Trans-2,3-dihydro-3-hydroxyanthranilate isomerase
Trans-2,3-dihydro-3-hydroxyanthranilate isomerase | |||||||||
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Identifiers | |||||||||
EC number | 5.3.3.17 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Trans-2,3-dihydro-3-hydroxyanthranilate isomerase (EC 5.3.3.17, phzF (gene)) is an enzyme with systematic name (5S,6S)-6-amino-5-hydroxycyclohexane-1,3-diene-1-carboxyate isomerase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- (5S,6S)-6-amino-5-hydroxycyclohexane-1,3-diene-1-carboxyate (1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate
The enzyme is involved in phenazine biosynthesis.
References
- ↑ Parsons, J.F.; Song, F.; Parsons, L.; Calabrese, K.; Eisenstein, E.; Ladner, J.E. (2004). "Structure and function of the phenazine biosynthesis protein PhzF from Pseudomonas fluorescens 2-79". Biochemistry. 43: 12427–12435. PMID 15449932. doi:10.1021/bi049059z.
- ↑ Blankenfeldt, W.; Kuzin, A.P.; Skarina, T.; Korniyenko, Y.; Tong, L.; Bayer, P.; Janning, P.; Thomashow, L.S.; Mavrodi, D.V. (2004). "Structure and function of the phenazine biosynthetic protein PhzF from Pseudomonas fluorescens". Proc. Natl. Acad. Sci. USA. 101: 16431–16436. PMC 534541 . PMID 15545603. doi:10.1073/pnas.0407371101.
- ↑ Parsons, J.F.; Calabrese, K.; Eisenstein, E.; Ladner, J.E. (2004). "Structure of the phenazine biosynthesis enzyme PhzG". Acta Crystallogr. D. 60: 2110–2113. PMID 15502343. doi:10.1107/s0907444904022474.
- ↑ Mavrodi, D.V.; Bleimling, N.; Thomashow, L.S.; Blankenfeldt, W. (2004). "The purification, crystallization and preliminary structural characterization of PhzF, a key enzyme in the phenazine-biosynthesis pathway from Pseudomonas fluorescens 2-79". Acta Crystallogr. D. 60: 184–186. PMID 14684924. doi:10.1107/s090744490302571x.
- ↑ Ahuja, E.G.; Janning, P.; Mentel, M.; Graebsch, A.; Breinbauer, R.; Hiller, W.; Costisella, B.; Thomashow, L.S.; Mavrodi, D.V.; Blankenfeldt, W. (2008). "PhzA/B catalyzes the formation of the tricycle in phenazine biosynthesis". J. Am. Chem. Soc. 130: 17053–17061. PMID 19053436. doi:10.1021/ja806325k.
External links
- Trans-2,3-dihydro-3-hydroxyanthranilate isomerase at the US National Library of Medicine Medical Subject Headings (MeSH)
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