Transcription elongation regulator 1

TCERG1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2DK7, 2DOD, 2DOE, 2DOF, 2E71, 2KIQ, 2KIS, 2MW9, 2MWA, 2MWB, 2MWD, 2MWF, 2NNT, 3HFH, 3Q1I, 4FQG, 2N4R, 2N4S, 2N4T, 2N4U, 2N4V, 2N4W

Identifiers

Aliases

TCERG1, CA150, TAF2S, Urn1, transcription elongation regulator 1

External IDs

MGI: 1926421 HomoloGene: 4879 GeneCards: TCERG1

Gene location (Human)

Chr.	Chromosome 5 (human)^[1]

Band	No data available	Start	146,447,311 bp^[1]
Band	No data available	End	146,511,961 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 18 (mouse)^[2]

Band	No data available	Start	42,511,510 bp^[2]
Band	No data available	End	42,575,551 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• transcription coactivator activity • RNA polymerase II transcription corepressor activity • proline-rich region binding • protein binding • RNA polymerase II repressing transcription factor binding • RNA binding
Cellular component	• nucleus • nucleoplasm
Biological process	• regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • transcription, DNA-templated
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


10915


56070

Ensembl


ENSG00000113649


ENSMUSG00000024498

UniProt


O14776


Q8CGF7

RefSeq (mRNA)


NM_001040006 NM_006706


NM_001039474 NM_001289526

RefSeq (protein)


NP_001035095 NP_006697


NP_001034563 NP_001276455

Location (UCSC)

Chr 5: 146.45 – 146.51 Mb

Chr 5: 42.51 – 42.58 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Transcription elongation regulator 1, also known as TCERG1, is a protein which in humans is encoded by the TCERG1 gene.^[5]^[6]^[7]

Function

This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms.^[5]

Interactions

Transcription elongation regulator 1 has been shown to interact with SF1^[8] and POLR2A.^[9]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000113649 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024498 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
1 2 "Entrez Gene: TCERG1 transcription elongation regulator 1".
↑ Suñé C, Hayashi T, Liu Y, Lane WS, Young RA, Garcia-Blanco MA (October 1997). "CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription". Molecular and Cellular Biology. 17 (10): 6029–39. PMC 232452 . PMID 9315662.
↑ Bohne J, Cole SE, Suñe C, Lindman BR, Ko VD, Vogt TF, Garcia-Blanco MA (October 2000). "Expression analysis and mapping of the mouse and human transcriptional regulator CA150". Mammalian Genome : Official Journal of the International Mammalian Genome Society. 11 (10): 930–3. PMID 11003711. doi:10.1007/s003350010162.
↑ Goldstrohm, A C; Albrecht T R; Suñé C; Bedford M T; Garcia-Blanco M A (November 2001). "The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1". Mol. Cell. Biol. United States. 21 (22): 7617–28. ISSN 0270-7306. PMC 99933 . PMID 11604498. doi:10.1128/MCB.21.22.7617-7628.2001.
↑ Carty, S M; Goldstrohm A C; Suñé C; Garcia-Blanco M A; Greenleaf A L (August 2000). "Protein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase II". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 97 (16): 9015–20. ISSN 0027-8424. PMC 16813 . PMID 10908677. doi:10.1073/pnas.160266597.

Suñé C, Hayashi T, Liu Y, et al. (1997). "CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription". Mol. Cell. Biol. 17 (10): 6029–39. PMC 232452 . PMID 9315662.
Neubauer G, King A, Rappsilber J, et al. (1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nat. Genet. 20 (1): 46–50. PMID 9731529. doi:10.1038/1700.
Suñé C, Garcia-Blanco MA (1999). "Transcriptional cofactor CA150 regulates RNA polymerase II elongation in a TATA-box-dependent manner". Mol. Cell. Biol. 19 (7): 4719–28. PMC 84270 . PMID 10373521.
Carty SM, Goldstrohm AC, Suñé C, et al. (2000). "Protein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase II". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 9015–20. PMC 16813 . PMID 10908677. doi:10.1073/pnas.160266597.
Bohne J, Cole SE, Suñe C, et al. (2000). "Expression analysis and mapping of the mouse and human transcriptional regulator CA150". Mamm. Genome. 11 (10): 930–3. PMID 11003711. doi:10.1007/s003350010162.
Holbert S, Denghien I, Kiechle T, et al. (2001). "The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis". Proc. Natl. Acad. Sci. U.S.A. 98 (4): 1811–6. PMC 29339 . PMID 11172033. doi:10.1073/pnas.041566798.
Goldstrohm AC, Albrecht TR, Suñé C, et al. (2001). "The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1". Mol. Cell. Biol. 21 (22): 7617–28. PMC 99933 . PMID 11604498. doi:10.1128/MCB.21.22.7617-7628.2001.
Zhou Z, Licklider LJ, Gygi SP, Reed R (2002). "Comprehensive proteomic analysis of the human spliceosome". Nature. 419 (6903): 182–5. PMID 12226669. doi:10.1038/nature01031.
Carty SM, Greenleaf AL (2003). "Hyperphosphorylated C-terminal repeat domain-associating proteins in the nuclear proteome link transcription to DNA/chromatin modification and RNA processing". Mol. Cell Proteomics. 1 (8): 598–610. PMID 12376575. doi:10.1074/mcp.M200029-MCP200.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Chattopadhyay B, Ghosh S, Gangopadhyay PK, et al. (2003). "Modulation of age at onset in Huntington's disease and spinocerebellar ataxia type 2 patients originated from eastern India". Neurosci. Lett. 345 (2): 93–6. PMID 12821179. doi:10.1016/S0304-3940(03)00436-1.
Reuter TY, Medhurst AL, Waisfisz Q, et al. (2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Exp. Cell Res. 289 (2): 211–21. PMID 14499622. doi:10.1016/S0014-4827(03)00261-1.
Palancade B, Marshall NF, Tremeau-Bravard A, et al. (2004). "Dephosphorylation of RNA polymerase II by CTD-phosphatase FCP1 is inhibited by phospho-CTD associating proteins". J. Mol. Biol. 335 (2): 415–24. PMID 14672652. doi:10.1016/j.jmb.2003.10.036.
Nagel JE, Smith RJ, Shaw L, et al. (2005). "Identification of genes differentially expressed in T cells following stimulation with the chemokines CXCL12 and CXCL10". BMC Immunol. 5: 17. PMC 514893 . PMID 15296517. doi:10.1186/1471-2172-5-17.
Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. PMID 15383276. doi:10.1016/j.molcel.2004.09.016.
Lin KT, Lu RM, Tarn WY (2004). "The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo". Mol. Cell. Biol. 24 (20): 9176–85. PMC 517884 . PMID 15456888. doi:10.1128/MCB.24.20.9176-9185.2004.
Smith MJ, Kulkarni S, Pawson T (2004). "FF domains of CA150 bind transcription and splicing factors through multiple weak interactions". Mol. Cell. Biol. 24 (21): 9274–85. PMC 522232 . PMID 15485897. doi:10.1128/MCB.24.21.9274-9285.2004.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. PMID 15635413. doi:10.1038/nature03207.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. PMC 1356129 . PMID 16344560. doi:10.1101/gr.4039406.
McFie PJ, Wang GL, Timchenko NA, et al. (2006). "Identification of a co-repressor that inhibits the transcriptional and growth-arrest activities of CCAAT/enhancer-binding protein alpha". J. Biol. Chem. 281 (26): 18069–80. PMID 16644732. doi:10.1074/jbc.M512734200.

PDB gallery

1e0l: FBP28WW DOMAIN FROM MUS MUSCULUS

2dk7: Solution structure of WW domain in transcription elongation regulator 1

2dod: Solution structure of the first FF domain of human transcription factor CA150

2doe: Solution structure of the third FF domain of human transcription factor CA150

2dof: Solution structure of the fourth FF domain of human transcription factor CA150

2nnt: General structural motifs of amyloid protofilaments

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Transcription elongation regulator 1

Function

Interactions

References

Further reading