TTLL1

TTLL1

Identifiers

TTLL1, C22orf7, HS323M22B, tubulin tyrosine ligase like 1

External IDs

MGI: 2443047 HomoloGene: 8174 GeneCards: TTLL1

Gene location (Human)

Chr.	Chromosome 22 (human)^[1]

Band	No data available	Start	43,039,644 bp^[1]
Band	No data available	End	43,089,428 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 15 (mouse)^[2]

Band	No data available	Start	83,483,772 bp^[2]
Band	No data available	End	83,510,893 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• nucleotide binding • ligase activity • ATP binding • tubulin-glutamic acid ligase activity
Cellular component	• cytoplasm • microtubule • cytoskeleton
Biological process	• epithelial cilium movement • protein polyglutamylation • cellular protein modification process • axoneme assembly • sperm axoneme assembly • sperm flagellum movement involved in flagellated sperm motility
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


25809


319953


ENSG00000100271


ENSMUSG00000022442


O95922


Q91V51

RefSeq (mRNA)


NM_001008572 NM_012263


NM_178869

RefSeq (protein)


NP_036395


NP_849200

Location (UCSC)

Chr 22: 43.04 – 43.09 Mb

Chr 22: 83.48 – 83.51 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Probable tubulin polyglutamylase TTLL1 is an enzyme that in humans is encoded by the TTLL1 gene.^[5]^[6]^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000100271 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022442 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. PMID 10591208. doi:10.1038/990031.
↑ Trichet V, Ruault M, Roizes G, De Sario A (Dec 2000). "Characterization of the human tubulin tyrosine ligase-like 1 gene (TTLL1) mapping to 22q13.1". Gene. 257 (1): 109–17. PMID 11054573. doi:10.1016/S0378-1119(00)00383-8.
↑ "Entrez Gene: TTLL1 tubulin tyrosine ligase-like family, member 1".

Further reading

Nagase T, Seki N, Ishikawa K, et al. (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 3 (1): 17–24. PMID 8724849. doi:10.1093/dnares/3.1.17.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. PMC 311072 . PMID 11230166. doi:10.1101/gr.GR1547R.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Collins JE, Goward ME, Cole CG, et al. (2003). "Reevaluating Human Gene Annotation: A Second-Generation Analysis of Chromosome 22". Genome Res. 13 (1): 27–36. PMC 430954 . PMID 12529303. doi:10.1101/gr.695703.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. PMC 545604 . PMID 15461802. doi:10.1186/gb-2004-5-10-r84.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Janke C, Rogowski K, Wloga D, et al. (2005). "Tubulin polyglutamylase enzymes are members of the TTL domain protein family". Science. 308 (5729): 1758–62. PMID 15890843. doi:10.1126/science.1113010.

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