U-89843A

U-89843A

Legal status
Legal status	In general: legal
Identifiers
IUPAC name 6,7-dimethyl-2,4-dipyrrolidin-1-yl-7H-pyrrolo[2,3-d]pyrimidine
CAS Number	157013-32-6 Y
PubChem CID	154689
ChemSpider	136273
Chemical and physical data
Formula	C16H23N5
Molar mass	285.387 g/mol
3D model (JSmol)	Interactive image
SMILES CC1=CC2=C(N1C)N=C(N=C2N3CCCC3)N4CCCC4
InChI InChI=1S/C16H23N5/c1-12-11-13-14(19(12)2)17-16(21-9-5-6-10-21)18-15(13)20-7-3-4-8-20/h11H,3-10H2,1-2H3 Key:UADIKEUOAMACNA-UHFFFAOYSA-N
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U-89843A (PNU-89843) is a sedative drug which acts as an agonist at GABA_A receptors, specifically acting as a positive allosteric modulator selective for the α1, α3 and α6 subtypes.^[1] It has sedative effects in animals but without causing ataxia, and also acts as an antioxidant and may have neuroprotective effects.^[2] It was developed by a team at Upjohn in the 1990s.^[3]

References

1. ↑ Im, HK; Im, WB; Pregenzer, JF; Carter, DB; Hamilton, BJ (1995). "U-89843A is a novel allosteric modulator of gamma-aminobutyric acidA receptors". The Journal of Pharmacology and Experimental Therapeutics. 275 (3): 1390–5. PMID 8531107. 
2. ↑ Bundy, GL; Ayer, DE; Banitt, LS; Belonga, KL; Mizsak, SA; Palmer, JR; Tustin, JM; Chin, JE; et al. (1995). "Synthesis of novel 2,4-diaminopyrrolo-2,3-dpyrimidines with antioxidant, neuroprotective, and antiasthma activity". Journal of Medicinal Chemistry. 38 (21): 4161–3. PMID 7473542. doi:10.1021/jm00021a004. 
3. ↑ US Patent 5502187 Pharmaceutically active bicyclic-heterocyclic amines