TREX2

TREX2

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1Y97

Identifiers

TREX2, three prime repair exonuclease 2

External IDs

MGI: 1346343 HomoloGene: 8046 GeneCards: TREX2

Gene location (Human)

Chr.	X chromosome (human)^[1]

Band	No data available	Start	153,444,720 bp^[1]
Band	No data available	End	153,470,587 bp^[1]

Gene location (Mouse)

Chr.	X chromosome (mouse)^[2]

Band	No data available	Start	73,433,705 bp^[2]
Band	No data available	End	73,435,344 bp^[2]

Gene ontology
Molecular function	• nuclease activity • exodeoxyribonuclease III activity • exonuclease activity • hydrolase activity • protein homodimerization activity • magnesium ion binding • 3'-5'-exodeoxyribonuclease activity • metal ion binding • nucleic acid binding • 3'-5' exonuclease activity
Cellular component	• nucleus
Biological process	• DNA repair • cellular response to DNA damage stimulus • nucleic acid phosphodiester bond hydrolysis • DNA metabolic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


11219


24102


ENSG00000183479


ENSMUSG00000031372


Q9BQ50


Q9R1A9

RefSeq (mRNA)


NM_080701 NM_080699 NM_080700


NM_011907

RefSeq (protein)


NP_542432


NP_036037

Location (UCSC)

Chr X: 153.44 – 153.47 Mb

Chr X: 73.43 – 73.44 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Three prime repair exonuclease 2 is an enzyme that in humans is encoded by the TREX2 gene.^[5]^[6]

This gene encodes a protein with 3' exonuclease activity. Enzymes with this activity are involved in DNA replication, repair, and recombination. Similarity to an E. coli protein suggests that this enzyme may be a subunit of DNA polymerase III, which does not have intrinsic exonuclease activity.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000183479 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031372 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Mazur DJ, Perrino FW (Aug 1999). "Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases". J Biol Chem. 274 (28): 19655–60. PMID 10391904. doi:10.1074/jbc.274.28.19655.
1 2 "Entrez Gene: TREX2 three prime repair exonuclease 2".

Further reading

Shevelev IV, Hübscher U (2002). "The 3' 5' exonucleases.". Nat. Rev. Mol. Cell Biol. 3 (5): 364–76. PMID 11988770. doi:10.1038/nrm804.
Esposito T, Ciccodicola A, Flagiello L, et al. (1997). "Expressed STSs and transcription of human Xq28.". Gene. 187 (2): 185–91. PMID 9099879. doi:10.1016/S0378-1119(96)00772-X.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMC 310948 . PMID 11076863. doi:10.1101/gr.143000.
Li T, Duan W, Yang H, et al. (2001). "Identification of two proteins, S14 and UIP1, that interact with UCH37.". FEBS Lett. 488 (3): 201–5. PMID 11163772. doi:10.1016/S0014-5793(00)02436-4.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. PMC 1083732 . PMID 11256614. doi:10.1093/embo-reports/kvd058.
Mazur DJ, Perrino FW (2001). "Structure and expression of the TREX1 and TREX2 3' --> 5' exonuclease genes.". J. Biol. Chem. 276 (18): 14718–27. PMID 11278605. doi:10.1074/jbc.M010051200.
Mazur DJ, Perrino FW (2001). "Excision of 3' termini by the Trex1 and TREX2 3'-->5' exonucleases. Characterization of the recombinant proteins.". J. Biol. Chem. 276 (20): 17022–9. PMID 11279105. doi:10.1074/jbc.M100623200.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Shevelev IV, Beliakova NV, Kravetskaia TP, Krutiakov VM (2003). "[The correcting role of autonomous 3'-->5' exonucleases in mammalian multienzyme DNA polymerase complexes]". Mol. Biol. (Mosk.). 36 (6): 1055–61. PMID 12500544.
Shevelev IV, Ramadan K, Hübscher U (2004). "The TREX2 3'-->5' exonuclease physically interacts with DNA polymerase delta and increases its accuracy.". ScientificWorldJournal. 2: 275–81. PMID 12806015. doi:10.1100/tsw.2002.99.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. PMC 528930 . PMID 15489336. doi:10.1101/gr.2576704.
Perrino FW, Krol A, Harvey S, et al. (2005). "Sequence variants in the 3'-->5' deoxyribonuclease TREX2: identification in a genetic screen and effects on catalysis by the recombinant proteins.". Adv. Enzyme Regul. 44: 37–49. PMID 15581481. doi:10.1016/j.advenzreg.2003.11.010.
Perrino FW, Harvey S, McMillin S, Hollis T (2005). "The human TREX2 3' -> 5'-exonuclease structure suggests a mechanism for efficient nonprocessive DNA catalysis.". J. Biol. Chem. 280 (15): 15212–8. PMID 15661738. doi:10.1074/jbc.M500108200.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. PMC 1347501 . PMID 16381901. doi:10.1093/nar/gkj139.
Hahn Y, Lee B (2007). "Human-specific nonsense mutations identified by genome sequence comparisons.". Hum. Genet. 119 (1-2): 169–78. PMID 16395595. doi:10.1007/s00439-005-0125-6.
Chen MJ, Ma SM, Dumitrache LC, Hasty P (2007). "Biochemical and cellular characteristics of the 3' -> 5' exonuclease TREX2.". Nucleic Acids Res. 35 (8): 2682–94. PMC 1885668 . PMID 17426129. doi:10.1093/nar/gkm151.

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