Tissue selectivity

Tissue selectivity is a topic in distribution (pharmacology) and a property of some drugs. It refers to when a drug occurs in disproportionate concentrations and/or has disproportionate effects in specific tissues relative to other tissues.^[1] An example of such drugs are selective estrogen receptor modulators (SERM) like tamoxifen, which show estrogenic effects in some tissues and antiestrogenic effects in other tissues. Another example is peripherally-selective drugs, which do not cross the blood-brain-barrier into the central nervous system and hence are tissue-selective for the periphery.

References

↑ Zweten (5 September 1997). Antihypertensive Drugs. CRC Press. p. 345. ISBN 9789057021220. The term “tissue selectivity” is used for an agent showing varying degrees of potency between tissues, with a preferential action in a given one. |access-date= requires |url= (help)

Concepts in pharmacology
Pharmacokinetics	(L)ADME: (Liberation) Absorption Distribution Metabolism Excretion (Clearance) Loading dose Volume of distribution (Initial) Rate of infusion Compartment Bioequivalence Bioavailability Onset of action Biological half-life Mean residence time Plasma protein binding Therapeutic index (Median lethal dose, Effective dose)
Pharmacodynamics	Mechanism of action Toxicity (Neurotoxicology) Dose–response relationship (Efficacy, Potency) Antimicrobial pharmacodynamics: Minimum inhibitory concentration (Bacteriostatic) Minimum bactericidal concentration (Bactericide)
Agonism and antagonism	Agonist: Inverse agonist Irreversible agonist Partial agonist Superagonist Physiological agonist Antagonist: Competitive antagonist Irreversible antagonist Physiological antagonist Other: Binding Affinity Binding selectivity Functional selectivity
Other	Drug tolerance: Tachyphylaxis Drug resistance: Antibiotic resistance Multiple drug resistance
Drug discovery strategies	Classical pharmacology Reverse pharmacology
Related fields/subfields	Pharmacogenetics Pharmacogenomics Neuropsychopharmacology (Neuropharmacology, Psychopharmacology)

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