TSC22D1
TSC22 domain family protein 1 is a protein that in humans is encoded by the TSC22D1 gene.[5][6]
TSC22 encodes a transcription factor and belongs to the large family of early response genes.[7]
TSC22D1 forms homodimers via its conserved leucine zipper domain and heterodimerizes with TSC22D4. TSC22D1 has transcriptional repressor activity.[8]
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000102804 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022010 - Ensembl, May 2017
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Jay P, Ji JW, Marsollier C, Taviaux S, Berge-Lefranc JL, Berta P (Jul 1996). "Cloning of the human homologue of the TGF beta-stimulated clone 22 gene". Biochem Biophys Res Commun. 222 (3): 821–6. PMID 8651929. doi:10.1006/bbrc.1996.0825.
- ↑ Ohta S, Shimekake Y, Nagata K (Mar 1997). "Molecular cloning and characterization of a transcription factor for the C-type natriuretic peptide gene promoter". Eur J Biochem. 242 (3): 460–6. PMID 9022669. doi:10.1111/j.1432-1033.1996.460rr.x.
- ↑ "Entrez Gene: TSC22D1 TSC22 domain family, member 1".
- ↑ Kester HA, Blanchetot C, den Hertog J, van der Saag PT, van der Burg B (September 1999). "Transforming growth factor-beta-stimulated clone-22 is a member of a family of leucine zipper proteins that can homo- and heterodimerize and has transcriptional repressor activity". J. Biol. Chem. 274 (39): 27439–47. PMID 10488076. doi:10.1074/jbc.274.39.27439.
Further reading
- Shibanuma M, Kuroki T, Nose K (1992). "Isolation of a gene encoding a putative leucine zipper structure that is induced by transforming growth factor beta 1 and other growth factors.". J. Biol. Chem. 267 (15): 10219–24. PMID 1587811.
- Dmitrenko VV, Garifulin OM, Shostak EA, et al. (1997). "[The characteristics of different types of mRNA expressed in the human brain]". Tsitol. Genet. 30 (5): 41–7. PMID 9026990.
- Kester HA, Blanchetot C, den Hertog J, et al. (1999). "Transforming growth factor-beta-stimulated clone-22 is a member of a family of leucine zipper proteins that can homo- and heterodimerize and has transcriptional repressor activity.". J. Biol. Chem. 274 (39): 27439–47. PMID 10488076. doi:10.1074/jbc.274.39.27439.
- Hino S, Kawamata H, Uchida D, et al. (2001). "Nuclear translocation of TSC-22 (TGF-beta-stimulated clone-22) concomitant with apoptosis: TSC-22 as a putative transcriptional regulator.". Biochem. Biophys. Res. Commun. 278 (3): 659–64. PMID 11095965. doi:10.1006/bbrc.2000.3840.
- Hino S, Kawamata H, Omotehara F, et al. (2002). "Leucine zipper structure of TSC-22 (TGF-beta stimulated clone-22) markedly inhibits the anchorage-independent growth of salivary gland cancer cells.". Oncol. Rep. 9 (2): 371–4. PMID 11836610. doi:10.3892/or.9.2.371.
- Hino S, Kawamata H, Omotehara F, et al. (2002). "Cytoplasmic TSC-22 (transforming growth factor-beta-stimulated clone-22) markedly enhances the radiation sensitivity of salivary gland cancer cells.". Biochem. Biophys. Res. Commun. 292 (4): 957–63. PMID 11944908. doi:10.1006/bbrc.2002.6776.
- Ohara O, Nagase T, Mitsui G, et al. (2003). "Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method.". DNA Res. 9 (2): 47–57. PMID 12056414. doi:10.1093/dnares/9.2.47.
- Gupta RA, Sarraf P, Brockman JA, et al. (2003). "Peroxisome proliferator-activated receptor gamma and transforming growth factor-beta pathways inhibit intestinal epithelial cell growth by regulating levels of TSC-22.". J. Biol. Chem. 278 (9): 7431–8. PMID 12468551. doi:10.1074/jbc.M208076200.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Sugawara F, Yamada Y, Watanabe R, et al. (2004). "The role of the TSC-22 (-396) A/G variant in the development of diabetic nephropathy.". Diabetes Res. Clin. Pract. 60 (3): 191–7. PMID 12757981. doi:10.1016/S0168-8227(03)00038-X.
- Uchida D, Omotehara F, Nakashiro K, et al. (2003). "Posttranscriptional regulation of TSC-22 (TGF-beta-stimulated clone-22) gene by TGF-beta 1.". Biochem. Biophys. Res. Commun. 305 (4): 846–54. PMID 12767908. doi:10.1016/S0006-291X(03)00854-4.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Choi SJ, Moon JH, Ahn YW, et al. (2005). "Tsc-22 enhances TGF-beta signaling by associating with Smad4 and induces erythroid cell differentiation.". Mol. Cell. Biochem. 271 (1-2): 23–8. PMID 15881652. doi:10.1007/s11010-005-3456-7.
- Rentsch CA, Cecchini MG, Schwaninger R, et al. (2006). "Differential expression of TGFbeta-stimulated clone 22 in normal prostate and prostate cancer.". Int. J. Cancer. 118 (4): 899–906. PMID 16106424. doi:10.1002/ijc.21449.
- Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell. 122 (6): 957–68. PMID 16169070. doi:10.1016/j.cell.2005.08.029.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. PMC 1847948 . PMID 17353931. doi:10.1038/msb4100134.
- Lu Y, Kitaura J, Oki T, et al. (2007). "Identification of TSC-22 as a potential tumor suppressor that is upregulated by Flt3-D835V but not Flt3-ITD.". Leukemia. 21 (11): 2246–57. PMID 17690703. doi:10.1038/sj.leu.2404883.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.