TSPY1
| TSPY1 |
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| Identifiers |
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| Aliases | TSPY1, CT78, DYS14, TSPY, pJA923, testis specific protein, Y-linked 1 |
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| External IDs | HomoloGene: 87844 GeneCards: TSPY1 |
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| Gene location (Human) |
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 | | Chr. | Y chromosome (human)[1] |
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| | Band | No data available | Start | 9,466,955 bp[1] |
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| End | 9,469,748 bp[1] |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr Y: 9.47 – 9.47 Mb | n/a |
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| PubMed search | [2] | n/a |
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| Wikidata |
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Testis-specific Y-encoded protein 1 is a protein that in humans is encoded by the TSPY1 gene.[3]
The protein encoded by this gene is found only in testicular tissue and may be involved in spermatogenesis. Approximately 35 copies of this gene are present in humans, but only a single, nonfunctional orthologous gene is found in mice. Two transcript variants encoding different isoforms have been found for this gene.[4]
See also
References
Further reading
- Chandley AC, Cooke HJ (1995). "Human male fertility--Y-linked genes and spermatogenesis.". Hum. Mol. Genet. 3. Spec No: 1449–52. PMID 7849736.
- Vogel T, Schmidtke J (1998). "Structure and function of TSPY, the Y-chromosome gene coding for the "testis-specific protein".". Cytogenet. Cell Genet. 80 (1-4): 209–13. PMID 9678360. doi:10.1159/000014982.
- Lau YF (2000). "Gonadoblastoma, testicular and prostate cancers, and the TSPY gene.". Am. J. Hum. Genet. 64 (4): 921–7. PMC 1377814
. PMID 10090875. doi:10.1086/302353.
- Zhang JS, Yang-Feng TL, Muller U, et al. (1993). "Molecular isolation and characterization of an expressed gene from the human Y chromosome.". Hum. Mol. Genet. 1 (9): 717–26. PMID 1284595. doi:10.1093/hmg/1.9.717.
- Arnemann J, Jakubiczka S, Thüring S, Schmidtke J (1992). "Cloning and sequence analysis of a human Y-chromosome-derived, testicular cDNA, TSPY.". Genomics. 11 (1): 108–14. PMID 1765369. doi:10.1016/0888-7543(91)90107-P.
- Arnemann J, Epplen JT, Cooke HJ, et al. (1988). "A human Y-chromosomal DNA sequence expressed in testicular tissue.". Nucleic Acids Res. 15 (21): 8713–24. PMC 306400 . PMID 3479749. doi:10.1093/nar/15.21.8713.
- Manz E, Schnieders F, Brechlin AM, Schmidtke J (1993). "TSPY-related sequences represent a microheterogeneous gene family organized as constitutive elements in DYZ5 tandem repeat units on the human Y chromosome.". Genomics. 17 (3): 726–31. PMID 8244388. doi:10.1006/geno.1993.1393.
- Kim HS, Takenaka O (1996). "A comparison of TSPY genes from Y-chromosomal DNA of the great apes and humans: sequence, evolution, and phylogeny.". Am. J. Phys. Anthropol. 100 (3): 301–9. PMID 8798990. doi:10.1002/(SICI)1096-8644(199607)100:3<301::AID-AJPA1>3.0.CO;2-X.
- Schnieders F, Dörk T, Arnemann J, et al. (1997). "Testis-specific protein, Y-encoded (TSPY) expression in testicular tissues.". Hum. Mol. Genet. 5 (11): 1801–7. PMID 8923009. doi:10.1093/hmg/5.11.1801.
- Vogt PH, Affara N, Davey P, et al. (1998). "Report of the Third International Workshop on Y Chromosome Mapping 1997. Heidelberg, Germany, April 13-16, 1997.". Cytogenet. Cell Genet. 79 (1-2): 1–20. PMID 9533010. doi:10.1159/000134680.
- Vogel T, Dittrich O, Mehraein Y, et al. (1998). "Murine and human TSPYL genes: novel members of the TSPY-SET-NAP1L1 family.". Cytogenet. Cell Genet. 81 (3-4): 265–70. PMID 9730615. doi:10.1159/000015042.
- Lau YF, Zhang J (2000). "Expression analysis of thirty one Y chromosome genes in human prostate cancer.". Mol. Carcinog. 27 (4): 308–21. PMID 10747295. doi:10.1002/(SICI)1098-2744(200004)27:4<308::AID-MC9>3.0.CO;2-R.
- Ratti A, Stuppia L, Gatta V, et al. (2000). "Characterization of a new TSPY gene family member in Yq (TSPYq1).". Cytogenet. Cell Genet. 88 (1-2): 159–62. PMID 10773691. doi:10.1159/000015510.
- Dechend F, Williams G, Skawran B, et al. (2001). "TSPY variants in six loci on the human Y chromosome.". Cytogenet. Cell Genet. 91 (1-4): 67–71. PMID 11173833. doi:10.1159/000056821.
- Lau Y, Chou P, Iezzoni J, et al. (2001). "Expression of a candidate gene for the gonadoblastoma locus in gonadoblastoma and testicular seminoma.". Cytogenet. Cell Genet. 91 (1-4): 160–4. PMID 11173850. doi:10.1159/000056838.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Krick R, Jakubiczka S, Arnemann J (2003). "Expression, alternative splicing and haplotype analysis of transcribed testis specific protein (TSPY) genes.". Gene. 302 (1-2): 11–9. PMID 12527192. doi:10.1016/S0378-1119(02)01104-6.
