TRPM7

TRPM7
Identifiers
AliasesTRPM7, ALSPDC, CHAK, CHAK1, LTRPC7, LTrpC-7, TRP-PLIK, transient receptor potential cation channel subfamily M member 7
External IDsOMIM: 605692 MGI: 1929996 HomoloGene: 9774 GeneCards: TRPM7
Gene location (Human)
Chr.Chromosome 15 (human)[1]
BandNo data availableStart50,552,473 bp[1]
End50,686,815 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

54822

58800

Ensembl

ENSG00000092439

ENSMUSG00000027365

UniProt

Q96QT4

Q923J1

RefSeq (mRNA)

NM_001301212
NM_017672

NM_001164325
NM_021450

RefSeq (protein)

NP_001288141
NP_060142

NP_001157797
NP_067425

Location (UCSC)Chr 15: 50.55 – 50.69 MbChr 15: 126.79 – 126.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transient receptor potential cation channel, subfamily M, member 7, also known as TRPM7, is a human gene encoding a protein of the same name.

Function

TRPs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell. TRP-PLIK is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutants.[supplied by OMIM][5]

Interactions

TRPM7 has been shown to interact with PLCB1[6] and PLCB2.[6]

Clinical relevance

Defects in this gene have been associated to magnesium deficiency in human microvascular endothelial cells.[7]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000092439 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027365 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: TRPM7 transient receptor potential cation channel, subfamily M, member 7".
  6. 1 2 Runnels LW, Yue L, Clapham DE (May 2002). "The TRPM7 channel is inactivated by PIP(2) hydrolysis". Nat. Cell Biol. 4 (5): 329–36. PMID 11941371. doi:10.1038/ncb781.
  7. ↑ Baldoli E, Maier JA (20 December 2011). "Silencing TRPM7 mimics the effects of magnesium deficiency in human microvascular endothelial cells". Angiogenesis. 15 (1): 47–57. PMID 22183257. doi:10.1007/s10456-011-9242-0. Check date values in: |year= / |date= mismatch (help)

Further reading

  • Chubanov V, Gudermann T, Schlingmann KP (2005). "Essential role for TRPM6 in epithelial magnesium transport and body magnesium homeostasis". Pflugers Arch. 451 (1): 228–34. PMID 16075242. doi:10.1007/s00424-005-1470-y. 
  • Clapham DE, Julius D, Montell C, Schultz G (2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. PMID 16382100. doi:10.1124/pr.57.4.6. 
  • Penner R, Fleig A (2007). "The Mg2+ and Mg(2+)-nucleotide-regulated channel-kinase TRPM7". Handb Exp Pharmacol. 179 (179): 313–28. PMID 17217066. doi:10.1007/978-3-540-34891-7_19. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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