TRIM6
Tripartite motif-containing protein 6 is a protein that in humans is encoded by the TRIM6 gene.[5][6]
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the nucleus, but its specific function has not been identified. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. A read-through transcript transcribed from this gene and TRIM34 has been observed.[6]
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000121236 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000072244 - Ensembl, May 2017
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. PMC 125245
. PMID 11331580. doi:10.1093/emboj/20.9.2140. - 1 2 "Entrez Gene: TRIM6 tripartite motif-containing 6".
Further reading
- Li X, Gold B, O'hUigin C, et al. (2007). "Unique features of TRIM5alpha among closely related human TRIM family members.". Virology. 360 (2): 419–33. PMID 17156811. doi:10.1016/j.virol.2006.10.035.
- Zhang F, Hatziioannou T, Perez-Caballero D, et al. (2006). "Antiretroviral potential of human tripartite motif-5 and related proteins.". Virology. 353 (2): 396–409. PMID 16828831. doi:10.1016/j.virol.2006.05.035.
- Li X, Li Y, Stremlau M, et al. (2006). "Functional replacement of the RING, B-box 2, and coiled-coil domains of tripartite motif 5alpha (TRIM5alpha) by heterologous TRIM domains.". J. Virol. 80 (13): 6198–206. PMC 1488960 . PMID 16775307. doi:10.1128/JVI.00283-06.
- Woo JS, Imm JH, Min CK, et al. (2006). "Structural and functional insights into the B30.2/SPRY domain.". EMBO J. 25 (6): 1353–63. PMC 1422157 . PMID 16498413. doi:10.1038/sj.emboj.7600994.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Orimo A, Tominaga N, Yoshimura K, et al. (2001). "Molecular cloning of ring finger protein 21 (RNF21)/interferon-responsive finger protein (ifp1), which possesses two RING-B box-coiled coil domains in tandem.". Genomics. 69 (1): 143–9. PMID 11013086. doi:10.1006/geno.2000.6318.
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