H, Chen J, Yu X (2007). "Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response.". Science. 316 (5828): 1202–5. PMID 17525342. doi:10.1126/science.1139621.
Shebzukhov YV, Koroleva EP, Khlgatian SV, et al. (2007). "RAP80/UIMC1 as cancer-associated antigen: alternative splice variants and their immunogenicity.". Cancer Lett. 255 (2): 255–62. PMID 17562356. doi:10.1016/j.canlet.2007.04.013.
Yan J, Kim YS, Yang XP, et al. (2007). "The ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response.". Cancer Res. 67 (14): 6647–56. PMC 2391092 . PMID 17621610. doi:10.1158/0008-5472.CAN-07-0924.
Yan J, Yang XP, Kim YS, et al. (2007). "RAP80 interacts with the SUMO-conjugating enzyme UBC9 and is a novel target for sumoylation.". Biochem. Biophys. Res. Commun. 362 (1): 132–8. PMC 2049087 . PMID 17698038. doi:10.1016/j.bbrc.2007.07.158.

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