TPPP
Tubulin polymerization-promoting protein is a protein that in humans is encoded by the TPPP gene.[5][6][7][8][9]
This protein has been linked to multiple sclerosis myelin lesions and CSF abnormalities in multiple sclerosis patients.[10]
This has also been linked to Parkinson's and Alsheimers Disease[11][12]
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000171368 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021573 - Ensembl, May 2017
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Seki N, Hattori A, Sugano S, Suzuki Y, Nakagawara A, Muramatsu M, Hori T, Saito T (Apr 1999). "A novel human gene whose product shares significant homology with the bovine brain-specific protein p25 on chromosome 5p15.3". J Hum Genet. 44 (2): 121–2. PMID 10083737. doi:10.1007/s100380050122.
- ↑ Hlavanda E, Kovacs J, Olah J, Orosz F, Medzihradszky KF, Ovadi J (Jul 2002). "Brain-specific p25 protein binds to tubulin and microtubules and induces aberrant microtubule assemblies at substoichiometric concentrations". Biochemistry. 41 (27): 8657–64. PMID 12093283. doi:10.1021/bi020140g.
- ↑ Lindersson E, Lundvig D, Petersen C, Madsen P, Nyengaard JR, Hojrup P, Moos T, Otzen D, Gai WP, Blumbergs PC, Jensen PH (Feb 2005). "p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies". J Biol Chem. 280 (7): 5703–15. PMID 15590652. doi:10.1074/jbc.M410409200.
- ↑ Vincze O, Tokesi N, Olah J, Hlavanda E, Zotter A, Horvath I, Lehotzky A, Tirian L, Medzihradszky KF, Kovacs J, Orosz F, Ovadi J (Nov 2006). "Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions". Biochemistry. 45 (46): 13818–26. PMID 17105200. doi:10.1021/bi061305e.
- ↑ "Entrez Gene: TPPP brain-specific protein p25 alpha".
- ↑ Vincze O, Oláh J, Zádori D, Klivényi P, Vécsei L, Ovádi J (May 2011). "A new myelin protein, TPPP/p25, reduced in demyelinated lesions is enriched in cerebrospinal fluid of multiple sclerosis". Biochem. Biophys. Res. Commun. 409 (1): 137–41. PMID 21565174. doi:10.1016/j.bbrc.2011.04.130.
- ↑ Kovács, Gábor G.; László, Lajos; Kovács, János; Jensen, Poul Henning; Lindersson, Evo; Botond, Gergő; Molnár, Tamás; Perczel, András; Hudecz, Ferenc (2004-11-01). "Natively unfolded tubulin polymerization promoting protein TPPP/p25 is a common marker of alpha-synucleinopathies". Neurobiology of Disease. 17 (2): 155–162. doi:10.1016/j.nbd.2004.06.006.
- ↑ Kovács, Gábor G.; Gelpi, Ellen; Lehotzky, Attila; Höftberger, Romana; Erdei, Anna; Budka, Herbert; Ovádi, Judit (2006-11-23). "The brain-specific protein TPPP/p25 in pathological protein deposits of neurodegenerative diseases". Acta Neuropathologica. 113 (2): 153–161. ISSN 0001-6322. PMID 17123092. doi:10.1007/s00401-006-0167-4.
Further reading
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548. doi:10.1101/gr.6.9.791.
- Martín CP, Vázquez J, Avila J, Moreno FJ (2002). "P24, a glycogen synthase kinase 3 (GSK 3) inhibitor.". Biochim. Biophys. Acta. 1586 (1): 113–22. PMID 11781156. doi:10.1016/s0925-4439(01)00092-8.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241
. PMID 12477932. doi:10.1073/pnas.242603899. - Tirián L, Hlavanda E, Oláh J, et al. (2004). "TPPP/p25 promotes tubulin assemblies and blocks mitotic spindle formation.". Proc. Natl. Acad. Sci. U.S.A. 100 (24): 13976–81. PMC 283531 . PMID 14623963. doi:10.1073/pnas.2436331100.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Lehotzky A, Tirián L, Tökési N, et al. (2005). "Dynamic targeting of microtubules by TPPP/p25 affects cell survival.". J. Cell. Sci. 117 (Pt 25): 6249–59. PMID 15564385. doi:10.1242/jcs.01550.
- DeGiorgis JA, Jaffe H, Moreira JE, et al. (2005). "Phosphoproteomic analysis of synaptosomes from human cerebral cortex.". J. Proteome Res. 4 (2): 306–15. PMID 15822905. doi:10.1021/pr0498436.
- Jämsä A, Bäckström A, Gustafsson E, et al. (2006). "Glutamate treatment and p25 transfection increase Cdk5 mediated tau phosphorylation in SH-SY5Y cells.". Biochem. Biophys. Res. Commun. 345 (1): 324–31. PMID 16678793. doi:10.1016/j.bbrc.2006.04.032.
- Skjoerringe T, Lundvig DM, Jensen PH, Moos T (2006). "P25alpha/Tubulin polymerization promoting protein expression by myelinating oligodendrocytes of the developing rat brain.". J. Neurochem. 99 (1): 333–42. PMID 16879710. doi:10.1111/j.1471-4159.2006.04073.x.
- Oláh J, Tokési N, Vincze O, et al. (2006). "Interaction of TPPP/p25 protein with glyceraldehyde-3-phosphate dehydrogenase and their co-localization in Lewy bodies.". FEBS Lett. 580 (25): 5807–14. PMID 17027006. doi:10.1016/j.febslet.2006.09.037.
- Hlavanda E, Klement E, Kókai E, et al. (2007). "Phosphorylation blocks the activity of tubulin polymerization-promoting protein (TPPP): identification of sites targeted by different kinases.". J. Biol. Chem. 282 (40): 29531–9. PMID 17693641. doi:10.1074/jbc.M703466200.
- Song YJ, Lundvig DM, Huang Y, et al. (2007). "p25alpha relocalizes in oligodendroglia from myelin to cytoplasmic inclusions in multiple system atrophy.". Am. J. Pathol. 171 (4): 1291–303. PMC 1988878 . PMID 17823288. doi:10.2353/ajpath.2007.070201.
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