TNPO2

TNPO2

Identifiers

TNPO2, IPO3, KPNB2B, TRN2, transportin 2

External IDs

MGI: 2384849 HomoloGene: 8381 GeneCards: TNPO2

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	No data available	Start	12,699,194 bp^[1]
Band	No data available	End	12,724,011 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 8 (mouse)^[2]

Band	No data available	Start	85,036,915 bp^[2]
Band	No data available	End	85,057,583 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• protein transporter activity • protein binding • nuclear localization sequence binding • Ran GTPase binding
Cellular component	• nuclear membrane • nuclear periphery • nucleus • cytoplasm
Biological process	• protein transport • protein import into nucleus, translocation • intracellular protein transport • ribosomal protein import into nucleus • NLS-bearing protein import into nucleus • transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


30000


212999


ENSG00000105576


ENSMUSG00000031691


O14787


Q99LG2

RefSeq (mRNA)


NM_013433 NM_001136195 NM_001136196


NM_001122843 NM_145390

RefSeq (protein)


NP_001129667 NP_001129668 NP_038461 NP_001129667.1 NP_038461.2


NP_001116315 NP_663365

Location (UCSC)

Chr 19: 12.7 – 12.72 Mb

Chr 19: 85.04 – 85.06 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Transportin-2 is a protein that in humans is encoded by the TNPO2 gene.^[5]^[6]^[7]

Interactions

TNPO2 has been shown to interact with NXF1,^[6] NUP98^[8] and Ran (biology).^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000105576 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031691 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Siomi MC, Eder PS, Kataoka N, Wan L, Liu Q, Dreyfuss G (October 1997). "Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins". J Cell Biol. 138 (6): 1181–92. PMC 2132560 . PMID 9298975. doi:10.1083/jcb.138.6.1181.
1 2 3 Shamsher MK, Ploski J, Radu A (October 2002). "Karyopherin beta 2B participates in mRNA export from the nucleus". Proc Natl Acad Sci U S A. 99 (22): 14195–9. PMC 137860 . PMID 12384575. doi:10.1073/pnas.212518199.
↑ "Entrez Gene: TNPO2 transportin 2 (importin 3, karyopherin beta 2b)".
↑ Fontoura, B M; Blobel G; Yaseen N R (October 2000). "The nucleoporin Nup98 is a site for GDP/GTP exchange on ran and termination of karyopherin beta 2-mediated nuclear import". J. Biol. Chem. UNITED STATES. 275 (40): 31289–96. ISSN 0021-9258. PMID 10875935. doi:10.1074/jbc.M004651200.

Further reading

Gallouzi IE, Steitz JA (2001). "Delineation of mRNA export pathways by the use of cell-permeable peptides.". Science. 294 (5548): 1895–901. PMID 11729309. doi:10.1126/science.1064693.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Blanc V, Kennedy S, Davidson NO (2003). "A novel nuclear localization signal in the auxiliary domain of apobec-1 complementation factor regulates nucleocytoplasmic import and shuttling.". J. Biol. Chem. 278 (42): 41198–204. PMID 12896982. doi:10.1074/jbc.M302951200.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Güttinger S, Mühlhäusser P, Koller-Eichhorn R, et al. (2004). "Transportin2 functions as importin and mediates nuclear import of HuR.". Proc. Natl. Acad. Sci. U.S.A. 101 (9): 2918–23. PMC 365720 . PMID 14981248. doi:10.1073/pnas.0400342101.
Rebane A, Aab A, Steitz JA (2004). "Transportins 1 and 2 are redundant nuclear import factors for hnRNP A1 and HuR.". RNA. 10 (4): 590–9. PMC 1370549 . PMID 15037768. doi:10.1261/rna.5224304.
Lee BJ, Cansizoglu AE, Süel KE, et al. (2006). "Rules for nuclear localization sequence recognition by karyopherin beta 2.". Cell. 126 (3): 543–58. PMC 3442361 . PMID 16901787. doi:10.1016/j.cell.2006.05.049.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. PMC 1847948 . PMID 17353931. doi:10.1038/msb4100134.

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