TNFSF12-TNFSF13

Available structures

Human UniProt search: PDBe RCSB

List of PDB id codes
4HT1

Identifiers

Aliases

TNFSF12-TNFSF13, TWE-PRIL, TNFSF12-TNFSF13, TNFSF12-TNFSF13 readthrough

External IDs

MGI: 3845075 HomoloGene: 123930 GeneCards: TNFSF12-TNFSF13

Gene location (Human)

Chr.	Chromosome 17 (human)^[1]

Band	No data available	Start	7,549,099 bp^[1]
Band	No data available	End	7,561,601 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	No data available	Start	69,682,577 bp^[2]
Band	No data available	End	69,696,098 bp^[2]

Gene ontology
Molecular function	• cytokine activity • protein binding • tumor necrosis factor receptor binding • receptor binding
Cellular component	• integral component of membrane • membrane • plasma membrane • integral component of plasma membrane • extracellular region • perinuclear region of cytoplasm • extracellular space
Biological process	• cell differentiation • positive regulation of endothelial cell proliferation • positive regulation of protein catabolic process • extrinsic apoptotic signaling pathway • tumor necrosis factor-mediated signaling pathway • positive regulation of angiogenesis • multicellular organism development • angiogenesis • immune response • apoptotic signaling pathway • positive regulation of extrinsic apoptotic signaling pathway • endothelial cell migration • signal transduction • apoptotic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


407977


619441

Ensembl


ENSG00000248871


ENSMUSG00000018752

UniProt


O43508


n/a

RefSeq (mRNA)


NM_172089


NM_001034097 NM_001034098 NM_001159503

RefSeq (protein)


NP_003800 NP_742086


n/a

Location (UCSC)

Chr 17: 7.55 – 7.56 Mb

Chr 17: 69.68 – 69.7 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Tumor necrosis factor (ligand) superfamily, member 12-member 13, also known as TNFSF12-TNFSF13, is a human gene.^[5]

This gene belongs to the tumor necrosis factor superfamily (TNFSF). It encodes a hybrid protein composed of the cytoplasmic and transmembrane domains of the family member 12 fused to the C-terminal domain of the family member 13. The hybrid protein is membrane anchored and presents the receptor-binding domain of the family member 13 at the cell surface. It stimulates cycling in T-lymphoma and B-lymphoma cell lines. The mRNA transcript is expressed and translated in primary T cells and monocytes.^[5]

References

Hahne M, Kataoka T, Schröter M, et al. (1998). "APRIL, a New Ligand of the Tumor Necrosis Factor Family, Stimulates Tumor Cell Growth". J. Exp. Med. 188 (6): 1185–90. PMC 2212534 . PMID 9743536. doi:10.1084/jem.188.6.1185.
Kelly K, Manos E, Jensen G, et al. (2000). "APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death". Cancer Res. 60 (4): 1021–7. PMID 10706119.
Wu Y, Bressette D, Carrell JA, et al. (2001). "Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS". J. Biol. Chem. 275 (45): 35478–85. PMID 10956646. doi:10.1074/jbc.M005224200.
Yu G, Boone T, Delaney J, et al. (2001). "APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity". Nat. Immunol. 1 (3): 252–6. PMID 10973284. doi:10.1038/79802.
Gallouzi IE, Brennan CM, Steitz JA (2001). "Protein ligands mediate the CRM1-dependent export of HuR in response to heat shock". RNA. 7 (9): 1348–61. PMC 1370177 . PMID 11565755. doi:10.1017/S1355838201016089. (Retracted. If this is intentional, please replace {{Retracted}} with {{Retracted|intentional=yes}}.)
López-Fraga M, Fernández R, Albar JP, Hahne M (2002). "Biologically active APRIL is secreted following intracellular processing in the Golgi apparatus by furin convertase". EMBO Rep. 2 (10): 945–51. PMC 1084076 . PMID 11571266. doi:10.1093/embo-reports/kve198.
Roschke V, Sosnovtseva S, Ward CD, et al. (2002). "BLyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseases". J. Immunol. 169 (8): 4314–21. PMID 12370363. doi:10.4049/jimmunol.169.8.4314.
Pradet-Balade B, Medema JP, López-Fraga M, et al. (2002). "An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK–APRIL fusion protein". EMBO J. 21 (21): 5711–20. PMC 131062 . PMID 12411489. doi:10.1093/emboj/cdf565.
Hendriks J, Planelles L, de Jong-Odding J, et al. (2005). "Heparan sulfate proteoglycan binding promotes APRIL-induced tumor cell proliferation". Cell Death Differ. 12 (6): 637–48. PMID 15846369. doi:10.1038/sj.cdd.4401647.

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TNFSF12-TNFSF13

References

Further reading