TRNA dimethylallyltransferase

TRNA dimethylallyltransferase
Identifiers
EC number 2.5.1.75
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

TRNA dimethylallyltransferase (EC 2.5.1.75, tRNA prenyltransferase, MiaA, transfer ribonucleate isopentenyltransferase, Delta2-isopentenyl pyrophosphate:tRNA-Delta2-isopentenyl transferase, Delta2-isopentenyl pyrophosphate:transfer ribonucleic acid Delta2-isopentenyltransferase) is an enzyme with systematic name dimethylallyl-diphosphate: tRNA dimethylallyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction

dimethylallyl diphosphate + tRNA diphosphate + tRNA containing 6-dimethylallyladenosine

Formerly known as tRNA isopentenyltransferase (EC 2.5.1.8), but it is now known that dimethylallyl diphosphate, rather than isopentenyl diphosphate, is the substrate.

References

  1. ↑ Leung, H.C.; Chen, Y.; Winkler, M.E. (1997). "Regulation of substrate recognition by the MiaA tRNA prenyltransferase modification enzyme of Escherichia coli K-12". J. Biol. Chem. 272 (20): 13073–13083. PMID 9148919. doi:10.1074/jbc.272.20.13073.
  2. ↑ Soderberg, T.; Poulter, C.D. (2000). "Escherichia coli dimethylallyl diphosphate:tRNA dimethylallyltransferase: essential elements for recognition of tRNA substrates within the anticodon stem-loop". Biochemistry. 39 (21): 6546–6553. PMID 10828971. doi:10.1021/bi992775u.
  3. ↑ Moore, J.A.; Mathis, J.R.; Poulter, C.D. (2000). "Escherichia coli dimethylallyl diphosphate: tRNA dimethylallyltransferase: pre-steady-state kinetic studies". Biochim. Biophys. Acta. 1479 (1–2): 166–174. PMID 11004538. doi:10.1016/S0167-4838(00)00031-5.
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