TMX3

TMX3

Identifiers

TMX3, PDIA13, TXNDC10, thioredoxin related transmembrane protein 3

External IDs

MGI: 2442418 HomoloGene: 10381 GeneCards: TMX3

Gene location (Human)

Chr.	Chromosome 18 (human)^[1]

Band	No data available	Start	68,673,688 bp^[1]
Band	No data available	End	68,715,298 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 18 (mouse)^[2]

Band	No data available	Start	90,510,154 bp^[2]
Band	No data available	End	90,543,267 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• protein binding • isomerase activity • thiol oxidase activity • protein disulfide isomerase activity
Cellular component	• integral component of membrane • cell surface • endoplasmic reticulum membrane • endoplasmic reticulum • membrane • platelet alpha granule membrane • plasma membrane
Biological process	• peptidyl-cysteine oxidation • protein folding • response to endoplasmic reticulum stress • cell redox homeostasis • platelet degranulation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


54495


67988


ENSG00000166479


ENSMUSG00000024614


Q96JJ7


Q8BXZ1

RefSeq (mRNA)


NM_019022


NM_198295

RefSeq (protein)

NP_061895 NP_001337441 NP_001337442 NP_001337443 NP_001337444
NP_001337445 NP_001337446


NP_938037

Location (UCSC)

Chr 18: 68.67 – 68.72 Mb

Chr 18: 90.51 – 90.54 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Protein disulfide-isomerase TMX3 is an enzyme that in humans is encoded by the TMX3 gene.^[5]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000166479 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024614 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Haugstetter J, Blicher T, Ellgaard L (Feb 2005). "Identification and characterization of a novel thioredoxin-related transmembrane protein of the endoplasmic reticulum". J Biol Chem. 280 (9): 8371–80. PMID 15623505. doi:10.1074/jbc.M413924200.
↑ "Entrez Gene: TXNDC10 thioredoxin domain containing 10".

Further reading

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMC 310948 . PMID 11076863. doi:10.1101/gr.143000.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. PMC 311072 . PMID 11230166. doi:10.1101/gr.GR1547R.
Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 8 (2): 85–95. PMID 11347906. doi:10.1093/dnares/8.2.85.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. PMC 528930 . PMID 15489336. doi:10.1101/gr.2576704.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. PMC 1347501 . PMID 16381901. doi:10.1093/nar/gkj139.
Haugstetter J, Maurer MA, Blicher T, et al. (2008). "Structure-function analysis of the endoplasmic reticulum oxidoreductase TMX3 reveals interdomain stabilization of the N-terminal redox-active domain.". J. Biol. Chem. 282 (46): 33859–67. PMID 17881353. doi:10.1074/jbc.M706442200.

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