Thyroid hormone receptor beta

THRB

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1BSX, 1N46, 1NAX, 1NQ0, 1NQ1, 1NQ2, 1NUO, 1Q4X, 1R6G, 1XZX, 1Y0X, 2J4A, 2NLL, 2PIN, 3D57, 3GWS, 3IMY, 3JZC, 4ZO1

Identifiers

Aliases

THRB, C-ERBA-2, C-ERBA-BETA, ERBA2, GRTH, NR1A2, PRTH, THR1, THRB1, THRB2, thyroid hormone receptor beta

External IDs

MGI: 98743 HomoloGene: 36025 GeneCards: THRB

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	No data available	Start	24,117,160 bp^[1]
Band	No data available	End	24,495,282 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 14 (mouse)^[2]

Band	No data available	Start	17,660,960 bp^[2]
Band	No data available	End	18,038,088 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• sequence-specific DNA binding • transcription corepressor activity • zinc ion binding • metal ion binding • steroid hormone receptor activity • protein binding • enzyme binding • chromatin DNA binding • thyroid hormone binding • transcription factor activity, sequence-specific DNA binding • DNA binding • thyroid hormone receptor activity
Cellular component	• nucleoplasm • nuclear chromatin • extracellular exosome • nucleus • nuclear body
Biological process	• regulation of transcription, DNA-templated • regulation of heart contraction • female courtship behavior • regulation of transcription from RNA polymerase II promoter • negative regulation of transcription from RNA polymerase II promoter • sensory perception of sound • Type I pneumocyte differentiation • negative regulation of female receptivity • animal organ morphogenesis • transcription initiation from RNA polymerase II promoter • negative regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • steroid hormone mediated signaling pathway • intracellular receptor signaling pathway • transcription, DNA-templated
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


7068


21834

Ensembl


ENSG00000151090


ENSMUSG00000021779

UniProt


P10828


P37242

RefSeq (mRNA)


NM_000461 NM_001128176 NM_001128177 NM_001252634


NM_001113417 NM_009380

RefSeq (protein)


NP_000452 NP_001121648 NP_001121649 NP_001239563


NP_001106888 NP_033406

Location (UCSC)

Chr 3: 24.12 – 24.5 Mb

Chr 3: 17.66 – 18.04 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Thyroid hormone receptor beta (TR-beta) also known as nuclear receptor subfamily 1, group A, member 2 (NR1A2), is a nuclear receptor protein that in humans is encoded by the THRB gene.^[5]^[6]

Function

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Defects in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T₃-T₄), with normal or slightly elevated thyroid stimulating hormone (TSH). Several transcript variants have been observed for this gene, but the full-length nature of only one has been observed so far.^[7]

Interactions

Thyroid hormone receptor beta has been shown to interact with:

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000151090 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021779 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "Entrez Gene: THRA thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)".
↑ Sakurai A, Nakai A, DeGroot LJ (June 1990). "Structural analysis of human thyroid hormone receptor beta gene". Mol. Cell. Endocrinol. 71 (2): 83–91. PMID 1973914. doi:10.1016/0303-7207(90)90245-4.
↑ "Entrez Gene: THRB thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)".
1 2 Monden T, Wondisford FE, Hollenberg AN (November 1997). "Isolation and characterization of a novel ligand-dependent thyroid hormone receptor-coactivating protein". J. Biol. Chem. 272 (47): 29834–41. PMID 9368056. doi:10.1074/jbc.272.47.29834.
↑ Lin HM, Zhao L, Cheng SY (August 2002). "Cyclin D1 Is a Ligand-independent Co-repressor for Thyroid Hormone Receptors". J. Biol. Chem. 277 (32): 28733–41. PMID 12048199. doi:10.1074/jbc.M203380200.
1 2 Liu Y, Takeshita A, Misiti S, Chin WW, Yen PM (October 1998). "Lack of coactivator interaction can be a mechanism for dominant negative activity by mutant thyroid hormone receptors". Endocrinology. 139 (10): 4197–204. PMID 9751500. doi:10.1210/endo.139.10.6218.
1 2 Jeyakumar M, Tanen MR, Bagchi MK (June 1997). "Analysis of the functional role of steroid receptor coactivator-1 in ligand-induced transactivation by thyroid hormone receptor". Mol. Endocrinol. 11 (6): 755–67. PMID 9171239. doi:10.1210/mend.11.6.0003.
↑ Lee SK, Jung SY, Kim YS, Na SY, Lee YC, Lee JW (February 2001). "Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2". Mol. Endocrinol. 15 (2): 241–54. PMID 11158331. doi:10.1210/me.15.2.241.
↑ Lee SK, Anzick SL, Choi JE, Bubendorf L, Guan XY, Jung YK, Kallioniemi OP, Kononen J, Trent JM, Azorsa D, Jhun BH, Cheong JH, Lee YC, Meltzer PS, Lee JW (November 1999). "A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo". J. Biol. Chem. 274 (48): 34283–93. PMID 10567404. doi:10.1074/jbc.274.48.34283.
↑ Ko L, Cardona GR, Chin WW (May 2000). "Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator". Proc. Natl. Acad. Sci. U.S.A. 97 (11): 6212–7. PMC 18584 . PMID 10823961. doi:10.1073/pnas.97.11.6212.
↑ Ko L, Cardona GR, Iwasaki T, Bramlett KS, Burris TP, Chin WW (January 2002). "Ser-884 adjacent to the LXXLL motif of coactivator TRBP defines selectivity for ERs and TRs". Mol. Endocrinol. 16 (1): 128–40. PMID 11773444. doi:10.1210/mend.16.1.0755.
↑ Tagami T, Lutz WH, Kumar R, Jameson JL (December 1998). "The interaction of the vitamin D receptor with nuclear receptor corepressors and coactivators". Biochem. Biophys. Res. Commun. 253 (2): 358–63. PMID 9878542. doi:10.1006/bbrc.1998.9799.
↑ Ando S, Sarlis NJ, Krishnan J, Feng X, Refetoff S, Zhang MQ, Oldfield EH, Yen PM (September 2001). "Aberrant alternative splicing of thyroid hormone receptor in a TSH-secreting pituitary tumor is a mechanism for hormone resistance". Mol. Endocrinol. 15 (9): 1529–38. PMID 11518802. doi:10.1210/me.15.9.1529.
↑ Zhu XG, Park KS, Kaneshige M, Bhat MK, Zhu Q, Mariash CN, McPhie P, Cheng SY (April 2000). "The orphan nuclear receptor Ear-2 is a negative coregulator for thyroid hormone nuclear receptor function". Mol. Cell. Biol. 20 (7): 2604–18. PMC 85476 . PMID 10713182. doi:10.1128/MCB.20.7.2604-2618.2000.
↑ Wu Y, Delerive P, Chin WW, Burris TP (March 2002). "Requirement of helix 1 and the AF-2 domain of the thyroid hormone receptor for coactivation by PGC-1". J. Biol. Chem. 277 (11): 8898–905. PMID 11751919. doi:10.1074/jbc.M110761200.

Lazar MA, Chin WW (1990). "Nuclear thyroid hormone receptors". J. Clin. Invest. 86 (6): 1777–82. PMC 329808 . PMID 2254444. doi:10.1172/JCI114906.
Forrest D, Reh TA, Rüsch A (2002). "Neurodevelopmental control by thyroid hormone receptors". Curr. Opin. Neurobiol. 12 (1): 49–56. PMID 11861164. doi:10.1016/S0959-4388(02)00289-1.
González-Sancho JM, García V, Bonilla F, Muñoz A (2003). "Thyroid hormone receptors/THR genes in human cancer". Cancer Lett. 192 (2): 121–32. PMID 12668276. doi:10.1016/S0304-3835(02)00614-6.
Cugini CD, Leidy JW, Chertow BS, Bérard J, Bradley WE, Menke JB, Hao EH, Usala SJ (1992). "An arginine to histidine mutation in codon 315 of the c-erbA beta thyroid hormone receptor in a kindred with generalized resistance to thyroid hormones results in a receptor with significant 3,5,3'-triiodothyronine binding activity". J. Clin. Endocrinol. Metab. 74 (5): 1164–70. PMID 1314846. doi:10.1210/jc.74.5.1164.
Behr M, Loos U (1992). "A point mutation (Ala229 to Thr) in the hinge domain of the c-erbA beta thyroid hormone receptor gene in a family with generalized thyroid hormone resistance". Mol. Endocrinol. 6 (7): 1119–26. PMID 1324420. doi:10.1210/me.6.7.1119.
Falcone M, Miyamoto T, Fierro-Renoy F, Macchia E, DeGroot LJ (1992). "Antipeptide polyclonal antibodies specifically recognize each human thyroid hormone receptor isoform". Endocrinology. 131 (5): 2419–29. PMID 1425440. doi:10.1210/en.131.5.2419.
Schmidt ED, Schmidt ED, van der Gaag R, Ganpat R, Broersma L, de Boer PA, Moorman AF, Lamers WH, Wiersinga WM, Koornneef L (1992). "Distribution of the nuclear thyroid-hormone receptor in extraocular and skeletal muscles". J. Endocrinol. 133 (1): 67–74. PMID 1517709. doi:10.1677/joe.0.1330067.
Adams M, Nagaya T, Tone Y, Jameson JL, Chatterjee VK (1992). "Functional properties of a novel mutant thyroid hormone receptor in a family with generalized thyroid hormone resistance syndrome". Clin. Endocrinol. (Oxf). 36 (3): 281–9. PMID 1563081. doi:10.1111/j.1365-2265.1992.tb01444.x.
Sasaki S, Nakamura H, Tagami T, Miyoshi Y, Tanaka K, Imura H (1992). "A point mutation of the T3 receptor beta 1 gene in a kindred of generalized resistance to thyroid hormone". Mol. Cell. Endocrinol. 84 (3): 159–66. PMID 1587388. doi:10.1016/0303-7207(92)90026-3.
Nagaya T, Madison LD, Jameson JL (1992). "Thyroid hormone receptor mutants that cause resistance to thyroid hormone. Evidence for receptor competition for DNA sequences in target genes". J. Biol. Chem. 267 (18): 13014–9. PMID 1618799.
Shuto Y, Wakabayashi I, Amuro N, Minami S, Okazaki T (1992). "A point mutation in the 3,5,3'-triiodothyronine-binding domain of thyroid hormone receptor-beta associated with a family with generalized resistance to thyroid hormone". J. Clin. Endocrinol. Metab. 75 (1): 213–7. PMID 1619012. doi:10.1210/jc.75.1.213.
Näär AM, Boutin JM, Lipkin SM, Yu VC, Holloway JM, Glass CK, Rosenfeld MG (1991). "The orientation and spacing of core DNA-binding motifs dictate selective transcriptional responses to three nuclear receptors". Cell. 65 (7): 1267–79. PMID 1648451. doi:10.1016/0092-8674(91)90021-P.
Usala SJ, Menke JB, Watson TL, Wondisford FE, Weintraub BD, Bérard J, Bradley WE, Ono S, Mueller OT, Bercu BB (1991). "A homozygous deletion in the c-erbA beta thyroid hormone receptor gene in a patient with generalized thyroid hormone resistance: isolation and characterization of the mutant receptor". Mol. Endocrinol. 5 (3): 327–35. PMID 1653889. doi:10.1210/mend-5-3-327.
Bodenner DL, Mroczynski MA, Weintraub BD, Radovick S, Wondisford FE (1991). "A detailed functional and structural analysis of a major thyroid hormone inhibitory element in the human thyrotropin beta-subunit gene". J. Biol. Chem. 266 (32): 21666–73. PMID 1657975.
Parrilla R, Mixson AJ, McPherson JA, McClaskey JH, Weintraub BD (1991). "Characterization of seven novel mutations of the c-erbA beta gene in unrelated kindreds with generalized thyroid hormone resistance. Evidence for two "hot spot" regions of the ligand binding domain". J. Clin. Invest. 88 (6): 2123–30. PMC 295818 . PMID 1661299. doi:10.1172/JCI115542.
Usala SJ, Menke JB, Watson TL, Bérard WE, Bradley C, Bale AE, Lash RW, Weintraub BD (1991). "A new point mutation in the 3,5,3'-triiodothyronine-binding domain of the c-erbA beta thyroid hormone receptor is tightly linked to generalized thyroid hormone resistance". J. Clin. Endocrinol. Metab. 72 (1): 32–8. PMID 1846005. doi:10.1210/jcem-72-1-32.
Usala SJ, Tennyson GE, Bale AE, Lash RW, Gesundheit N, Wondisford FE, Accili D, Hauser P, Weintraub BD (1990). "A base mutation of the C-erbA beta thyroid hormone receptor in a kindred with generalized thyroid hormone resistance. Molecular heterogeneity in two other kindreds". J. Clin. Invest. 85 (1): 93–100. PMC 296391 . PMID 2153155. doi:10.1172/JCI114438.
Sakurai A, Takeda K, Ain K, Ceccarelli P, Nakai A, Seino S, Bell GI, Refetoff S, DeGroot LJ (1989). "Generalized resistance to thyroid hormone associated with a mutation in the ligand-binding domain of the human thyroid hormone receptor beta". Proc. Natl. Acad. Sci. U.S.A. 86 (22): 8977–81. PMC 298414 . PMID 2510172. doi:10.1073/pnas.86.22.8977.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

PDB gallery

1bsx: STRUCTURE AND SPECIFICITY OF NUCLEAR RECEPTOR-COACTIVATOR INTERACTIONS

1n46: CRYSTAL STRUCTURE OF HUMAN TR BETA LIGAND-BINDING DOMAIN COMPLEXED WITH A POTENT SUBTYPE-SELECTIVE THYROMIMETIC

1nax: Thyroid receptor beta1 in complex with a beta-selective ligand

1nq0: TR Receptor Mutations Conferring Hormone Resistance and Reduced Corepressor Release Exhibit Decreased Stability in the Nterminal LBD

1nq1: TR Receptor Mutations Conferring Hormone Resistance and Reduced Corepressor Release Exhibit Decreased Stability in the Nterminal LBD

1nq2: Two RTH Mutants with Impaired Hormone Binding

1nuo: Two RTH Mutants with Impaired Hormone Binding

1q4x: Crystal Structure of Human Thyroid Hormone Receptor beta LBD in complex with specific agonist GC-24

1r6g: Crystal structure of the thyroid hormone receptor beta ligand binding domain in complex with a beta selective compound

1xzx: Thyroxine-Thyroid Hormone Receptor Interactions

1y0x: Thyroxine-Thyroid Hormone Receptor Interactions

2h6w:

2nll: RETINOID X RECEPTOR-THYROID HORMONE RECEPTOR DNA-BINDING DOMAIN HETERODIMER BOUND TO THYROID RESPONSE ELEMENT DNA

Transcription factors and intracellular receptors

(1) Basic domains

(1.1) Basic leucine zipper (bZIP)	Activating transcription factor AATF 1 2 3 4 5 6 7 AP-1 c-Fos FOSB FOSL1 FOSL2 JDP2 c-Jun JUNB JunD BACH 1 2 BATF BLZF1 C/EBP α β γ δ ε ζ CREB 1 3 L1 CREM DBP DDIT3 GABPA GCN4 HLF MAF B F G K NFE 2 L1 L2 L3 NFIL3 NRL NRF 1 2 3 XBP1
(1.2) Basic helix-loop-helix (bHLH)	ATOH1 AhR AHRR ARNT ASCL1 BHLH 2 3 9 ARNTL ARNTL ARNTL2 CLOCK EPAS1 FIGLA HAND 1 2 HES 5 6 HEY 1 2 L HES1 HIF 1A 3A ID 1 2 3 4 LYL1 MESP2 MXD4 MYCL1 MYCN Myogenic regulatory factors MyoD Myogenin MYF5 MYF6 Neurogenins 1 2 3 NeuroD 1 2 NPAS 1 2 3 OLIG 1 2 Pho4 Scleraxis SIM 1 2 TAL 1 2 Twist USF1
(1.3) bHLH-ZIP	AP-4 MAX MXD3 MITF MNT MLX MXI1 Myc SREBP 1 2
(1.4) NF-1	NFI A B C X SMAD R-SMAD 1 2 3 5 9 I-SMAD 6 7 4)
(1.5) RF-X	RFX 1 2 3 4 5 6 ANK
(1.6) Basic helix-span-helix (bHSH)	AP-2 α β γ δ ε

(2) Zinc finger DNA-binding domains

(2.1) Nuclear receptor (Cys₄)

subfamily 1	Thyroid hormone α β CAR FXR LXR α β PPAR α β/δ γ PXR RAR α β γ ROR α β γ Rev-ErbA α β VDR
subfamily 2	COUP-TF (I II Ear-2 HNF4 α γ PNR RXR α β γ Testicular receptor 2 4 TLX
subfamily 3	Steroid hormone Androgen Estrogen α β Glucocorticoid Mineralocorticoid Progesterone Estrogen related α β γ
subfamily 4	NUR NGFIB NOR1 NURR1
subfamily 5	LRH-1 SF1
subfamily 6	GCNF
subfamily 0	DAX1 SHP

(2.2) Other Cys₄

GATA
- 1
- 2
- 3
- 4
- 5
- 6
MTA
- 1
- 2
- 3
TRPS1

(2.3) Cys₂His₂

General transcription factors
- TFIIA
- TFIIB
- TFIID
- TFIIE
  - 1
  - 2
- TFIIF
- 1
- 2
  - TFIIH
  - 1
  - 2
  - 4
  - 2I
  - 3A
  - 3C1
  - 3C2

ATBF1
BCL
- 6
- 11A
- 11B
CTCF
E4F1
EGR
- 1
- 2
- 3
- 4
ERV3
GFI1
GLI-Krüppel family
- 1
- 2
- 3
- REST
- S1
- S2
- YY1
HIC
- 1
- 2
HIVEP
- 1
- 2
- 3
IKZF
- 1
- 2
- 3
ILF
- 2
- 3
KLF
- 1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
- 10
- 11
- 12
- 13
- 14
- 15
- 17
MTF1
MYT1
OSR1
PRDM9
SALL
- 1
- 2
- 3
- 4
SP
- 1
- 2
- 4
- 7
- 8
TSHZ3
WT1
Zbtb7
- 7A
- 7B
ZBTB
- 11
- 16
- 17
- 20
- 32
- 33
- 40
zinc finger
- 3
- 7
- 9
- 10
- 19
- 22
- 24
- 33B
- 34
- 35
- 41
- 43
- 44
- 51
- 74
- 143
- 146
- 148
- 165
- 202
- 217
- 219
- 238
- 239
- 259
- 267
- 268
- 281
- 295
- 300
- 318
- 330
- 346
- 350
- 365
- 366
- 384
- 423
- 451
- 452
- 471
- 593
- 638
- 644
- 649
- 655

(2.4) Cys₆

HIVEP1

(2.5) Alternating composition

AIRE
DIDO1
GRLF1
ING
- 1
- 2
- 4
JARID
- 1A
- 1B
- 1C
- 1D
- 2
JMJD1B

(2.6) WRKY

WRKY

(3) Helix-turn-helix domains

(3.1) Homeodomain	ARX CDX 1 2 CRX CUTL1 DBX 1 2 DLX 3 4 5 EMX 1 2 EN 1 2 FHL 1 2 3 HESX1 HHEX HLX Homeobox A1 A2 A3 A4 A5 A7 A9 A10 A11 A13 B1 B2 B3 B4 B5 B6 B7 B8 B9 B13 C4 C5 C6 C8 C9 C10 C11 C12 C13 D1 D3 D4 D8 D9 D10 D11 D12 D13 HOPX IRX 1 2 3 4 5 6 MKX LMX 1A 1B MEIS 1 2 MEOX2 MNX1 MSX 1 2 NANOG NKX 2-1 2-2 2-3 2-5 3-1 3-2 6-1 6-2 NOBOX PBX 1 2 3 PHF 1 3 6 8 10 16 17 20 21A PHOX 2A 2B PITX 1 2 3 POU domain PIT-1 BRN-3: A B C Octamer transcription factor: 1 2 3/4 6 7 11 OTX 1 2 PDX1 SATB2 SHOX2 SIX 1 2 3 4 5 VAX1 ZEB 1 2
(3.2) Paired box	PAX 1 2 3 4 5 6 7 8 9 PRRX 1 2 RAX
(3.3) Fork head / winged helix	E2F 1 2 3 4 5 FOX proteins A1 A2 A3 C1 C2 D3 D4 E1 E3 F1 G1 H1 I1 J1 J2 K1 K2 L2 M1 N1 N3 O1 O3 O4 P1 P2 P3 P4
(3.4) Heat shock factors	HSF 1 2 4
(3.5) Tryptophan clusters	ELF 2 4 5 EGF ELK 1 3 4 ERF ETS 1 2 ERG SPIB ETV 1 4 5 6 FLI1 Interferon regulatory factors 1 2 3 4 5 6 7 8 MYB MYBL2
(3.6) TEA domain	transcriptional enhancer factor 1 2 3 4

(4) β-Scaffold factors with minor groove contacts

(4.1) Rel homology region	NF-κB NFKB1 NFKB2 REL RELA RELB NFAT C1 C2 C3 C4 5
(4.2) STAT	STAT 1 2 3 4 5 6
(4.3) p53	p53 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF TP63
(4.4) MADS box	Mef2 A B C D SRF
(4.6) TATA-binding proteins	TBP TBPL1
(4.7) High-mobility group	BBX HMGB 1 2 3 4 HMGN 1 2 3 4 HNF 1A 1B LEF1 SOX 1 2 3 4 5 6 8 9 10 11 12 13 14 15 18 21 SRY SSRP1 TCF 3 4 TOX 1 2 3 4
(4.9) Grainyhead	TFCP2
(4.10) Cold-shock domain	CSDA YBX1
(4.11) Runt	CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1

(0) Other transcription factors

(0.2) HMGI(Y)	HMGA 1 2 HBP1
(0.3) Pocket domain	Rb RBL1 RBL2
(0.5) AP-2/EREBP-related factors	Apetala 2 EREBP B3
(0.6) Miscellaneous	ARID 1A 1B 2 3A 3B 4A CAP IFI 16 35 MLL 2 3 T1 MNDA NFY A B C Rho/Sigma

see also transcription factor/coregulator deficiencies

Thyroid hormone receptor modulators

THR
(ligands)

Agonists	Dextrothyroxine DIMIT DITPA Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 Levothyroxine Liothyronine Liotrix MB-07344 MB-07811 MGL-3196 (VIA-3196) Sobetirome (GC-1, GRX-431) Thyroxine Tiratricol (TRIAC) Triiodothyronine Thyroid extract VK-0214 VK-2809 ZYT1
Antagonists	1-850 NH3 Tetraiodothyroacetic acid (Tetrac)

Transporter
(inhibitors)

NIS	Cyanogenic glycosides Perchlorates (e.g., potassium perchlorate) Pertechnetates (e.g., sodium pertechnetate) Thiocyanates

Enzyme
(inhibitors)

TPO	Benzylthiouracil Carbimazole Genistein Methimazole Methylthiouracil Propylthiouracil Thiouracil Thiourea
DIO	Dexpropranolol Iopanoic acid Ipodate sodium (sodium iopodate) Propranolol Propylthiouracil

Others

See also: Receptor/signaling modulators
Nuclear receptor modulators

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

Thyroid hormone receptor beta

Function

Interactions

References

Further reading