TUBG1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1Z5V, 1Z5W, 3CB2

Identifiers

Aliases

TUBG1, CDCBM4, GCP-1, TUBG, TUBGCP1, tubulin gamma 1

External IDs

MGI: 101834 HomoloGene: 833 GeneCards: TUBG1

Gene location (Human)

Chr.	Chromosome 17 (human)^[1]

Band	No data available	Start	42,609,676 bp^[1]
Band	No data available	End	42,615,234 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	No data available	Start	101,119,938 bp^[2]
Band	No data available	End	101,126,419 bp^[2]

Gene ontology
Molecular function	• nucleotide binding • GTP binding • structural constituent of cytoskeleton • protein binding • GTPase activity
Cellular component	• cytoplasm • ciliary basal body • recycling endosome • cytosol • centrosome • pericentriolar material • apical part of cell • gamma-tubulin complex • cilium • microtubule organizing center • condensed nuclear chromosome • spindle microtubule • polar microtubule • cell leading edge • centriole • cytoplasmic microtubule • microtubule • cytoskeleton • non-motile cilium
Biological process	• meiotic spindle organization • G2/M transition of mitotic cell cycle • cytoplasmic microtubule organization • microtubule-based process • microtubule cytoskeleton organization • microtubule nucleation • ciliary basal body docking • regulation of G2/M transition of mitotic cell cycle
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


7283


103733

Ensembl


ENSG00000131462


ENSMUSG00000035198

UniProt


P23258


P83887

RefSeq (mRNA)


NM_001070


NM_134024

RefSeq (protein)


NP_001061


NP_598785

Location (UCSC)

Chr 17: 42.61 – 42.62 Mb

Chr 17: 101.12 – 101.13 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Tubulin, gamma 1 is a protein in humans that is encoded by the TUBG1 gene.^[5] This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000131462 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035198 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "Entrez Gene: Tubulin, gamma 1".

Zhang X, Chen Q, Feng J, Hou J, Yang F, Liu J, Jiang Q, Zhang C (July 2009). "Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the gammaTuRC to the centrosome". Journal of Cell Science. 122 (Pt 13): 2240–51. PMID 19509060. doi:10.1242/jcs.042747.
Lau AS, Mruk DD (April 2003). "Rab8B GTPase and junction dynamics in the testis". Endocrinology. 144 (4): 1549–63. PMID 12639940. doi:10.1210/en.2002-220893.
Feng Y, Olson EC, Stukenberg PT, Flanagan LA, Kirschner MW, Walsh CA (December 2000). "LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome". Neuron. 28 (3): 665–79. PMID 11163258. doi:10.1016/S0896-6273(00)00145-8.
Hsu LC, White RL (October 1998). "BRCA1 is associated with the centrosome during mitosis". Proceedings of the National Academy of Sciences of the United States of America. 95 (22): 12983–8. PMC 23679 . PMID 9789027. doi:10.1073/pnas.95.22.12983.
Manning JA, Shalini S, Risk JM, Day CL, Kumar S (March 2010). Hotchin NA, ed. "A direct interaction with NEDD1 regulates gamma-tubulin recruitment to the centrosome". PloS One. 5 (3): e9618. PMC 2835750 . PMID 20224777. doi:10.1371/journal.pone.0009618.
Aldaz H, Rice LM, Stearns T, Agard DA (May 2005). "Insights into microtubule nucleation from the crystal structure of human gamma-tubulin". Nature. 435 (7041): 523–7. PMID 15917813. doi:10.1038/nature03586.
Niu Y, Liu T, Tse GM, Sun B, Niu R, Li HM, Wang H, Yang Y, Ye X, Wang Y, Yu Q, Zhang F (April 2009). "Increased expression of centrosomal alpha, gamma-tubulin in atypical ductal hyperplasia and carcinoma of the breast". Cancer Science. 100 (4): 580–7. PMID 19215229. doi:10.1111/j.1349-7006.2008.01075.x.
Hampe C, Ardila-Osorio H, Fournier M, Brice A, Corti O (July 2006). "Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin-protein ligase with monoubiquitylation capacity". Human Molecular Genetics. 15 (13): 2059–75. PMID 16714300. doi:10.1093/hmg/ddl131.
Zyss D, Montcourrier P, Vidal B, Anguille C, Mérezègue F, Sahuquet A, Mangeat PH, Coopman PJ (December 2005). "The Syk tyrosine kinase localizes to the centrosomes and negatively affects mitotic progression". Cancer Research. 65 (23): 10872–80. PMID 16322234. doi:10.1158/0008-5472.CAN-05-1270.

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TUBG1

References

Further reading