TOG superfamily
The transporter-opsin-G protein-coupled receptor (TOG) superfamily is a protein superfamily of integral membrane proteins, usually of 7 or 8 transmembrane alpha-helical segments (TMSs). It includes (1) ion-translocating microbial rhodopsins and (2) G protein-coupled receptors (GPCRs), (3) Sweet sugar transporters, (4) nicotinamide ribonucleoside uptake permeases (PnuC; TC# 4.B.1), (5) 4-toluene sulfonate uptake permeases (TSUP); TC# 2.A.102), (6) Ni2+–Co2+ transporters (NiCoT); TC# 2.A.52), (7) organic solute transporters (OST); TC# 2.A.82), (8) phosphate:Na+ symporters (PNaS); TC# 2.A.58) and (9) lysosomal cystine transporters (LCT); TC# 2.A.43).[1] [2]
Families
Currently recognized families within the TOG Superfamily (with TC numbers in blue) include:[3]
- 1.A.14 - The Testis-enhanced Gene Transfer (TEGT) Family
- 1.A.26 - The Mg2+ Transporter-E (MgtE) Family
- 1.A.76 - The Magnesium Transporter1 (MagT1) Family
- 2.A.43 - The Lysosomal Cystine Transporter (LCT) Family
- 2.A.52 - The Ni2+-Co2+ Transporter (NiCoT) Family
- 2.A.58 - The Phosphate:Na+ Symporter (PNaS) Family
- 2.A.82 - The Organic Solute Transporter (OST) Family
- 2.A.102 - The 4-Toluene Sulfonate Uptake Permease (TSUP) Family
- 2.A.123 - The Sweet; PQ-loop; Saliva; MtN3 (Sweet) Family
- 3.E.1 - The Ion-translocating Microbial Rhodopsin (MR) Family
- 4.B.1 - The Nicotinamide Ribonucleoside (NR) Uptake Permease (PnuC) Family
- 9.A.14 - The G-protein-coupled receptor (GPCR) Family
Structures
A couple of the 3-D structures available for members of the following families include:
- SWEET family: 4RNG
- MR family: 5AXO, 3T45 - high resolution structures
- PnuC family: 4QTN
- GPCR family: 3CAP
See also
References
- ↑ Maksim A. Shlykov; Wei Hao Zheng; Jonathan S. Chen & Milton H. Saier, Jr.. (March 2012). "Bioinformatic Characterization of the 4-Toluene Sulfonate Uptake Permease (TSUP) Family of Transmembrane Proteins.". Biochimica et Biophysica Acta. 1818 (3): 703–717. PMC 3917603
. PMID 22192777. doi:10.1016/j.bbamem.2011.12.005. - ↑ Yee DC1, Shlykov MA, Västermark A, Reddy VS, Arora S, Sun EI, Saier MH Jr.. (September 2013). "The transporter-opsin-G protein-coupled receptor (TOG) superfamily.". The FEBS Journal. 280 (22): 5780–5800. PMC 3832197 . PMID 23981446. doi:10.1111/febs.12499.
- ↑ Saier, Milton. "Transporter-Opsin-G protein-coupled receptor (TOG) Superfamily". tcdb.org. Retrieved 28 December 2015.
Further reading
- Yee DC1, Shlykov MA, Västermark A, Reddy VS, Arora S, Sun EI, Saier MH Jr.. (September 2013). "The transporter-opsin-G protein-coupled receptor (TOG) superfamily.". The FEBS Journal. 280 (22): 5780–5800. PMC 3832197 . PMID 23981446. doi:10.1111/febs.12499.