Timeline of tuberculosis

This is a timeline of tuberculosis, describing especially major discoveries, advances in treatment and major organizations.

Big picture

Year/period Key developments
Ancient timesTypical skeletal abnormalities of tuberculosis, including characteristic Pott's deformities, are found in Egyptian mummies and are depicted in early Egyptian art. Tuberculosis is also noted in the Biblical books of Deuteronomy and Leviticus. Written texts describe tuberculosis in India as early as 3300 years ago and in China 2300 years ago. Tuberculosis is well known in classical Greece, where it is called phthisis.[1][2]
Middle Ages and RenaissanceThe incidence of tuberculosis grows progressively in these times, displacing leprosy, peaking between the 18th and 19th century as field workers move to the cities looking for work.[3] In parts of Europe, tuberculosis is known as the “king’s evil” and is widely believed that the kings of England and France can cure scrofula simply by touching those affected.[4]
1700s–1800sDescription of tuberculosis is developed in medical literature. Toward 1800s sanatoria start to open for treating patients, with often successful outcomes. Understanding of the pathogenesis of tuberculosis begins with the works of Laennec, Villemin and the identification of the tubercle bacillus as the etiologic agent by Robert Koch.
1920s–1930sThe International Union Against Tuberculosis (IUAT) is founded. BCG vaccine against tuberculosis is developed. Several international conferences are held, focusing on the fundamental, biological, clinical and social aspects of tuberculosis.[5]
1940s onwardThe isolation of streptomycin is generally considered the beginning of the modern era of tuberculosis. The revolution continues with the development of isoniazid, the first oral mycobactericidal drug. The advent of rifampin in the 1970s hastens recovery times, and significantly reduces the number of tuberculosis cases in the following years.[6][7]
1980s onwardTuberculosis drug-resistant strains appear, provoking a rise in incidence in countries like Britain. Also, the association with AIDS has contributed to the rise of tuberculosis in some sectors.[8]
PresentToday, tuberculosis continues to be a top infectious disease killer worldwide. However, the death rate has dropped 47% since 1990. Over 95% of cases and deaths are in developing countries, with the most severe burden in Africa.[9] At least 1 million children fall ill with tuberculosis each year, represent about 11% of all cases.[10]

Full timeline

Evolution of incidence of tuberculosis cases per WHO region for the period 1990-2014.[11]
Year/period Type of event Event Location
1689DevelopmentEnglish physician Richard Morton first states that tubercles are always present in the tuberculosis disease of the lungs.[12]England
1761DevelopmentAustrian physician Leopold Auenbrugger develops a percussion method for diagnosing tuberculosis.[13]
1768DevelopmentScottish physician Robert Whytt gives the first clinical description of tuberculous meningitis.[14]
1779DevelopmentEnglish surgeon Percivall Pott first describes the arthritic tuberculosis of the spine (today known as Pott disease).[15]
1810DevelopmentFrench physician Gaspard Laurent Bayle publishes his article Recherches sur la Pthisie Pulmonaire, in which he divides phthisis into six types: tubercular phthisis, glandular phthisis, ulcerous phthisis, phthisis with melanosis, calculous phthisis, and cancerous phthisis, basing his findings on more than 900 autopsies.[16]
1816DevelopmentFrench physician René Laennec, working at the Necker-Enfants Malades Hospital, develops the stethoscope, which proves to be a breakthrough. The stethoscope marks a major step in the redefinition of disease from being a bundle of symptoms, to the current sense of a disease as a problem with an anatomical system even if there are no noticeable symptoms. The work of Laennec is considered to have clearly elucidated the pathogenesis of tuberculosis and unified the concept of the disease, whether pulmonary or extrapulmonary.[17][18]Paris, France
1839DevelopmentGerman naturalist Johann Lukas Schönlein is attributed with naming the disease tuberculosis.[19]
1854OrganizationHermann Brehmer establishes the first German sanatorium for the systematic open-air treatment of tuberculosis, with treatment including adjusting lifestyle at high altitude, abundant diet with some alcohol, and exercise in the open air under strict medical supervision. The results are eventually regarded as highly successful, surpassing any previous treatment.[20]Strehlen, Prussia
1865DevelopmentFrench physician Jean Antoine Villemin demonstrates of the transmissibility of mycobacterium tuberculosis.[2]France
1882Discovery German physician Robert Koch, the founder of modern bacteriology, identifies the tubercle bacillus as the etiologic agent that causes tuberculosis. Some years later, Koch develops what today is known as Koch's postulates, which he applies to describe the etiology of cholera and tuberculosis. Koch is also attributed for having created and improved laboratory technologies and techniques in the field of microbiology, and making key discoveries in public health. Koch receives the Nobel Prize in Physiology or Medicine in 1905.[2]
1890DiscoveryHungarian physiologist Franz Tangl publishes what later becomes known as Baumgarten-Tangl law, stating that the location where the bacteria intrudes is the one where the inflammation can be observed first.[21]
1900StudyFrench bacteriologists Albert Calmette and Camille Guérin begin research for an antituberculosis vaccine at the Pasteur Institute.[22]Lille, France
1903OrganizationAmerican entrepreneur Henry Phipps, Jr. founds the Phipps Institute for the Study, Treatment and Prevention of Tuberculosis at the University of Pennsylvania.[23]Philadelphia, US
1904OrganizationThe National Association for the Study and Prevention of Tuberculosis (NASPT) is founded.[24]
1907DevelopmentFrench physician Charles Mantoux introduces his eponymous Mantoux test as a serological skin test to determine whether a person is infected with tuberculosis.[25]
1908DevelopmentFrench physician Charles Mantoux, perfects test for diagnosis of tuberculosis contact (latent tuberculosis).[26]
1909OrganizationAmerican philanthropist Nathan Straus opens the first preventorium for patients infected with tuberculosis.[27]
1921DevelopmentBacillus Calmette–Guérin (BCG) vaccine is first administered. It is still the only vaccine available today against tuberculosis.[22]Paris, France
1930CrisisLübeck disaster. 250 newborn babies are given doses of BCG contaminated by virulent tubercle bacilli. After four to six weeks a large number of the infants develop tuberculosis. 73 babies die in the first year and another 135 are infected but finally recover.[22]Lübeck, Germany
1932DevelopmentThe Löwenstein–Jensen medium is developed as diagnosis for tuberculosis. It is used for culture of Mycobacterium species, notably Mycobacterium tuberculosis.[28]
1936DevelopmentBrazilian physician Manuel de Abreu develops chest photofluorography, a technique for mass screening for tuberculosis.[29]Rio de Janeiro, Brazil
1944DevelopmentSwedish chemist Jörgen Lehmann develops antibiotic 4-Aminosalicylic acid for treating tuberculosis.[30]
1944DevelopmentAlbert Schatz, Elizabeth Bugie, and Selman Waksman at Rutgers University isolate streptomycin, the first antibiotic and first bacterial agent effective against tuberculosis.[31]New Jersey, US
1946–1948TreatmentThe first randomized trial of streptomycin against pulmonary tuberculosis is carried out.[32][33]United States
1948TreatmentResearchers at Britain's Medical Research Council demonstrate that combined treatment with streptomycin and 4-Aminosalicylic acid is superior to either drug alone.[34]UK
1950 Campaign Mass tuberculosis immunization is under way with the BCG vaccine. This vaccine is recommended to be given intradermally, immediately after birth. This vaccine is mandatory to attend school in France between 1950 and 2007, introduced in Brazil in 1967, and to the Philippines in 1979.[35][36][37]
1952DiscoveryIsoniazid is first introduced in clinical treatment for tuberculosis.[2][38]
1952TreatmentAmino acid derivative cycloserine is first isolated. Cycloserine is found to be effective against mycobacterium tuberculosis.[39]
1962TreatmentBacteriostatic drug ethambutol is developed as a medication primarily used to treat tuberculosis.[40]
1971TreatmentAntibiotic rifampicin is first sold as a medication to treat several types of bacterial infections, including tuberculosis.[41]
1976OrganizationThe Seattle Biomedical Research Institute (today known as Center for Infectious Disease Research) is founded as a non-profit organization focused solely on infectious disease discovery research, including tuberculosis.[42][43]Issaquah, Washington, US
1995 Program launch The World Health Organization launches DOTS (Directly Observed Treatment, Short-Course) program as a control strategy for tuberculosis. DOTS works as an intermittent, supervised system of drug intake by patient, which eliminates drug default. DOTS has been described by WHO as "the most important public health breakthrough of the decade in terms of lives saved".[44][45]
1998DevelopmentThe mycobacterium tuberculosis (H37Rv strain) genome is sequenced, with aims at helping scientists develop better therapies, ranging from treatments for tuberculosis to vaccines to prevent it.[46][47]
1999CampaignMédecins Sans Frontières launch the Campaign for Access to Essential Medicines. It pushes to lower the prices of existing drugs, vaccines and diagnostic tests, to stimulate research and development into new treatments for diseases (tuberculosis among them) that primarily affect the poor.[48]
2000OrganizationThe Mycobacterium tuberculosis Structural Genomics Consortium is formed as a worldwide consortium of scientists with the goal of providing a structural basis for the development of therapeutics for tuberculosis. The consortium has five core facilities (located at Lawrence Livermore National Laboratory, Los Alamos National Lab, Lawrence Berkeley National Laboratory, University of California, Los Angeles and Texas A&M University) that carry out an increasing fraction of routine tasks such as protein production, crystallization and X-ray data collection.[49]United States
2000OrganizationThe Global Alliance for TB Drug Development (TB Alliance) is established as a nonprofit organization dedicated to the discovery and development of new, faster-acting and affordable tuberculosis medicines.[50]Cape Town, South Africa
2001OrganizationThe Stop TB Partnership is established with the purpose of eliminating tuberculosis as a public health problem. It has 1000 partner organizations, including international, nongovernmental and governmental organizations and patient groups.[51]Geneva, Switzerland
2002OrganizationThe The Global Fund to Fight AIDS, Tuberculosis and Malaria is founded as an international financing institution dedicated to attract and fund additional resources to stop and treat those diseases.[52]Geneva, Switzerland
2006OrganizationUnitaid is launched as a global health initiative. It provides sustainable funding in order to tackle inefficiencies in markets for medicines, diagnostics and prevention for HIV/AIDS, malaria and tuberculosis in developing countries. UNITAID finances its project through the international solidarity levy on airline tickets that is currently collected in nine out of 29 UNITAID member countries.[53]France, Brazil, Chile, Norway and United Kingdom
2008OrganizationThe The Millennium Foundation for Innovative Finance for Health is established. Its project MassiveGood is meant to collect funds for combating HIV/AIDS, malaria and tuberculosis.[54]United States, United Kingdom, Germany, Austria, Switzerland and Spain (serves worldwide)
2009 WHO calls for universal access to tuberculosis culture by 2015.[28]
2012TreatmentFDA approves bedaquiline for treating multi-drug-resistant tuberculosis. It is the first new medicine for tuberculosis in more than forty years.[55][56] United States
2012Report155 000 people fall ill with tuberculosis in low-incidence countries, averaging 10,000 deaths (30 TB deaths a day).[57]
2012 Report More than 180 countries sign a pledge, vowing to redouble efforts to stop children from dying of preventable diseases, including tuberculosis.[10]
2014Report The World Health Organization and partners launch first-ever targeted and costed roadmap with key steps to scale up the response to childhood tuberculosis and end childhood tuberculosis-related deaths.[10] United States (Washington DC)
2014ReportAt a global level, 9.6 million people fell ill with tuberculosis and 1.5 million died from the disease in 2014.[9]

See also

References

  1. ↑ Thomas, M. Daniel. "The history of tuberculosis". Respiratory Medicine. 100: 1862–1870. doi:10.1016/j.rmed.2006.08.006.
  2. 1 2 3 4 "The history of tuberculosis". Respiratory Medicine. 100: 1862–1870. doi:10.1016/j.rmed.2006.08.006. Retrieved 2 September 2016.
  3. ↑ Aufderheide 1998:129
  4. ↑ "History of Tuberculosis". Retrieved 2 September 2016.
  5. ↑ "History of Tuberculosis". Retrieved 3 September 2016.
  6. ↑ "Box 1: History of tuberculosis drug development". Retrieved 5 September 2016.
  7. ↑ Raviglione, Mario C. Tuberculosis: The Essentials, Fourth Edition. p. 113.
  8. ↑ "Tuberculosis (TB) and other mycobacterial diseases: diagnosis, screening, management and data". Retrieved 10 September 2016.
  9. 1 2 "Tuberculosis". Retrieved 9 September 2016.
  10. 1 2 3 "ENDING TUBERCULOSIS IN CHILDREN" (PDF). WHO. Retrieved 21 January 2017.
  11. ↑ "Mortality and prevalence Data by WHO region (all years)". Retrieved 22 November 2016.
  12. ↑ Kontić, O; Vasiljević, N; Jorga, J; Lakić, A; Jasović-Gasić, M. "Richard Morton (1637-1698)--the distinguished physician of the 17th century". Srp Arh Celok Lek. 137: 706–9. PMID 20069934.
  13. ↑ Walker, Kenneth. "The Origins of the History and Physical Examination". PMID 21250276.
  14. ↑ Breathnach, CS. "Robert Whytt (1714-1766): from dropsy in the brain to tuberculous meningitis.". Ir J Med Sci. 183: 493–9. PMID 24682631. doi:10.1007/s11845-014-1106-3.
  15. ↑ "Pott disease". Retrieved 5 September 2016.
  16. ↑ "Complete Record - Heirs of Hippocrates No. 1291". Retrieved 5 September 2016.
  17. ↑ Duffin, Jacalyn. "Big Ideas: Jacalyn Duffin on the History of the Stethoscope". TVO. Retrieved 9 September 2016.
  18. ↑ "The history of tuberculosis". Respiratory Medicine. 100: 1862–1870. doi:10.1016/j.rmed.2006.08.006. Retrieved 9 September 2016.
  19. ↑ Zur Pathogenie der Impetigines. Auszug aus einer brieflichen Mitteilung an den Herausgeber. [Müller's] Archiv für Anatomie, Physiologie und wissenschaftliche Medicin. 1839, page 82.
  20. ↑ McCarthy, O R (August 2001). "The key to the sanatoria". J R Soc Med. 94: 413–7. PMC 1281640 Freely accessible. PMID 11461990.
  21. ↑ "Baumgarten-Tangl law". Retrieved 4 September 2016.
  22. 1 2 3 Luca, S; Mihaescu, T. "History of BCG Vaccine". Maedica. 8: 53–8. PMC 3749764 Freely accessible. PMID 24023600.
  23. ↑ "HENRY PHIPPS INSTITUTE". Retrieved 5 September 2016.
  24. ↑ "Introduction to the American Lung Association and the Fight against Tuberculosis". Retrieved 2 September 2016.
  25. ↑ Horvat, RT. "Gamma Interferon Assays Used in the Diagnosis of Tuberculosis". Clin Vaccine Immunol. 22: 845–9. PMC 4519719 Freely accessible. PMID 26018533. doi:10.1128/CVI.00199-15.
  26. ↑ Mazana, JS. "Tuberculosis and its eponyms: Charles Mantoux (1877-1947)". Rev Esp Sanid Penit. 11: 17–23. PMID 23128409. doi:10.4321/S1575-06202009000100004.
  27. ↑ "The Garrett Building: An Architectural Record of the Children’s Preventorium Movement". Retrieved 4 September 2016.
  28. 1 2 "Does TB culture impact on clinical decision - making?" (PDF). Retrieved 3 September 2016.
  29. ↑ "Portraits of our lungs". Retrieved 3 September 2016.
  30. ↑ Lehmann, J. (1946). "Para-aminosalicylic acid in the treatment of tuberculosis". Lancet. 1 (6384): 15–16. PMID 21008766. doi:10.1016/s0140-6736(46)91185-3.
  31. ↑ Boyd Woodruff, H. "Selman A. Waksman, Winner of the 1952 Nobel Prize for Physiology or Medicine". Appl Environ Microbiol. 80: 2–8. PMC 3911012 Freely accessible. PMID 24162573. doi:10.1128/AEM.01143-13.
  32. ↑ Comroe JH Jr (1978). "Pay dirt: the story of streptomycin. Part I: from Waksman to Waksman". American Review of Respiratory Disease. 117 (4): 773–781. PMID 417651.
  33. ↑ Kingston W (July 2004). "Streptomycin, Schatz v. Waksman, and the balance of credit for discovery". J Hist Med Allied Sci. 59 (3): 441–62. PMID 15270337. doi:10.1093/jhmas/jrh091.
  34. ↑ Fox, W.; Ellard, G. A.; Mitchison, D. A. (1999). "Studies on the treatment of tuberculosis undertaken by the British Medical Research Council tuberculosis units, 1946-1986, with relevant subsequent publications". The International Journal of Tuberculosis and Lung Disease. 3 (10 Suppl 2): S231–S279. PMID 10529902.
  35. ↑ "WHO in 60 years: a chronology of public health milestones" (PDF). World Health Organization. Retrieved April 2, 2016.
  36. ↑ Loi n° 50-7 du 5 janvier 1950
  37. ↑ décret n° 2007-1111 du 17 juillet 2007
  38. ↑ "Isoniazid Induces Its Own Resistance in Nonreplicating Mycobacterium tuberculosis". Retrieved 3 September 2016.
  39. ↑ Donald, P.R. Antituberculosis Chemotherapy. p. 88.
  40. ↑ Garg, P; Garg, R; Prasad, R; Mishra, AK. "A prospective study of ocular toxicity in patients receiving ethambutol as a part of directly observed treatment strategy therapy". Lung India. 32: 16–9. PMC 4298911 Freely accessible. PMID 25624590. doi:10.4103/0970-2113.148428.
  41. ↑ Oxford Handbook of Infectious Diseases and Microbiology. OUP Oxford. 2009. p. 56. ISBN 978-0-19-103962-1.
  42. ↑ "Seattle Biomedical Research Institute". Retrieved 21 November 2016.
  43. ↑ "Center for Infectious Disease Research". Retrieved 4 September 2016.
  44. ↑ "DOTS". Retrieved 21 November 2016.
  45. ↑ Murali, M S. "DOTS strategy for control of tuberculosis epidemic.". Indian J Med Sci. 56: 16–8. PMID 12508626.
  46. ↑ "1998: M. Tuberculosis Bacterium Sequenced". Retrieved 9 September 2016.
  47. ↑ Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG (June 1998). "Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence". Nature. 393 (6685): 537–44. PMID 9634230. doi:10.1038/31159.
  48. ↑ Butler, Christopher (2007). "Human Rights and the World Trade Organization: The Right to Essential Medicines and the TRIPS Agreement" (PDF). Journal of International Law & Policy. 5: 1–27. Retrieved 4 September 2016.
  49. ↑ "Mycobacterium tuberculosis Structural Genomics Consortium". Retrieved 5 September 2016.
  50. ↑ "Global Alliance for TB Drug Development (TB Alliance)". Retrieved 5 September 2016.
  51. ↑ "Our Hosting Arrangement". Retrieved 4 September 2016.
  52. ↑ "Global Fund Overview". Retrieved 21 November 2016.
  53. ↑ "About UNITAID". Retrieved 5 September 2016.
  54. ↑ "Taskforce on Innovative International Financing for Health Systems: showing the way forward". Retrieved 4 September 2016.
  55. ↑ "FDA Approves 1st New Tuberculosis Drug in 40 Years". ABC News. Retrieved 3 September 2016.
  56. ↑ "F.D.A. Approves New Tuberculosis Drug". New York Times. Retrieved 3 September 2016.
  57. ↑ "TB elimination" (PDF). WHO. Retrieved 21 January 2017.
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