TM4SF5

TM4SF5
Identifiers
Aliases	TM4SF5, transmembrane 4 L six family member 5
External IDs	MGI: 1922854 HomoloGene: 2947 GeneCards: TM4SF5
Gene location (Human) Chr. Chromosome 17 (human)[1] Band No data available Start 4,771,884 bp[1] End 4,783,213 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band No data available Start 70,505,244 bp[2] End 70,511,178 bp[2]
RNA expression pattern More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9032	75604
Ensembl	ENSG00000142484	ENSMUSG00000018919
UniProt	O14894	n/a
RefSeq (mRNA)	NM_003963	NM_029360
RefSeq (protein)	NP_003954	n/a
Location (UCSC)	Chr 17: 4.77 – 4.78 Mb	Chr 17: 70.51 – 70.51 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Transmembrane 4 L6 family member 5 is a protein that in humans is encoded by the TM4SF5 gene.^[5][6]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence and structure to transmembrane 4 superfamily member 1. It may play a role in cell proliferation, and overexpression of this protein may be associated with the uncontrolled growth of tumour cells.^[6]

References

Further reading