TINAGL1

TINAGL1

Identifiers

TINAGL1, ARG1, LCN7, LIECG3, TINAGRP, tubulointerstitial nephritis antigen like 1

External IDs

MGI: 2137617 HomoloGene: 41472 GeneCards: TINAGL1

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	No data available	Start	31,576,485 bp^[1]
Band	No data available	End	31,587,686 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)^[2]

Band	No data available	Start	130,164,454 bp^[2]
Band	No data available	End	130,175,122 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• scavenger receptor activity • polysaccharide binding • cysteine-type endopeptidase activity • laminin binding • extracellular matrix structural constituent • protein binding • cysteine-type peptidase activity
Cellular component	• cytoplasm • extracellular matrix • extracellular region • lysosome • extracellular exosome • extracellular space
Biological process	• endosomal transport • cell adhesion • proteolysis involved in cellular protein catabolic process • receptor-mediated endocytosis • immune response • proteolysis
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


64129


94242


ENSG00000142910


ENSMUSG00000028776


Q9GZM7


Q99JR5

RefSeq (mRNA)


NM_001204414 NM_001204415 NM_022164


NM_001168333 NM_023476

RefSeq (protein)


NP_001191343 NP_001191344 NP_071447


NP_001161805 NP_075965

Location (UCSC)

Chr 1: 31.58 – 31.59 Mb

Chr 1: 130.16 – 130.18 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Tubulointerstitial nephritis antigen-like is a protein that in humans is encoded by the TINAGL1 gene.^[5]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000142910 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028776 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Wex T, Lipyansky A, Bromme NC, Wex H, Guan XQ, Bromme D (Feb 2001). "TIN-ag-RP, a novel catalytically inactive cathepsin B-related protein with EGF domains, is predominantly expressed in vascular smooth muscle cells". Biochemistry. 40 (5): 1350–7. PMID 11170462. doi:10.1021/bi002266o.
↑ "Entrez Gene: TINAGL1 tubulointerstitial nephritis antigen-like 1".

Further reading

Brömme NC, Wex T, Wex H, et al. (2000). "Cloning, characterization, and expression of the human TIN-ag-RP gene encoding a novel putative extracellular matrix protein.". Biochem. Biophys. Res. Commun. 271 (2): 474–80. PMID 10799322. doi:10.1006/bbrc.2000.2639.
Jiang LQ, Wen SJ, Wang HY, Chen LY (2003). "Screening the proteins that interact with calpain in a human heart cDNA library using a yeast two-hybrid system.". Hypertens. Res. 25 (4): 647–52. PMID 12358155. doi:10.1291/hypres.25.647.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. PMC 403697 . PMID 12975309. doi:10.1101/gr.1293003.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. PMC 442148 . PMID 15231748. doi:10.1101/gr.2334104.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. PMC 2286551 . PMID 15340161. doi:10.1110/ps.04682504.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression.". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. PMC 524842 . PMID 15498874. doi:10.1073/pnas.0404089101.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. PMID 16303743. doi:10.1093/dnares/12.2.117.
Umeyama H, Iwadate M, Taguchi YH (2014). "TINAGL1 and B3GALNT1 are potential therapy target genes to suppress metastasis in non-small cell lung cancer.". BMC Genomics. 15 (Suppl 9): S2. PMC 4290609 . PMID 25521548. doi:10.1186/1471-2164-15-S9-S2.
Bosse K, Haneder S, Arlt C, Ihling CH, Seufferlein T, Sinz A (2016). "Mass spectrometry-based secretome analysis of non-small cell lung cancer cell lines.". Proteomics. 16 (21): 2801–2814. PMID 27569058. doi:10.1002/pmic.201600297.

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