TRNA (guanine37-N1)-methyltransferase

TRNA (guanine³⁷-N¹)-methyltransferase (EC 2.1.1.228, TrmD, tRNA (m1G37) methyltransferase, transfer RNA (m1G37) methyltransferase, Trm5p, TRMT5, tRNA-(N1G37) methyltransferase, MJ0883 (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (guanine³⁷-N¹)-methyltransferase.^[1]^[2]^[3]^[4]^[5]^[6] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + guanine³⁷ in tRNA

\rightleftharpoons

S-adenosyl-L-homocysteine + N¹-methylguanine³⁷ in tRNA

This enzyme is important for the maintenance of the correct reading frame during translation.

References

↑ Takeda, H.; Toyooka, T.; Ikeuchi, Y.; Yokobori, S.; Okadome, K.; Takano, F.; Oshima, T.; Suzuki, T.; Endo, Y.; Hori, H. (2006). "The substrate specificity of tRNA (m¹G³⁷) methyltransferase (TrmD) from Aquifex aeolicus". Genes Cells. 11: 1353–1365. PMID 17121543. doi:10.1111/j.1365-2443.2006.01022.x.
↑ Lee, C.; Kramer, G.; Graham, D.E.; Appling, D.R. (2007). "Yeast mitochondrial initiator tRNA is methylated at guanosine 37 by the Trm5-encoded tRNA (guanine-N¹-)-methyltransferase". J. Biol. Chem. 282: 27744–27753. PMID 17652090. doi:10.1074/jbc.m704572200.
↑ O'Dwyer, K.; Watts, J.M.; Biswas, S.; Ambrad, J.; Barber, M.; Brule, H.; Petit, C.; Holmes, D.J.; Zalacain, M.; Holmes, W.M. (2004). "Characterization of Streptococcus pneumoniae TrmD, a tRNA methyltransferase essential for growth". J. Bacteriol. 186: 2346–2354. PMC 412112 . PMID 15060037. doi:10.1128/jb.186.8.2346-2354.2004.
↑ Brule, H.; Elliott, M.; Redlak, M.; Zehner, Z.E.; Holmes, W.M. (2004). "Isolation and characterization of the human tRNA-(N1G37) methyltransferase (TRM5) and comparison to the Escherichia coli TrmD protein". Biochemistry. 43: 9243–9255. PMID 15248782. doi:10.1021/bi049671q.
↑ Goto-Ito, S.; Ito, T.; Ishii, R.; Muto, Y.; Bessho, Y.; Yokoyama, S. (2008). "Crystal structure of archaeal RNA(m¹G37)methyltransferase aTrm5". Proteins. 72: 1274–1289. PMID 18384044. doi:10.1002/prot.22019.
↑ Ahn, H.J.; Kim, H.W.; Yoon, H.J.; Lee, B.I.; Suh, S.W.; Yang, J.K. (2003). "Crystal structure of tRNA(m¹G³⁷)methyltransferase: insights into tRNA recognition". EMBO J. 22: 2593–2603. PMC 156765 . PMID 12773376. doi:10.1093/emboj/cdg269.

External links

TRNA (guanine37-N1)-methyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)

Transferase: one carbon transferases (EC 2.1)

2.1.1: Methyl-

N-	Histamine N-methyltransferase Phenylethanolamine N-methyltransferase Amine N-methyltransferase Phosphatidylethanolamine N-methyltransferase
O-	5-hydroxyindole-O-methyltransferase/Acetylserotonin O-methyltransferase Catechol-O-methyl transferase
Homocysteine	Betaine-homocysteine methyltransferase Homocysteine methyltransferase Methionine synthase
Other	Phosphatidyl ethanolamine methyltransferase DNMT3B Histone methyltransferase Thymidylate synthase DNA methyltransferase Thiopurine methyltransferase

2.1.2: Hydroxymethyl-,
Formyl- and Related

Hydroxymethyltransferase	Serine hydroxymethyltransferase 3-methyl-2-oxobutanoate hydroxymethyltransferase
Formyltransferase	Phosphoribosylglycinamide formyltransferase Inosine monophosphate synthase
Other	Glutamate formimidoyltransferase Aminomethyltransferase

2.1.3: Carboxy-
and Carbamoyl

Carboxy	methylmalonyl-CoA carboxytransferase
Carbamoyl	Aspartate carbamoyltransferase Ornithine carbamoyltransferase Oxamate carbamoyltransferase Putrescine carbamoyltransferase 3-hydroxymethylcephem carbamoyltransferase Lysine carbamoyltransferase N-acetylornithine carbamoyltransferase

2.1.4: Amidine

Arginine:glycine amidinotransferase

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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