Timeline of antibiotics
This is the timeline of antimicrobial (anti-infective) therapy. The years show when a given drug was released onto the pharmaceutical market. This is not a timeline of the development of the antibiotics themselves.
- 1911 - Arsphenamine a.k.a. Salvarsan[1]
- 1912 - Neosalvarsan
- 1935 - Prontosil (an oral precursor to sulfanilimide), the first sulfonamide
- 1936 - Sulfanilimide
- 1938 - Sulfapyridine (M&B 693)
- 1939 - sulfacetamide
- 1940 - sulfamethizole
- 1942 - benzylpenicillin, the first penicillin
- 1942 - gramicidin S, the first peptide antibiotic
- 1942 - sulfadimidine
- 1943 - sulfamerazine
- 1944 - streptomycin, the first aminoglycoside[2]
- 1947 - sulfadiazine
- 1948 - chlortetracycline, the first tetracycline
- 1949 - chloramphenicol, the first amphenicol[2]
- 1949 - neomycin
- 1950 - oxytetracycline
- 1950 - penicillin G procaine
- 1952 - erythromycin, the first macrolide[2]
- 1954 - benzathine penicillin
- 1955 - spiramycin
- 1955 - tetracycline
- 1955 - thiamphenicol
- 1955 - vancomycin, the first glycopeptide
- 1956 - phenoxymethylpenicillin
- 1958 - colistin, the first polymyxin
- 1958 - demeclocycline
- 1959 - virginiamycin
- 1960 - methicillin
- 1960 - metronidazole, the first nitroimidazole
- 1961 - ampicillin
- 1961 - spectinomycin
- 1961 - sulfamethoxazole
- 1961 - trimethoprim, the first dihydrofolate reductase inhibitor
- 1962 - cloxacillin
- 1962 - fusidic acid
- 1963 - fusafungine
- 1963 - lymecycline
- 1964 - gentamicin
- 1964 - cefalotin, the first cephalosporin
- 1966 - doxycycline
- 1967 - carbenicillin
- 1967 - rifampicin
- 1967 - nalidixic acid, the first quinolone
- 1968 - clindamycin, the second lincosamide
- 1970 - cefalexin
- 1971 - cefazolin
- 1971 - pivampicillin
- 1971 - tinidazole
- 1972 - amoxicillin
- 1972 - cefradine
- 1972 - minocycline
- 1972 - pristinamycin
- 1973 - fosfomycin
- 1974 - talampicillin
- 1975 - tobramycin
- 1975 - bacampicillin
- 1975 - ticarcillin
- 1976 - amikacin
- 1977 - azlocillin
- 1977 - cefadroxil
- 1977 - cefamandole
- 1977 - cefoxitin
- 1977 - cefuroxime
- 1977 - mezlocillin
- 1977 - pivmecillinam
From 1978
- 1979 - cefaclor
- 1980 - cefmetazole
- 1980 - cefotaxime
- 1980 - cefsulodin
- 1980 - piperacillin
- 1981 - co-amoxiclav (amoxicillin/clavulanic acid)
- 1981 - cefoperazone
- 1981 - cefotiam
- 1981 - cefsulodin
- 1981 - latamoxef
- 1981 - netilmicin
- 1982 - ceftriaxone
- 1982 - micronomicin
- 1983 - cefmenoxime
- 1983 - ceftazidime
- 1983 - ceftizoxime
- 1983 - norfloxacin
- 1984 - cefonicid
- 1984 - cefotetan
- 1984 - temocillin
- 1985 - cefpiramide
- 1985 - imipenem/cilastatin, the first carbapenem
- 1985 - ofloxacin
- 1986 - mupirocin
- 1986 - aztreonam
- 1986 - cefoperazone/sulbactam
- 1986 - co-ticarclav (ticarcillin/clavulanic acid)
- 1987 - ampicillin/sulbactam
- 1987 - cefixime
- 1987 - roxithromycin
- 1987 - sultamicillin
- 1987 - ciprofloxacin, the first 2nd-gen fluoroquinolone
- 1987 - rifaximin, the first ansamycin
- 1988 - azithromycin
- 1988 - flomoxef
- 1988 - isepamycin
- 1988 - midecamycin
- 1988 - rifapentine
- 1988 - teicoplanin
- 1989 - cefpodoxime
- 1989 - enrofloxacin
- 1989 - lomefloxacin
- 1989 - moxifloxacin
- 1990 - arbekacin
- 1990 - cefozidime
- 1990 - clarithromycin
- 1991 - cefdinir
- 1992 - cefetamet
- 1992 - cefpirome
- 1992 - cefprozil
- 1992 - ceftibuten
- 1992 - fleroxacin
- 1992 - loracarbef
- 1992 - piperacillin/tazobactam
- 1992 - rufloxacin
- 1993 - brodimoprim
- 1993 - dirithromycin
- 1993 - levofloxacin
- 1993 - nadifloxacin
- 1993 - panipenem/betamipron
- 1993 - sparfloxacin
- 1994 - cefepime
- 1996 - meropenem
- 1999 - quinupristin/dalfopristin
- 2000 - linezolid, the first oxazolidinone
- 2001 - telithromycin, the first ketolide
- 2003 - daptomycin
- 2005 - tigecycline, the first glycylcycline
- 2005 - doripenem
- 2009 - telavancin, the first Lipoglycopeptide
- 2010 - ceftaroline
- 2011 - fidaxomicin
- 2012 - bedaquiline
- 2013 - telavancin
- 2014 - tedizolid
- 2014 - dalbavancin
- 2014 - ceftolozane/tazobactam
- 2015 - ceftazidime/avibactam
See also
- Timeline of medicine and medical technology
- List of antibiotics, grouped by class
References
- ↑ Sepkowitz, Kent A. (Jul 28, 2011). "One Hundred Years of Salvarsan". New England Journal of Medicine. 365 (4): 291–293. PMID 21793743. doi:10.1056/NEJMp1105345.
- 1 2 3 Powers, J. H. (November 2004). "Antimicrobial drug development - the past, the present, and the future". Clinical Microbiology and Infection. 10 (s4): 23–31. PMID 15522037. doi:10.1111/j.1465-0691.2004.1007.x.
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