THB
THB may refer to:
- Tetrahydrobiopterin, a chemical
- Thai baht, the currency of Thailand (ISO 4217 code: THB)
- THB (comics), and its eponymous character Tri-Hydro Bi-Oxygenate
- The Holy Bible
- The Hydra Bay, a piracy site
- Thomas Hart Benton (painter) (1889–1975), American painter and muralist
- Thomas Hart Benton (senator) (1782–1858), American politician from Missouri and great uncle of the painter
- Three Horses Beer, a beer made in Madagascar
- Too Hard Basket
- Toronto, Hamilton and Buffalo Railway
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