Tumor-associated macrophage

Tumor-associated macrophages (TAMs) are a type of cell belonging to the macrophage lineage. They are found in close proximity or within tumor masses.[1][2] TAMs are derived from circulating monocytes or resident tissue macrophages, which form the major leukocytic infiltrate found within the stroma of many tumor types. The function of TAMs is controversial as there is growing evidence for their involvement in both pro-tumor (e.g. promotion of growth and metastasis through tumor angiogenesis) as well as anti-tumor (tumoricidal and tumorostatic) processes.[1][3][4] TAMs interact with a wide range of growth factors, cytokines and chemokines in the tumor microenvironment which is thought to educate the TAMs and determine their specific phenotype and hence functional role as the microenvironment varies between different types of tumors. TAMs have therefore been shown to differ in their roles depending on the type of tumor with which they are associated.[5] In many tumor types TAM infiltration level has been shown to be of significant prognostic value. TAMs have been linked to poor prognosis in breast cancer, ovarian cancer, types of glioma and lymphoma; better prognosis in colon and stomach cancers and both poor and better prognoses in lung and prostate cancers.[6]

Macrophages that infiltrate metastatic sites have specific characteristics and are known as metastasis-associated macrophages (MAMs).[7]

References

  1. 1 2 Birbrair, Alexander; Zhang, Tan; Wang, Zhong-Min; Messi, Maria Laura; Olson, John D.; Mintz, Akiva; Delbono, Osvaldo (2014-07-01). "Type-2 pericytes participate in normal and tumoral angiogenesis". American Journal of Physiology. Cell Physiology. 307 (1): C25–C38. ISSN 0363-6143. PMC 4080181 Freely accessible. PMID 24788248. doi:10.1152/ajpcell.00084.2014.
  2. ↑ Shih, J-Y., Yuan, A., Chen, J.J.-W., Yang, P-C. (2006). Tumor-Associated Macrophage: Its Role in Cancer Invasion and Metastasis. Journal of Cancer Molecules 2(3): 101-106
  3. ↑ Bingle, L.; Brown, N. J.; Lewis, C. E. (2002). "The role of tumour-associated macrophages in tumour progression: Implications for new anticancer therapies". The Journal of Pathology. 196 (3): 254–265. PMID 11857487. doi:10.1002/path.1027.
  4. ↑ Thoreau, M; Leong Penny, H; Tan, KW; Regnier, F; Weiss, JM; Trautmann, A; Bercovici, N (2015) Vaccine-induced tumor regression requires a dynamic cooperation between T cells and myeloid cells at the tumor site
  5. ↑ Lewis, C. E.; Pollard, J. W. (2006). "Distinct Role of Macrophages in Different Tumor Microenvironments". Cancer Research. 66 (2): 605–612. PMID 16423985. doi:10.1158/0008-5472.CAN-05-4005.
  6. ↑ Allavena, P.; Sica, A.; Solinas, G.; Porta, C.; Mantovani, A. (2008). "The inflammatory micro-environment in tumor progression: The role of tumor-associated macrophages". Critical Reviews in Oncology/Hematology. 66: 1. doi:10.1016/j.critrevonc.2007.07.004.
  7. ↑ Gabrilovich, Dmitry (29 June 2015). "Fatal attraction: How macrophages participate in tumor metastases". The Journal of Experimental Medicine. 212 (7): 976–976. PMC 4493407 Freely accessible. PMID 26122939. doi:10.1084/jem.2127insight1.


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