Treponema denticola
| Treponema denticola | |
|---|---|
Scientific classification  | |
| Domain: | Bacteria |
| Phylum: | Spirochaetes |
| Order: | Spirochaetales |
| Family: | Spirochaetaceae |
| Genus: | Treponema |
| Species: | T. denticola |
| Binomial name | |
| Treponema denticola | |
Treponema denticola is a Gram-negative, obligate anaerobic, motile and highly proteolytic spirochete bacterium. It dwells in a complex and diverse microbial community within the oral cavity and is highly specialized to survive in this environment. T. denticola is associated with the incidence and severity of human periodontal disease. Having elevated T. denticola levels in the mouth is considered one of the main etiological agents of periodontitis.[1] T. denticola is related to the syphilis-causing obligate human pathogen, Treponema pallidum subsp. pallidum. It has also been isolated from women with bacterial vaginosis.[2]
Genome
The first genome of T. denticola to be sequenced was strain 35405 which was initially isolated and designated as the type strain by Chan et al.[3] The 2,843,201-bp genome sequence encodes 2,786 open reading frames (ORFs) as well a 6 rRNAs and 44 tRNAs. This is in stark contrast to the minimal genome of Treponema pallidum which encodes only 1,040 ORFs.[4]
See also
References
- ↑ Marie-Claude Jobin, Mohsen Amin, Richard P. Ellen (2008). "Chapter 8 - The Molecular Biology of the Survival and Virulence of Treponema denticola". In Anthony H. Rogers. Molecular Oral Microbiology. Caister Academic Press. p. 177. ISBN 978-1-904455-24-0.
- ↑ Africa, Charlene; Nel, Janske; Stemmet, Megan (2014). "Anaerobes and Bacterial Vaginosis in Pregnancy: Virulence Factors Contributing to Vaginal Colonisation". International Journal of Environmental Research and Public Health. 11 (7): 6979–7000. ISSN 1660-4601. PMC 4113856
. PMID 25014248. doi:10.3390/ijerph110706979. - ↑ Chan, E. C.; Siboo, R.; Keng, T.; Psarra, N.; Hurley, R.; Cheng, S. L.; Iugovaz, I. (April 1993). "Treponema denticola (ex Brumpt 1925) sp. nov., nom. rev., and identification of new spirochete isolates from periodontal pockets". International Journal of Systematic Bacteriology. 43 (2): 196–203. ISSN 0020-7713. PMID 8494734. doi:10.1099/00207713-43-2-196.
- ↑ Seshadri, Rekha; Myers, Garry S. A.; Tettelin, Hervé; Eisen, Jonathan A.; Heidelberg, John F.; Dodson, Robert J.; Davidsen, Tanja M.; DeBoy, Robert T.; Fouts, Derrick E. (2004-04-13). "Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes". Proceedings of the National Academy of Sciences of the United States of America. 101 (15): 5646–5651. ISSN 0027-8424. PMC 397461 . PMID 15064399. doi:10.1073/pnas.0307639101.