Tweety family member 2
Tweety family member 2 is a protein that in humans is encoded by the TTYH2 gene.
[5]
Function
This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-activated large conductance chloride(-) channel, and may play a role in kidney tumorigenesis. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
References
Further reading
- Bisson, N.; James, D. A.; Ivosev, G.; Tate, S. A.; Bonner, R.; Taylor, L.; Pawson, T. (2011). "Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor". Nature Biotechnology. 29 (7): 653–658. PMID 21706016. doi:10.1038/nbt.1905.
- Ibarrola, N; Molina, H; Iwahori, A; Pandey, A (2004). "A novel proteomic approach for specific identification of tyrosine kinase substrates using 13Ctyrosine". Journal of Biological Chemistry. 279 (16): 15805–13. PMID 14739304. doi:10.1074/jbc.M311714200.
- Rae, F. K.; Hooper, J. D.; Eyre, H. J.; Sutherland, G. R.; Nicol, D. L.; Clements, J. A. (2001). "TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is located on 17q24 and upregulated in renal cell carcinoma". Genomics. 77 (3): 200–7. PMID 11597145. doi:10.1006/geno.2001.6629.
- Toiyama, Y; Mizoguchi, A; Kimura, K; Hiro, J; Inoue, Y; Tutumi, T; Miki, C; Kusunoki, M (2007). "TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is up-regulated in colon carcinoma and involved in cell proliferation and cell aggregation". World journal of gastroenterology : WJG. 13 (19): 2717–21. PMC 4147121
. PMID 17569141.
- Suzuki, M; Mizuno, A (2004). "A novel human Cl(-) channel family related to Drosophila flightless locus". Journal of Biological Chemistry. 279 (21): 22461–8. PMID 15010458. doi:10.1074/jbc.M313813200.
- He, Y; Ramsay, A. J.; Hunt, M. L.; Whitbread, A. K.; Myers, S. A.; Hooper, J. D. (2008). "N-glycosylation analysis of the human Tweety family of putative chloride ion channels supports a penta-spanning membrane arrangement: Impact of N-glycosylation on cellular processing of Tweety homologue 2 (TTYH2)". Biochemical Journal. 412 (1): 45–55. PMID 18260827. doi:10.1042/BJ20071722.
- He, Y; Hryciw, D. H.; Carroll, M. L.; Myers, S. A.; Whitbread, A. K.; Kumar, S; Poronnik, P; Hooper, J. D. (2008). "The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels". Journal of Biological Chemistry. 283 (35): 24000–10. PMC 3259790 . PMID 18577513. doi:10.1074/jbc.M803361200.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
