TOLLIP

TOLLIP
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTOLLIP, IL-1RAcPIP, toll interacting protein
External IDsMGI: 1891808 HomoloGene: 10375 GeneCards: TOLLIP
Gene location (Human)
Chr.Chromosome 11 (human)[1]
BandNo data availableStart1,274,371 bp[1]
End1,309,654 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

54472

54473

Ensembl

ENSG00000078902

ENSMUSG00000025139

UniProt

Q9H0E2
Q6FIE9

Q9QZ06

RefSeq (mRNA)

NM_019009
NM_001318512
NM_001318514
NM_001318515
NM_001318516

NM_023764
NM_001347562

RefSeq (protein)

NP_001334491
NP_076253

Location (UCSC)Chr 11: 1.27 – 1.31 MbChr 11: 141.87 – 141.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Toll interacting protein, also known as TOLLIP, is an inhibitory adaptor protein that in humans is encoded by the TOLLIP gene.[5][6][7]

Function

It is an inhibitory adaptor protein within Toll-like receptors (TLR).[8] The TLR pathway is a part of the innate immune system that recognizes structurally conserved molecular patterns of microbial pathogens, leading to an inflammatory immune response.

Clinical significance

Polymorphisms in TLR genes have been implicated in various diseases like atopic dermatitis.[9] Recently, variations in the TOLLIP gene have been associated with tuberculosis and idiopathic pulmonary fibrosis.[10][11]

Interactions

TOLLIP has been shown to interact with TOM1,[12] TLR 2,[13] TLR 4[13] and IL1RAP.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000078902 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025139 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: TOLLIP toll interacting protein".
  6. ↑ Volpe F, Clatworthy J, Kaptein A, Maschera B, Griffin AM, Ray K (December 1997). "The IL1 receptor accessory protein is responsible for the recruitment of the interleukin-1 receptor associated kinase to the IL1/IL1 receptor I complex". FEBS Lett. 419 (1): 41–4. PMID 9426216. doi:10.1016/S0014-5793(97)01426-9.
  7. 1 2 Burns K, Clatworthy J, Martin L, Martinon F, Plumpton C, Maschera B, Lewis A, Ray K, Tschopp J, Volpe F (June 2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor". Nat. Cell Biol. 2 (6): 346–51. PMID 10854325. doi:10.1038/35014038.
  8. ↑ Bulut Y, Faure E, Thomas L, Equils O, Arditi M (July 2001). "Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling". J. Immunol. 167 (2): 987–94. PMID 11441107. doi:10.4049/jimmunol.167.2.987.
  9. ↑ Schimming TT, Parwez Q, Petrasch-Parwez E, Nothnagel M, Epplen JT, Hoffjan S (2007). "Association of toll-interacting protein gene polymorphisms with atopic dermatitis". BMC Dermatol. 7: 3. PMC 1832210 Freely accessible. PMID 17362526. doi:10.1186/1471-5945-7-3.
  10. ↑ Shah JA, Vary JC, Chau TT, Bang ND, Yen NT, Farrar JJ, Dunstan SJ, Hawn TR (2012). "Human TOLLIP Regulates TLR2 and TLR4 Signaling and Its Polymorphisms Are Associated with Susceptibility to Tuberculosis". J Immunol. 189 (4): 1737–46. PMC 3428135 Freely accessible. PMID 22778396. doi:10.4049/jimmunol.1103541.
  11. ↑ "Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study". The Lancet Respiratory Medicine. 1 (4): 309–317. doi:10.1016/S2213-2600(13)70045-6.
  12. ↑ Yamakami, Megumi; Yoshimori Tamotsu; Yokosawa Hideyoshi (Dec 2003). "Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin". J. Biol. Chem. United States. 278 (52): 52865–72. ISSN 0021-9258. PMID 14563850. doi:10.1074/jbc.M306740200.
  13. 1 2 Zhang, Guolong; Ghosh Sankar (Mar 2002). "Negative regulation of toll-like receptor-mediated signaling by Tollip". J. Biol. Chem. United States. 277 (9): 7059–65. ISSN 0021-9258. PMID 11751856. doi:10.1074/jbc.M109537200.

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.